Antifungal and antibacterial activities of different extracts of<i>Harungana madagascariensis</i>stem bark

Iwalewa, E. O.; Сулейман, М. М.; Mdee, L. K.; Eloff, Jacobus Nicolaas

doi:10.1080/13880200903029316

Cited by 24 publications

(2 citation statements)

References 29 publications

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“…A decoction of the stem bark is used in the management of diabetes [15][16][17]. The bark is also used in the treatment of hepatitis, malaria, river blindness, asthma, dysmenorrhea, ulcer, toothache, nephrosis and gastrointestinal complications [18,19]. In Cameroon, the leaves and seed oil of H. madagascariensis are used to treat typhoid fever and malaria [20].…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis, Antiglycation, Antioxidant and Anti-lipid Peroxidation Activities of Harungana madagascariensis Methanolic Stem Bark Extract

Adetayo,

Modupe,

Sunday

et al. 2023

Trends Sci

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Plants’ natural products make excellent lead for the development of new drugs used for prevention, management and treatment of communicable and non-communicable diseases. The specific aim of the study was to investigate the antioxidant and antiglycation activities of Harungana madagascariensis methanolic stem bark extract. The active compounds present in the plant were extracted using methanol by maceration and resulting extract was subjected to phytochemical screening, antioxidant and antiglycation analysis. The extract was fractioned on silica gel to isolate the antioxidant compounds domiciled in the extract and fractions were identified by bioautography. The H. madagascariensis methanolic stem bark extract showed the presence of tannins, alkaloids, saponins, steroids and flavonoids. From the antioxidant assays, the extract scavenged 2,2-diphenyl-1-picryhydrazyl (DPPH) and nitric oxide radicals, inhibited lipid peroxidation in a dose dependent manner showing IC50 higher than ascorbic acid while it inhibited albumin glycation with IC50 lower than ascorbic acid. From the 12 fractions obtained only 7 fractions showed antioxidant activity and quercetin, flavone, 6-hydroxyflavone, ferulic and o-coumaric acid were inferred. From the GC-MS analysis, fatty acids and their esters, terpenoids and steroids were identified such as Hexadecanoic acid ethyl ester (6.53 %), 9,12,15-Octadecatrienoic acid (5.92 %), 9,12,15-Octadecatrienoic acid methyl ester (0.95 %), vitamin E (1.22 %), phytol (3.87 %), squalene (1.66 %) and Pregn-5-en-3-ol, 21-bromo-20-methyl-(3.beta.)- (1.94 %). In conclusion, H. madagascariensis methanolic stem bark extract possessed antioxidant and antiglycation activities, thus, can be used for new drug development to reduce or combat oxidative stress related diseases in humans. HIGHLIGHTS The methanolic stem bark extract of Harungana madagascariensis exhibited strong antiglycation and antioxidant activities Antioxidant compounds including flavonoids and phenolic acids (quercitin, flavone, 6-hydroxyflavone, ferulic and o-coumaric acid), terpenoids (vitamin E, phytol and squalene) fatty acids and their esters were found in the extract The stem bark extract of Harungana madagascariensis could be used as a source of antiglycation and antioxidant activity for new drug development in preventing oxidative stress related diseases and diabetic complications GRAPHICAL ABSTRACT

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Section: Introductionmentioning

confidence: 99%

GC-MS Analysis, Antiglycation, Antioxidant and Anti-lipid Peroxidation Activities of Harungana madagascariensis Methanolic Stem Bark Extract

Adetayo,

Modupe,

Sunday

et al. 2023

Trends Sci

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“…These bioactive components provide unlimited opportunity for new drugs discovery because of the readily available medicinal diversity (Cos et al, 2006). The antibacterial activity of plants have been demonstrated through many approaches which include crude extract preparation using variety of solvents (Iwalewa et al, 2009) purification of active compounds from the extracts (Voukeng et al, 2017;Seukep et al, 2016;Djeussi et al, 2015;Tankeo et al, 2015) successive extraction with solvents with increasing polarity (Njateng et al, 2016) and distillation. The most common approach is the solvent extraction however recent studies have established high activity with fractionation of crude extracts (Etame et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Comparative antibacterial efficacies of the extracts of <i>Enantia chlorantha</i> (Awopa) on selected clinical isolates

Kamoldeen,

Toyosi,

Yetunde

et al. 2023

SWJ

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Researchers and health scientists are challenged by the phenomenon of antimicrobial resistance which has necessitated the need for the discovery of novel antimicrobial agents. This study evaluated the antimicrobial efficacy of the bark of Enantia chlorantha (Awopa) based on extractions using selected polar and non-polar solvents (Aqueous, Dichloromethane, Petroleum ether, and N-hexane). Antimicrobial activities were investigated against six clinical isolates (Candida albicans, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa) via the agar well diffusion assay. Minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC) were also determined by the macro broth dilution method. The phytochemical components of the extracts were analyzed qualitatively and quantitatively. The dichloromethane extract of E. chlorantha expressed the highest antimicrobial activity against all the test organisms with K. pneumonia being the most susceptible with (21.50 mm zone of inhibition) at a concentration of 50mg/mL; while C. albicans was the least susceptible organism with 3.00 mm zone of inhibition at concentration of 500mg/mL. On the other hand, extract from the petroleum ether expressed no antimicrobial activities, based on the absence of the zones of inhibition around the cultures of the respective organisms. Mainly the Dichloromethane and aqueous extracts of E. chlorantha expressed varying organism-dependent MIC on the test isolates. While the lowest MIC of dichloromethane extract was expressed on S. aureus at 6.25mg/mL; the highest MIC (50mg/mL) was exerted on C. albicans. Phytochemical screening of the extracts revealed the presence of glycosides, oxalates, steroids, alkaloids, tannins, flavonoids, phenol, triterpenes, saponin and phytate; while terpenoid was not found in all the plant’s extracts. Findings in this study suggest that the bioactive ingredients of E. chlorantha barks could be best extracted by polar solvents which are evident in the superior antimicrobial activities of dichloromethane and aqueous extracts. The non-polar solvents such as n-hexane and petroleum ether are poor extractant, thus necessitating the need to carefully select suitable solvent for the extraction of any plant’s bioactive compounds.

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Malagasy Dye Plant Species: A Promising Source of Novel Natural Colorants with Potential Applications – A Review

Andriamanantena

Danthu

Cardon

et al. 2019

Chemistry & Biodiversity

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Due to the potentially harmful effects of some synthetic dyes, there is an increasing demand for natural colorants. Recent literature has emphasized the necessity of investigating new sources of dyes. This review discusses the biological sources of dyes derived from the rich plant diversity of Madagascar. As one of the first contributions on the use of these dyestuffs for dyeing textiles, it provides an overview of 128 dye plant species with other potential applications for coloring materials in industry. A detailed description of the botanical and chemical properties of these dyestuffs is given. We believe that the Madagascar plant diversity may be a promising source of novel colorants not yet investigated. We considered it worthwhile to carry out a thorough scientific study of a set of Malagasy plants carefully selected for their coloring properties together with their potential use and valorization in specialized industries where use of natural colorants would be a particular interest.

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Antifungal and antibacterial activities of different extracts ofHarungana madagascariensisstem bark

Cited by 24 publications

References 29 publications

GC-MS Analysis, Antiglycation, Antioxidant and Anti-lipid Peroxidation Activities of Harungana madagascariensis Methanolic Stem Bark Extract

GC-MS Analysis, Antiglycation, Antioxidant and Anti-lipid Peroxidation Activities of Harungana madagascariensis Methanolic Stem Bark Extract

Comparative antibacterial efficacies of the extracts of <i>Enantia chlorantha</i> (Awopa) on selected clinical isolates

Malagasy Dye Plant Species: A Promising Source of Novel Natural Colorants with Potential Applications – A Review

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