Antifungal Activity of Pericopsis (Afrormosia) laxiflora (Benth.) Bark on Ringworm Germs

Abou, Ouattara; Eric-Kevin, Bolou Gbouhoury; Eugène, Koffi Allali; Hyacinthe, Yasseu; Karamoko, Ouattara; Coulibaly, Adama

doi:10.9734/mrji/2020/v30i430207

Cited by 4 publications

(5 citation statements)

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“…[27] Activities of hydroethanolic extract of the bark of Afromosia laxiflora have also been evaluated showing it as a bioactive dermatophyte agent. [28] Overall, results from this study agree strongly with those from reported literature and thereby support the antifungal potentials of active extracts recorded with significant MICs such as F. albida, S. setigera, A. senegalensis, U. picta C. collinum, and A. laxiflora plant species. The antifungal information (data) presented herein can be exploited for their further evaluations as antimicrobial drug leads of nature.…”

Section: Minimum Inhibitory Concentration (Mic)supporting

confidence: 90%

Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

Nefai¹,

Emanuel²,

Rabiu³

et al. 2022

Pharmacogn. Res.

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Background: An earlier ethnobotanical study afforded fifteen surveyed plants, which are used as antifungal and wound healing remedies. This informed their antifungal screening to validate folklore claims. Materials and Methods: Identified, procured, and authenticated medicinal plants were each, defatted in hexane and extracted with methanol before partitioning with n-butanol to obtain an n-butanol extract with solubilized antifungal compounds in the organic phase. The resulting concentrated n-butanol extracts were then screened by subjecting each plant extract to in vitro antifungal assay for the determination of the minimum inhibitory concentration (MIC) of the extract on Aspergillus niger in a 96-well flat bottom polystyrene microtiter plate using the broth microdilution method as outlined in the 2021 Clinical and Laboratory Standard Institute guideline. Results: The antifungal screening of the plants presented active plant extracts with variable antifungal properties of MIC values ranging from 3.9 to 250 (mg/ml). Only the extract of Balanites aegyptica showed no activity at all concentrations tested. The lowest extreme was recorded for Ficus Platyphylla, which gave a slight activity at the highest MIC of 125mg/ml, while the highest activity was recorded for Faidherbia albida at the lowest test concentration with a MIC of 3.90625 mg/ml. The other thirteen extracts exhibited antifungal activity in varying degree with the following MICs: Stecullia setigera (7.8125 mg/ml), Annona senegalensis (7.8125 mg/ml), Uraria picta (7.8125 mg/ml) Combretum collinum (15.65 mg/ml), Afromosia lexiflora (15.65 mg/ml), Waltheria indica (15.65 mg/ml), Guiera senegalensis (15.65 mg/ml), Carica papaya (31.25 mg/ml), Rogeria adenophylla (31.25 mg/ml), Pennisetum hordeoides (31.25 mg/ml), Acacia nilotica (31.25 mg/ml) and Sida ovata (62.5 mg/ml). Conclusion: The in vitro antifungal potential of these surveyed plants supports their traditional use, hence, information (data) furnished by this study can be exploited for their further evaluations as antimicrobial drug leads of nature.

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Section: Minimum Inhibitory Concentration (Mic)supporting

confidence: 90%

Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

Nefai¹,

Emanuel²,

Rabiu³

et al. 2022

Pharmacogn. Res.

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“…They were then cut into small fragments and dried in an oven at 50°C for 5 days. These dried barks were then reduced to very fine powders which will be used for the preparation of hydroethanol extracts according to the method described by Ouattara et al 8 with some modifications. Indeed, 100 g of plant powder were shaken vigorously in 1L of 70% ethanol using an electric mixer.…”

Section: Preparation Of Hydroalcoholic Plant Extractsmentioning

confidence: 99%

Evaluation of the antifungal powers of five plant species of the genus Terminalia on strains responsible for candidiasis

BOLOU

YAO²,

AGRE³

et al. 2022

J. Drug Delivery Ther.

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Background: Candidiasis is a fungal disease caused by Candida albicans, a yeast that preferentially affects mucous membranes. These diseases are more and more recurrent because of the generalized decline in immunity and the appearance of resistance to classical antifungal drugs. Therefore, fighting against therapeutic failures becomes necessary. The objective of this study is to contribute to the fight against candidiasis through the research of new antifungal molecules. To do so, the hydroalcoholic extracts of Terminalia catappa, Terminalia glaucescens, Terminalia ivorensis, Terminalia mantaly and Terminalia superba, five plant species used in traditional medicine against dermatoses, were tested on the in vitro growth of resistant strains of Candida albicans. In addition, the polyphenol composition of these plants was carried out in order to evaluate their protective powers. Methods: The antifungal tests were performed by the solid-state dilution method. While the determination of polyphenols was performed by the photometric method. Results: The results showed an inhibition of the growth of germs by four plants except Terminalia catappa. The minimum inhibitory concentrations (MIC) obtained are as follows: MIC (T. ivorensis) =0.25 mg/mL; MIC (T. glaucescens) =0.50 mg/mL; MIC (T. superba) = 4 mg/ML; MIC (T. mantaly) = 2 mg/mL. Conclusion: This study indicates that T. ivorensis is the most active and has the highest content of phenolic compounds. This plant could be a source of effective molecules in the treatment of candidiasis. Keywords: Candida albicans, candidiasis, Terminalia, antifungal, polyphenol,

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“…In La Côte d'Ivoire, P. laxiflora is used traditionally to treat many health conditions including headache, stomach ulcers, stomach aches, upset stomach, gastritis, enteritis, heart pain, abdominal pain [10] while in Guinea, it is used against shigellosis and colibacillosis [11]. This plant is used for the treatment of malaria, jaundice and ulcer [12].…”

Section: Medicinal Uses Of Pericopsis Laxiflora Stem Barkmentioning

confidence: 99%

“…Ethyl acetate, methanol and aqueous crude extracts of P. laxiflora were all reported to contain tannins, flavonoids, steroids and terpenoids, cardiac glycosides, saponins, phenolic compounds, alkaloid and reducing compounds in different proportions [10].…”

Section: Chemical Compostion Of Pericopsis Laxifloramentioning

confidence: 99%

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Ethnobotany, Phytochemistry and Pharmacology of Pericopsis laxiflora (Baker) Meeuwen (Leguminosae) – A Review

Sarfo-Antwi

Larbie

Emikpe

et al. 2021

IJBcRR

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Pericopsis laxiflora (Family Leguminosae) is a medicinal plant that is ubiquitous especially in the tropical and savannah regions. There are many reports on folkloric and traditional medicinal uses that include haemorrhoids, rheumatism, abdominal pain treatment, diarrhoea, and dysentery, fever, skin diseases and jaundice. Peer-reviewed articles were gathered by consulting the databases of Scopus, Medline, Web of Science, PubMed, Science Direct and Google Scholar. Phytochemical investigations have revealed many bioactive compounds such as β-carboline derivative and tryptamine derivative. The plant has been examined on the basis of the in vitro, in vivo or clinical evaluations and shown to possess major pharmacological activities. These include anti-trypanosomal, antimicrobial, antibacterial, antioxidant and anti-malarial activities. In the present review, an attempt has been made to congregate the traditional, phytochemical and pharmacological studies performed on Pericopsis laxiflora. Comprehensive safety and efficacy studies must be conducted on the plant. Generally, there are knowledge gaps that must be filled. Thus this review is intended for practitioners and researchers in the fields of ethnopharmacology, natural product chemistry and drug discovery related research.

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Antifungal Activity of Pericopsis (Afrormosia) laxiflora (Benth.) Bark on Ringworm Germs

Cited by 4 publications

References 0 publications

Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

Evaluation of the antifungal powers of five plant species of the genus Terminalia on strains responsible for candidiasis

Ethnobotany, Phytochemistry and Pharmacology of Pericopsis laxiflora (Baker) Meeuwen (Leguminosae) – A Review

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