Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice

Antimicrobial activity of β-lapachone encapsulated into liposomes against meticillin-resistant Staphylococcus aureus and Cryptococcus neoformans clinical strains

“…In fact, previous in vivo studies performed with Swiss mice treated daily with b-lap (10 mg/kg intravenously) for 7 days and 14 days revealed that blap can be used in the treatment of mice with disseminated cryptococcosis [8]. b-Lap was able to reduce the C. neoformans population 10,000 times in vital organs such as the lungs and brain, although drug toxic effects, such as motor imbalance, abdominal contractions and necrotic lesions in the tail, were observed, as well as death in 33% of the animals.…”

“…b-Lap has attracted increasing attention due to its antibacterial [7], antifungal [8], antischistosomal [9] and antitumour properties [10]. Although b-lap presents pharmacological activity, its low water solubility (0.16 mM) [11] may limit its therapeutic use.…”

Quinones Derived from Plant Secondary Metabolites as Anti-cancer Agents

“…β-LAPACHONE β-Lapachone is a natural naphthoquinone derived from Tabebuia avellanedae (Bignoniaceae) [52]. This molecule exhibits a wide spectrum of pharmacological activities, including anti-fungal, anti-bacterial anti-trypanocidal, and anti-cancer activities [53][54][55]. β-lapachone, a potent anti-cancer agent, can selectively induce cell death in several human cancer cells without killing non-transformed cells [27].…”

Quantitative Analysis of Secondary Metabolites in Aqueous Extract of Clerodendrum Serratum

“…10 Alkaloids are another important class of secondary metabolites having minimum one nitrogen atom either within the heterocyclic ring or outside the ring. Alkaloids are having wide range of physiological effects and pharmacological effects, including antibiotic, 11 antifungal, anti bacterial, anticancer, [12][13][14] narcotics, poisons, stimulants, 15 antimicrobial, anti-HIV and antiparasitic activities etc. 16 The other important metabolites present in plants are terpenoids, glycosides, lignin, coumarins, anthraquinones which also shows versatile therapeutic activity.…”