Antifungal and antibacterial activity of extracts produced from Diaporthe schini

Reis, Caroline Medeiros dos; Rosa, Bárbara Vargas da; Rosa, Gisele Padro da; Carmo, Gabriele do; Morandini, Liziane Maria Barassuol; Ugalde, Gustavo A.; Kuhn, Kátia Regina; Morel, Ademir F.; Jahn, Sérgío Luiz; Kuhn, Raquel C.

doi:10.1016/j.jbiotec.2019.01.022

Cited by 53 publications

(8 citation statements)

References 30 publications

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“…In this study, about 81 compounds were identified by GC-MS for strain Nocardiopsis alba (XIEG57); the major peaks in ( Figure 5 D) showed antibacterial activity such as Dibutyl phthalate [ 100 ], 1-Docosene, and 1-nonadecene [ 108 ], 1-hexadecene [ 110 ], and antifungal activity against Pyricularia oryzae such as Pyrrolo [1,2-a] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, and Nonacos-1-ene [ 109 ], and 13-Docosenamide, (Z)- [ 110 ]. Overall, our results supported the development of natural products that may minimize the need for the application of chemical fertilizer and fungicides, which would be an environmentally friendly approach and preserve biological resources in a sustainable agricultural system.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Plant-Microbe Interactions between Endophytic Actinobacteria and Their Role in Plant Growth Promotion and Biological Control of Cotton under Salt Stress

Mohamad

Liu

et al. 2022

Microorganisms

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Bacterial endophytes are well-acknowledged inoculants to promote plant growth and enhance their resistance toward various pathogens and environmental stresses. In the present study, 71 endophytic strains associated with the medicinal plant Thymus roseus were screened for their plant growth promotion (PGP), and the applicability of potent strains as bioinoculant has been evaluated. Regarding PGP traits, the percentage of strains were positive for the siderophore production (84%), auxin synthesis (69%), diazotrophs (76%), phosphate solubilization (79%), and production of lytic enzymes (i.e., cellulase (64%), lipase (62%), protease (61%), chitinase (34%), and displayed antagonistic activity against Verticillium dahliae (74%) in vitro. The inoculation of strain XIEG05 and XIEG12 enhanced plant tolerance to salt stress significantly (p < 0.05) through the promotion of shoot, root development, and reduced the activities of antioxidant enzymes (SOD, POD, and CAT), compared with uninoculated controls in vivo. Furthermore, inoculation of strain XIEG57 was capable of reducing cotton disease incidence (DI) symptoms caused by V. dahliae at all tested salt concentrations. The GC-MS analysis showed that many compounds are known to have antimicrobial and antifungal activity. Our findings provide valuable information for applying strains XIEG05 and XIEG12 as bioinoculant fertilizers and biological control agent of cotton under saline soil conditions.

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Section: Discussionmentioning

confidence: 99%

Synergistic Plant-Microbe Interactions between Endophytic Actinobacteria and Their Role in Plant Growth Promotion and Biological Control of Cotton under Salt Stress

Mohamad

Liu

et al. 2022

Microorganisms

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“…The other fatty acids are most likely the constituents of the fungal structures, such as the cell membrane. Moreover, it has been hexadecenoic acid has biological activity reported for fungi and bacterial [21]. In F4, we identi ed ketamine and palmitic and linoleic acids, as these fatty acids have nematicidal activity that has already been described in the literature [19,20], and this can explain the fact that subfraction 4 had the lowest ED 50 compared to subfraction 5 and commercial ketamine; thus, the substances could be acting in synergy.…”

Section: Discussionmentioning

confidence: 72%

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new role

Ferreira

Machado

Furtado

et al. 2020

Preprint

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Background: Infection by nematodes is a problem for human health, livestock, and agriculture, as it causes deficits in host health, increases production costs, and incurs less food supply. The control of these parasites is usually done using anthelmintics, which, in most cases, have not been fully effective. Therefore, the search for new molecules with anthelmintic potential is necessary. Methods: In the present study, we isolated and characterized molecules from the nematophagous fungus Pochonia chlamydosporia and tested these compounds on three nematodes: Caenorhabditis elegans, Ancylostoma ceylanicum, and Ascaris suum. Results: The ethyl acetate extract showed nematicidal activity on the nematode model C. elegans. We identified the major substance present in two subfractions of this extract as ketamine. Then, we tested this compound on C. elegans and the parasites A. ceylanicum and A. suum using hamsters and mice as hosts, respectively. We did not find a difference between the animal groups when considering the number of worms recovered from the intestines of animals treated with ketamine and albendazole (P ˂ 0.05). The parasite burden of larvae recovered from the lungs of mice treated with ketamine was similar to those treated with ivermectin. Conclusion: These results presented here demonstrate the nematicidal activity of ketamine in vitro and in vivo. Thus, confirming the nematicidal potential of the molecule present in the fungus P. chlamydosporia may consist a new method of controlling parasites.

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“…2) Pseudomonas aeruginosa is known for producing a wide variety of metabolites with antimicrobial and antioxidant effects. The identified volatile compounds, xanthoxylin, trans-2-decenoic acid, [1,2,4] oxadiazole, 5-benzyl-(thiophen-2-yl), dodecenoic acid, 3-nonynoic, pyrrolo [1,2-a]pyrazine-1,4-dione, hexahydro-3-(2methylpropyl), pentadecanoic acid and diisooctyl phthalate are recognised for possession of antimicrobial activity [50][51][52][53][54][55][56][57]. cis-9-Octadecenoic acid, 2-dodecenoic acid and 9-octadecenamide are reported to possess antioxidant property [58,59].…”

Section: Discussionmentioning

confidence: 99%

Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities

Nxumalo

Ngidi

Shandu

et al. 2020

BMC Complement Med Ther

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Background Endophytes, especially those that are found from ethnopharmacologically noteworthy medicinal plants have attracted attention due to their diverse bioactive metabolites of pharmacological importance. Methods This study aimed at isolating endophytic bacterium from the leaves of Anredera cordifolia CIX1 for its bioactive metabolites. The endophytic isolates were identified by 16S rRNA sequence and investigated for antibiotic sensitivity using different antibiotics. The secondary metabolites were evaluated for antibacterial activity against four bacterial strains. The 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis (3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used to assess their scavenging activities. The chemical components were analysed by gas chromatography-mass spectrometry (GC-MS). Results Out of 13 isolates, Isolate 1 was identified as Pseudomonas aeruginosa CP043328.1. It was resistant to clindamycin, ertapenem, penicillin G, amoxicillin, cephalothin and kanamycin but sensitive to imipenem, meropenem, and gentamycin. Its extract demonstrated antibacterial activity with minimum inhibitory concentration value of 0.098 against Bacillus cereus (ATCC 10102) and Staphylococcus aureus (ATCC 25925) and 0.391 mg/ml against Escherichia coli (ATCC 25922) and Proteus mirabilis (ATCC 25933). The extract revealed DPPH and ABTS scavenging activities with half maximal inhibitory concentration value of 0.650 mg/ml and 0.15 mg/ml, respectively. The GC-MS revealed a total of 15 compounds with diisooctyl phthalate (50.51%) and [1, 2, 4] oxadiazole, 5-benzyl-3 (10.44%) as major components. Conclusions P. aeruginosa CP043328.1 produced secondary metabolites with antibacterial and antioxidant activities.

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Antifungal and antibacterial activity of extracts produced from Diaporthe schini

Cited by 53 publications

References 30 publications

Synergistic Plant-Microbe Interactions between Endophytic Actinobacteria and Their Role in Plant Growth Promotion and Biological Control of Cotton under Salt Stress

Synergistic Plant-Microbe Interactions between Endophytic Actinobacteria and Their Role in Plant Growth Promotion and Biological Control of Cotton under Salt Stress

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new role

Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities

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