Antifungal and elicitor activities of p-hydroxybenzoic acid for the control of aflatoxigenic Aspergillus flavus in kiwifruit

Huo, Zailin; Shi, Xin-Chi; Wang, Yanxia; Jiang, Yong‐Hui; Zhu, Gui-Yang; Herrera‐Balandrano, Daniela D.; Wang, Suyan; Laborda, Pedro

doi:10.1016/j.foodres.2023.113331

Cited by 10 publications

(3 citation statements)

References 73 publications

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“…Many natural antifungal compounds can induce the accumulation of ROS in fungi, which may disrupt the imbalance of cellular redox homeostasis and ultimately lead to fungal cell death. For instance, Huo et al (2023) reported that burst of ROS levels induced by p -hydroxybenzoic acid in Aspergillus flavus cells could lead to cell death ( Huo et al, 2023 ). Notably, ROS is also an important factor in the effectiveness of photosensitizers.…”

Section: Discussionmentioning

confidence: 99%

“…The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Science and Technology Project of Guizhou Province (QKHJC-ZK [2023]YB117), the National Natural Science Foundation of China (grant number 32201565), and the Natural Science Special (Special Post) Research Fund of Guizhou University (grant number [2022]02) supported this study. The funding sources had no role in the study design (collection, analysis, and interpretation of data), report writing, and decision to submit the article for publication.…”

Section: Data Availability Statementmentioning

confidence: 99%

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The photoactivated antifungal activity and possible mode of action of sodium pheophorbide a on Diaporthe mahothocarpus causing leaf spot blight in Camellia oleifera

Shi,

Yang,

Zhang

et al. 2024

Front. Microbiol.

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IntroductionSodium pheophorbide a (SPA) is a natural plant-derived photosensitizer, with high photoactivated antifungal activity against some phytopathogenic fungi. However, its fungicidal effect on Diaporthe mahothocarpus, a novel pathogen that causes Camellia oleifera leaf spot blight, is unclear.MethodsIn the present study, we explored its inhibitory effects on spore germination and mycelial growth of D. mahothocarpus. Then we determined its effects on the cell membrane, mycelial morphology, redox homeostasis, and cell death through bioassay. Finally, RNA-seq was used further to elucidate its mode of action at the transcriptional level.ResultsWe found that SPA effectively inhibited the growth of D. mahothocarpus, with half-maximal effective concentrations to inhibit mycelial growth and spore germination of 1.059 and 2.287 mg/mL, respectively. After 1.0 mg/mL SPA treatment, the conductivity and malondialdehyde content of D. mahothocarpus were significantly increased. Scanning electron microscopy and transmission electron microscopy indicated that SPA significantly affected the morphology and ultrastructure of D. mahothocarpus hyphae, revealing that SPA can destroy the mycelial morphology and cell structure, especially the cell membrane of D. mahothocarpus. Furthermore, transcriptome analysis revealed that SPA significantly suppressed the expression of genes involved in morphology, cell membrane permeability, and oxidative stress. Then, we also found that SPA significantly promoted the accumulation of reactive oxygen species (ROS) in of D. mahothocarpus, while it decreased the content of reduced glutathione, inhibited the enzyme activities of superoxide dismutase and catalase, and exacerbated DNA damage. Annexin V-FITC/PI staining also confirmed that 1.0 mg/mL SPA could significantly induce apoptosis and necrosis.DiscussionGenerally, SPA can induce ROS-mediated oxidative stress and cell death, thus destroying the cell membrane and hyphal morphology, and ultimately inhibiting mycelial growth, which indicates that SPA has multiple modes of action, providing a scientific basis for the use of SPA as an alternative plant-derived photoactivated fungicide against C. oleifera leaf spot blight.

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Section: Discussionmentioning

confidence: 99%

Section: Data Availability Statementmentioning

confidence: 99%

The photoactivated antifungal activity and possible mode of action of sodium pheophorbide a on Diaporthe mahothocarpus causing leaf spot blight in Camellia oleifera

Shi,

Yang,

Zhang

et al. 2024

Front. Microbiol.

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show abstract

Section: Data Availability Statementmentioning

confidence: 99%

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An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

Sahu,

Sahu

et al. 2024

Chemistry & Biodiversity

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Nelumbo nucifera Gaertn is a recognised herbal plant in ancient medical sciences. Each portion of the plant leaf, flower, seed and rhizome is utilised for nutritional and medicinal purposes. The chemical compositions like phenol, alkaloids, glycoside, terpenoids and steroids have been isolated. The plant contains various nutritional values like lipids, proteins, amino acids, minerals, carbohydrates, and fatty acids. Traditional medicine confirms that the phytochemicals of plants give significant benefits to the treatment of various diseases such as leukoderma, smallpox, dysentery, haematemesis, coughing, haemorrhage, metrorrhagia, haematuria, fever, hyperlipidaemia, cholera, hepatopathy and hyperdipsia. To verify the traditional claims, researchers have conducted scientific biological in vivo and in vitro screenings, which have exhibited that the plant keeps various notable pharmacological activities such as anticancer, hepatoprotective, antioxidant, antiviral, hypolipidemic, anti‐obesity, antipyretic, hypoglycaemic, antifungal, anti‐inflammatory and antibacterial activities. This review, summaries the nutritional composition, chemical constituents and biological activities substantiated by the researchers done in vivo and in vitro.

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Antifungal and elicitor activities of p-hydroxybenzoic acid for the control of aflatoxigenic Aspergillus flavus in kiwifruit

Cited by 10 publications

References 73 publications

The photoactivated antifungal activity and possible mode of action of sodium pheophorbide a on Diaporthe mahothocarpus causing leaf spot blight in Camellia oleifera

The photoactivated antifungal activity and possible mode of action of sodium pheophorbide a on Diaporthe mahothocarpus causing leaf spot blight in Camellia oleifera

Table_2.DOCX

An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

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