Antifungal activity of scopoletin and its differential accumulation in Ulmus pumila and Ulmus campestris cell suspension cultures infected with Ophiostoma ulmi spores

Growth at elevated CO2 concentrations leads to modified profiles of secondary metabolites in tobacco cv. SamsunNN and to increased resistance against infection with potato virus Y

“…Plants of these transgenic lines showed increased resistance upon inoculation with PVY (Matros & Mock 2004) or TMV (Baumert et al 2001). Several lines of evidence indicate a significant role for scopoletin in defence in a number of plantpathogen interactions (Tal & Robeson 1986;El Modafar et al 1993;Valle et al 1997). A Nicotiana hybrid with increased disease resistance showed the accumulation of both scopolin and its aglycone, and spraying of tobacco prior to TMV inoculation demonstrated that scopoletin, but not scopolin was effective in the reduction of lesion formation (Ahl Goy et al 1993).…”

Ectopic Expression of a UDP-Glucose:phenylpropanoid Glucosyltransferase Leads to Increased Resistance of Transgenic Tobacco Plants Against Infection with Potato Virus Y

“…Several lines of evidence indicate a significant role for scopoletin in defence in a number of plantpathogen interactions. Besides its antimicrobial activity in vitro (Jurd et al 1971), a rapid and intense synthesis of scopoletin was observed for interactions with avirulent pathogens, and a slower and weaker formation was found in interactions with virulent pathogens (El Modafar et al 1993, Valle et al 1997, Tal and Robeson 1986. A Nicotiana hybrid with increased disease resistance showed accumulation of both scopolin and its aglycone.…”

“…The inhibitory effect of several flavanoids including quercetin on virus propagation has been shown for tomato ringspot virus (Malhorta et al 1996) and potato virus X (French and Towers 1992). Correlative evidence for the significance of the coumarins scopolin and scopoletin in disease resistance was given by a number of studies that described the rapid accumulation of scopoletin in several plant-pathogen interactions (Dorey et al 1997, Olson and Roseland 1991, El Modafar et al 1993, Valle et al 1997, Churngchow and Rattarasarn 2001. For tobacco plants reacting hypersensitively the accumulation of scopoletin in a narrow ring of cells around the site of infection was described subsequently to the inoculation with Phytophthora megasperma (Dorey et al 1997) and following infection with TMV (Costet et al 2002).…”

Accumulation of coumarins in Arabidopsis thaliana

“…Their exact roles in plants are unclear. However, they are thought to play some role in plant defense due to the induction of their biosynthesis following various stress events (Garcia et al, 1995;Baillieul et al, 2003;Shimizu et al, 2005) as well as their antimicrobial and antioxidative activities (Valle et al, 1997;Chong et al, 2002;Gachon et al, 2004;Carpinella et al, 2005). So far, comparatively little information is available regarding the biosynthesis of coumarins in plants.…”