Antifungal Activity of Narceine Methyl Ester and Narceine Isolated fromCorydalis longipesAgainst Some Phytopathogenic Fungi

Abstract

Narceine methyl ester and narceine are potent alkaloids which were isolated from Corydalis longipes were found effective in vitro at very low concentration, i.e., 100~500 ppm against spore germination of some test plant pathogenic fungi (Alternaria solani, A. tagetica, Cercospora abelmoschi, Curvularia maculans, Erysiphe cichoracearum, E. pisi, Fusarium udum, Helminthosporium oryzae, H. penniseti, Ustilago cynodontis). Among the test, phytopathogens the spores of F. udum, C. maculans and H. penniseti were highly sensitive at 200 ppm. However, spores of E. pisi, A. solani and A. tagetica were less sensitive at low concentration followed by other test fungi. Most of the fungi showed zero or nearly zero percent spore germination at 400 and 500 ppm.

Circumambulatory Movement of Negative Charge (“Ring Walk”) during Gas-Phase Dissociation of 2,3,4-Trimethoxybenzoate Anion

“…Understanding the fragmentation pathways of this group of compounds is important because benzoic acid derivatives with multiple methoxy groups are widely encountered as secondary metabolites. Some examples are narceine from fungi ( 1 ), sekikaic acid from lichens ( 2 ), and the antibiotic Thielavin B from the marine fungus Thielavia terricola ( 3 ) . Identification of these compounds is not usually straightforward because their isolation in pure form is rather difficult.…”

Decoding the metabolomic responses of Caragana tibetica to livestock grazing in fragile ecosystems

“…Narceine may play a role in the selfdefense mechanism of C. tibetica, reducing plant consumption or damage. Research by Chowdhury et al indicates that narceine, a potent alkaloid isolated from Corydalis longipes, effectively inhibits spore germination of certain plant-pathogenic fungi at low concentrations (Chowdhury et al, 2005). These results suggest that core metabolites validate the impact of grazing intensity changes on C. tibetica, while the RFC model built with these metabolites accurately predicts grazing intensity.…”

“…Simultaneously, core metabolites from the RFC model include narceine. Narceine is an alkaloid, and alkaloids, as a class of metabolites, often possess toxicity, serving as defenses against natural enemies of plants, such as insects and herbivores (Chowdhury et al, 2005). Narceine may play a role in the selfdefense mechanism of C. tibetica, reducing plant consumption or damage.…”

Mass Spectrometry-Based Technology and Workflows for Studying the Chemistry of Fungal Endophyte Derived Bioactive Compounds

“…Out of 12 fractions of S. rostrata , the METLIN database provides a comprehensive list of 17 probable compounds (deacetylisoipecoside, deacetylipecoside, isopropylidene, azastreptonigrin, doxorubicinol, epirubicinol, 3-( N -maleimidopropionyl)-biocytin, terbinafine, glucuronide, eremosulphoxinolide A, eremopetasitenin B2, etodolac glucuronide, ritodrine glucuronide, ritodrine glucuronide 2, dubiusine, narceine, and phenethyl rutinoside) present in the fourth fraction of S. rostrata . Narceine has been recognized as an antifungal agent in previous reports . Doxorubicinol (DOXol) has been reported to show cardiotoxicity .…”

“…has been done by dereplication based on , dubiusine, narceine, and phenethyl rutinoside) present in the fourth fraction of S. rostrata. 66 Narceine has been recognized as an antifungal agent in previous reports 67. Doxorubicinol (DOXol) has been reported to show cardiotoxicity 68.…”