Antifungal activity of nanostructured polyaniline combined with fluconazole

Yehgambaram, Pavithra; Prasad, R.G.S.V.; Jakka, Venkata Srinivas; Aparna, R.S.; Phani, A. R.

doi:10.1016/j.jopr.2012.11.009

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…[8] The study of Yehgambaram et al proved that FLU loaded polyaniline (PANI) has high antifungal properties by testing it on C. albicans, C. tropicalis, and C. krusei strains. [9] Sharma et al have shown that the pharmaceutical carrier system in which polyvinyl alcohol (PVA) nanofibrous patch and FLU are used together for the treatment of vaginal candidiasis, has superior antifungal activity potential compared to drug-free systems. [10] Vancomycin (VAN) is a glycopeptide antibiotic that inhibits the synthesis of the cell wall in Gram-positive microorganisms.…”

Section: Introductionmentioning

confidence: 99%

A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug‐Loaded Nanofibrous Patches

Cesur

Ilhan

Pilavci

et al. 2023

Macro Materials & Eng

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Corneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual‐drug loaded dual‐layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug‐loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug‐loaded layers in one patch. According to drug release results, the FLU and VAN‐loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4'‐6diamidynofenyloindol (DAPI) staining, and 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.

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Section: Introductionmentioning

confidence: 99%