Antifungal activity of microbial chondroitin sulfate against candida albicans

Unver, Tuba; Erenler, Ayse Sebnem; Melekoğlu, Rauf; Akpolat, Nusret; Seçki̇n, Turgay; Azimov, Raul; Ozaslan, Fatma

doi:10.5455/medscience.2019.08.9208

Cited by 2 publications

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“…Consequently, the produced MCS was confirmed by analysis by NMR Spectroscopy (Bruker Advance III HD 600 MHz spectrometer). [31,32,33]…”

Section: Microbial Chondroitin Sulfation Methodsmentioning

confidence: 99%

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Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

Unver,

Erenler,

Bingul

et al. 2023

Chemistry & Biodiversity

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Chondroitin synthesis was performed using the recombinant Escherichia coli (C2987) strain created by transforming the plasmid pETM6‐PACF‐vgb, which carries the genes responsible for chondroitin synthesis, kfoA, kfoC, kfoF, and the Vitreoscilla hemoglobin gene (vgb). Then, Microbial chondroitin sulfate (MCS)'s antioxidant, anticholinesterase, and antibacterial activity were compared with commercial chondroitin sulfate (CCS). The antioxidant studies revealed that the MCS and CCS samples could be potential targets for scavenging radicals and cupric ion reduction. MCS demonstrated better antioxidant properties in the ABTS assay with the IC50 value of 0.66 mg than CCS. MCS showed 2.5‐fold for DPPH and almost 5‐fold for ABTS•+ (with a value of 3.85 mg/mL) better activity than the CCS. However, the compounds were not active for cholinesterase enzyme inhibitions. In the antibacterial assay, the Minimum inhibitory concentration (MIC) values of MCS against S. aureus, E. aerogenes, E. coli, P. aeruginosa, and K. pneumoniae (0.12, 0.18, 0.12, 0.18, and 0.18 g/mL, respectively) were found to be greater than that of CCS (0.42, 0.48, 0.36, 0.36, and 0.36 g/mL, respectively). This study demonstrates that MCS is a potent pharmacological agent due to its physicochemical properties, and its usability as a therapeutic‐preventive agent will shed light on future studies.

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“…Consequently, the produced MCS was confirmed by analysis by NMR Spectroscopy (Bruker Advance III HD 600 MHz spectrometer). [31,32,33]…”

Section: Microbial Chondroitin Sulfation Methodsmentioning

confidence: 99%

“…[31,32] Moreover, our previous study has proven the antifungal activity of MCS. [33] This study aims to discuss the production of MCS by biotechnological methods and its antioxidant, anticholinesterase, and antibacterial effects compared to animal-originated commercial Chondroitin Sulfate (CCS).…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

Unver,

Erenler,

Bingul

et al. 2023

Chemistry & Biodiversity

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Toward sustainable menstrual health management: focus on super absorbent polymers

Mogale,

Schutte-Smith,

Erasmus

et al. 2024

J Mater Sci

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In low- to middle-income communities, the lack of affordability of conventional sanitary products during menstrual cycles can cause psychological and health issues, ultimately affecting their quality of life. It is crucial to develop alternative products that are affordable and accessible to all while also promoting menstrual health and hygiene. Super absorbent polymers (SAPs) are a vital component in current disposable sanitary pads and nappies. However, these SAPs are often non-biodegradable and non-biocompatible. Therefore, the use of eco-friendly materials for the production of SAPs is gaining popularity in the hygiene industry, as it offers a means to reduce the carbon footprint and environmental impact associated with traditional SAPs made from non-renewable petroleum-based materials. SAPs made from polysaccharides often have naturally occurring antibacterial properties, making them appealing for commercial applications in sanitary products such as sanitary pads. In addition, the move toward reusable sanitary pads with antibacterial properties can significantly reduce waste generated by single-use products and prevent the growth of bacteria, improving the safety and hygiene of the product. Furthermore, computational modeling and artificial intelligence are now important tools in SAP synthesis, providing advantages such as predicting polymer properties, rationalizing synthesis pathways, and improving quality control. These tools can reduce synthesis costs by eliminating the need for trial-and-error approaches in polymer synthesis, ultimately promoting more affordable products for end users. Overall, these advancements in polymer synthesis and material design can help to create a more sustainable industry and promote menstrual hygiene and product accessibility to those who need it most.

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Antifungal activity of microbial chondroitin sulfate against candida albicans

Cited by 2 publications

References 0 publications

Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

Comparative Analysis of Antioxidant, Anticholinesterase, and Antibacterial Activity of Microbial Chondroitin Sulfate and Commercial Chondroitin Sulfate

Toward sustainable menstrual health management: focus on super absorbent polymers

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