Antifungal activity of plant extracts against dermatophytes

Ali‐Shtayeh, Mohammed S.; Ghdeib, Suheil I. Abu

doi:10.1046/j.1439-0507.1999.00499.x

Cited by 255 publications

(125 citation statements)

References 41 publications

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“…The similar to that from the work of Ali-Shtayeh and Abu-Ghdeib (1999), who reported that aqueous extracts of 22 plants recorded wide variations in their MIC values against Microsporum canis, Trichophyton mentagrophytes and Trichophyton violaceum. This could be attributed to the variations in the phytochemical properties of the plants and differences among the fungal species.…”

Section: Resultssupporting

confidence: 89%

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

Rosdi¹,

Daud²,

Zulkifli³

et al. 2015

J App Pharm Sci

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A series 305 extracts from 61 traditional medicinal plants (belonging to 33 different families) used in treating skin diseases in Hyderabad Karnataka region were subjected to antidermatophytic screening against Trichophyton rubrum (MTCC 1344). Pet ether, chloroform, ethyl acetate, methanol and aqueous extracts of each plant were tested for their antifungal activity using agar well diffusion method at sample concentration of 5 & 2.5 mg/ml. The results indicated that out of 61 plants, 18 exhibited very effective antidermatophytic activity in methanolic extracts, effective activity observed in 13 plants in different extracts, whereas 26 plants showed moderate activity, 04 plants showed weak activity. The minimum inhibitory concentrations of 18 very effective plants were determined. On the basis of the results obtained, the crude extracts of Allium sativam Linn., Annona reticulata L., Annona squamosa L., Argemone mexicana L., Butea monosperma, Ceasalpinia bonducella, Citrus medica L., Corchorus oleterius L., Emblica officinalis, Euphorbia tirucalli L., Ficus racemosa L., Gymnosporia montana, Lawsonia inermis L., Solanum nigrum L., Sterculia foetida L., Tribulus terrestris L., Vitex negundo L., and Zingiber officinale exhibited significant antidermatophytic activity (T. rubrum) and properties that support folkloric use in the treatment of skin diseases as broad-spectrum antimycotic agents. This probably explains the use of these plants by the indigenous people against dermatological infections.

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Section: Resultssupporting

confidence: 89%

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

Rosdi¹,

Daud²,

Zulkifli³

et al. 2015

J App Pharm Sci

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“…Namely, the methanol extracts were most active in comparison with acetone and ethyl acetate extracts. The greater effectiveness of the methanol extracts resulted from the fact that methanol is a very useful solvent capable of extracting a wide range of compounds [26]. Weak antimicrobial activity was observed in the extracts of T. botrys, which showed a low total phenolic content.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

et al. 2012

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In vitro antimicrobial activity of 21 crude extracts obtained from seven taxa of the genus Teucrium (T. chamaedrys, T. montanum, T. arduini, T. polium, T. scordium subsp. scordium, T. scordium subsp. scordioides and T. botrys) was tested against bacterial and fungal species. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using a microdilution analysis method. Total phenolic content and flavonoid concentrations were measured spectrophotometrically. Total phenols were determined using Folin-Ciocalteu reagent and their amounts ranged from 28.49 up to 159.84 mg CA/g of extract (chlorogenic acid equivalent). The amounts of flavonoids ranged from 38.17 up to 190.45 mg RU/g of extract (rutin equivalent).The plant extracts showed greater potential of antibacterial than antifungal activity. A relationship was found between total phenolics and biological activity. The highest level of total phenols was measured in the methanol extracts, which demonstrated higher antimicrobial activity than acetone and ethyl acetate extracts. Staphylococcus aureus ATCC 25923 appeared to be the most sensitive organism. Our results indicate that Teucrium spp extracts are rich sources of phenolic compounds and are promising candidates for further development as natural antimicrobial agents.

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“…Plant extracts and their essential oils are one of several non-synthetic chemical control options that have recently received attention for controlling plant diseases (Soylu et al 2005;Abad et al 2007). The methanolic extract of fenugreek was potent in inhibiting dermatophytes and Candida albicans (Shtayeh and Abu Ghdeib 1999;Olli and Kirti 2006). Extracts of harmal seeds and roots were found to contain a mixture of active alkaloids, and among these harmaline was the most active antifungal agent (Telezhenetskaya and Dyakonov 2004).…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Activity of Selected Plant Crude Extracts and Fractions Against Penicillium Italicum

Kanan¹,

Al-Najar²

2009

Journal of Plant Protection Research

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Abstract:The objective of this study is to evaluate (in vitro and in vivo) seven plant extracts and their liquid fractions against four Penicillium italicum isolates. The in vitro study revealed that a concentration 520 µg/ml of crude extract of sticky fleabane leaves or cinnamon bark generated maximum percentage inhibition of 54% and 43%, respectively, against tested fungal isolates. A concentration of 130 µg /ml from each extract (except harmal and garlic where, 390 µg/ml were required) caused complete inhibition of fungal growth of isolates Pi.1 and Pi.3 infecting orange fruit. A concentration of 130 µg/ml of nightshade fruit, fenugreek or sticky fleabane extract inhibited completely the growth of isolates Pi.3 and Pi.5 infecting lemon fruits, whereas a concentration of 390 µg/ml was required to inhibit the growth of isolate Pi.1. Methanolic fractions of cinnamon, garlic or sticky fleabane completely inhibited the growth of fungal isolates. The IC 50 values for these fractions were found to be in the range of: 11.2-24; 30.25-31.50; 25.0-36.0 µg/ml, respectively.A concentration 20 µg/ml of cinnamon hexane fraction inhibited the growth of the fungal isolates, with IC 50 values of 13, 13.75, 14 and 13 µg/ml, respectively, obtained against isolates Pi.1, Pi.3, Pi.5 and Pi.6. The nightshade hexane fraction completely inhibited the growth of isolates Pi.1 and Pi.3 with IC 50 values of 80 and 37.5 µg/ml, respectively. Cinnamon aqueous fraction completely inhibited the growth of isolates Pi.1 and Pi.5 (IC 50 were 61.25 and 58.5 µg/ml, respectively).

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Antifungal activity of plant extracts against dermatophytes

Cited by 255 publications

References 41 publications

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

In Vitro and In Vivo Activity of Selected Plant Crude Extracts and Fractions Against Penicillium Italicum

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