Antifungal activity of monoterpenes against wood white-rot fungi

Zhang, Zhilin; Yang, Ting; Mi, Na; Wang, Yong; Li, Guoyuan; Wang, Lihua; Xie, Yongjian

doi:10.1016/j.ibiod.2015.10.018

Cited by 70 publications

(59 citation statements)

References 38 publications

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“…Synthesis of carvacrol/thymol derivatives using anhydrides Vol. 41,No. 4 to a GCMS-QP2010SE mass spectrometer using the RTX-5MS capillary column (30 m x 0.25 mm x 0.25 μm) at a flow rate of 1.46 mL min -1 using helium as the carrier gas.…”

Section: General Methodsmentioning

confidence: 99%

“…They are widely reported in research that investigates pharmacological potential, presenting several related therapeutic activities, such as antioxidant, larvicidal, antimicrobial, anti-inflammatory, cytotoxic, among others. [1][2][3][4] In order to develop new drugs, it is of great interest to use bioactive natural products as a raw material in the synthesis of new compounds, seeking to increase their therapeutic capacities, besides reducing side effects and toxicity. Modifications can be made to the molecule in order to introduce groups that confer new properties, such as hydrophobicity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Mesquita¹,

Nascimento²,

Souza³

et al. 2018

Quim. Nova

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In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a, 2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC 50 values of 23.60 ppm, considered a very good result.

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Section: General Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Mesquita¹,

Nascimento²,

Souza³

et al. 2018

Quim. Nova

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“…Porém, esses produtos industriais são tóxicos aos seres humanos, aos organismos não xilófagos e são compostos por metais como cobre, cromo, zinco, arsênio, boro e flúor, além de complexos como creosoto e aminas (ZHANG et al, 2016). Dessa forma, há uma crescente necessidade de inovação tecnológica em produtos antifúngicos eficazes e que não agridam o meio ambiente (GONZÁLEZ-LAREDO et al, 2015;MACHADO et al, 2006).…”

Section: Introductionunclassified

“…Algumas espécies arbóreas possuem natural resistência a diversos organismos deterioradores por produzirem compostos polifenólicos, flavonóides, lignanas, estilbenos e taninos (GAO et al, 2006;LIIMATAINEN et al, 2012;RAMÍREZ et al 2012;SMEDS et al, 2011;ZHANG et al, 2016); ou seja, a presença dessas substân-cias na madeira está relacionada com um aumento na vida útil do material (MAKINO et al, 2011;YAO et al, 2010).…”

Section: Introductionunclassified

Atividade antifúngica do extrato natural da acácia-negra à Pycnoporus sanguineus

Silveira¹,

Santini²,

Kulczynski³

et al. 2017

Sci. For.

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ResumoEntre os organismos xilófagos, os fungos são os maiores responsáveis por grandes prejuízos na produção de madeira. O uso de fungicidas químicos por tempo prolongado tem como implicação o surgimento de linhagens mais resistentes e a toxidez ao ambiente. O objetivo do presente trabalho foi avaliar o efeito fungitóxico do extrativo tanino derivado da Acácia Negra (Acacia mearnsii) sobre o crescimento micelial do fungo Pycnoporus sanguineus, causador da podridão branca. Três metodologias foram elaboradas para trabalhar com o produto (esterilizando, não esterilizando e filtrando) e quatro concentrações (0,5; 1,0; 1,5 e 2,0%) foram individualmente incorporadas ao meio de cultura (BDA), avaliando-se o crescimento radial do micélio avaliados e comparados com a testemunha. O procedimento se repetiu com a metodologia avaliada como sendo a mais adequada, porém aumentando as concentrações (3,0; 4,0 e 5,0%). As concentrações de 4 e 5% mostraram-se as mais eficientes sobre a atividade fúngica, sendo que a segunda demonstrou inibição total em 50% das placas avaliadas, apresentando também o menor índice de crescimento micelial dentre todos os tratamentos testados.Palavras-chave: tanino, decomposição, podridão branca, ensaio fungitóxico. AbstractAmong the xylophagous organisms, fungi are mostly responsible for major losses in wood production. The prolonged use of chemical fungicides implies in the emergence of more resistant lines and toxicity in the environment. The goal of this study was to evaluate the toxic effect of the tannin extractive derived from the black wattle (Acacia mearnsii) on the mycelial growth of the fungus Pycnoporus sanguineus, causing white rot. Three methodologies have been developed to work with the product (sterilizing, nonsterilizing and filtering) and four concentrations (0.5, 1.0, 1.5 and 2.0%) were individually incorporated into the culture medium, evaluating the radial growth of the evaluated mycelium and results were compared with the non-treated specimen. The procedure was repeated with the methodology evaluated as being the most adequate, but increasing concentrations (3.0, 4.0 and 5.0%). The concentrations 4 and 5% were more efficient to fungal activity, and the second showed total inhibition in 50% of the plaques evaluated, also showing the smallest mycelial growth rate among all treatments tested.

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“…Pine is widely utilized in Chinese drinks and herbal medicine and is recommended in Ayurvedic medicine for treating rheumatism, diabetes, obesity, gonorrhea, chronic bronchitis, cancer, and stomach and cardiovascular diseases (Kim and Chung 2000;Singh et al 2011Singh et al , 2015Zeng et al 2011Zeng et al , 2012bZhang et al 2015Zhang et al , 2016. Pine needles is a recognized health food material and is widely used as a flavoring agent in foods and beverages (Kim and Chung 2000;Ratola et al 2010;Zeng et al 2012a;van Drooge et al 2014;Mahajan et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Optimization Protocol for the Microwave-Assisted Extraction of Antioxidant Components from Pinus elliottii Needles Using Response Surface Methodology

et al. 2016

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Response surface methodology (RSM) based on a Box-Behnken rotatable design was used to determine t h e optimum conditions for t h e microwave-assisted extraction of antioxidant compounds from Pinus elliottii needles. Four process variables were evaluated at three levels (29 experimental conditions): ethanol (50, 70, and 90%), solvent:solute ratio (25:1, 20:1, and 15:1), extraction temperature (60, 70, and 80 °C), and ultrasonic power (100, 150, and 200 W). Using RSM, a quadratic polynomial equation was obtained by multiple regression analysis to predict the optimized extraction protocol. The radical scavenging capacity was determined by O2 − , ·OH, and DPPH methods. For the microwaveassisted extraction of antioxidant compounds from Pinus elliottii needles, the optimum process used ethanol at 72%, a solvent:solute ratio of 21:1 mL/g, an extraction temperature of 67 °C, and an ultrasonic power of 200 W. The results indicated good correlation between total polyphenols content and O2 − , ·OH, and DPPH radical scavenging activities.

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Antifungal activity of monoterpenes against wood white-rot fungi

Cited by 70 publications

References 38 publications

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Atividade antifúngica do extrato natural da acácia-negra à Pycnoporus sanguineus

Optimization Protocol for the Microwave-Assisted Extraction of Antioxidant Components from Pinus elliottii Needles Using Response Surface Methodology

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