Antifungal antibiotic hamycin increases susceptibility of Candida albicans to phagocytosis by murine macrophages

Dhuley, Jayant N

doi:10.1016/s0928-8244(98)00005-4

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Therefore, it was believed that the cell wall ergosterol or other components and drug interaction may be essential for hamycin to exert its antifungal action [8]. Hamycin has been shown to increase susceptibility of C. albicans to phagocytosis by murine macrophages [14]. Recently aerosolised liposomal hamycin has been shown e¡ective for the treatment of systemic Candida infections in mice [15].…”

Section: Introductionmentioning

confidence: 99%

Hamycin treatment of candidiasis in normal and diabetic rats

Dhuley¹

1999

FEMS Immunology and Medical Microbiology

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Hamycin, a heptaene antifungal antibiotic was compared with amphotericin B in the treatment of established systemic infection with Candida albicans in normal and diabetic rats. In normal rats, orally administered hamycin at 10 mg kg(-1) per day for 7 days reduced Candida colony counts in the kidneys and livers as well as amphotericin B did and was nearly as effective as amphotericin B in a 21-day treatment trial. There was no further reduction in Candida colony counts when normal rats were treated with hamycin at 25 mg kg(-1) twice a day for 7 days. In streptozotocin induced diabetic rats, hamycin at 20 mg kg(-1) per day for either 7 or 21 days compared favourably with amphotericin B in efficacy. Results of the present study suggest that oral hamycin may be useful in the treatment of established disseminated candidiasis in normal as well as diabetic hosts.

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Section: Introductionmentioning

confidence: 99%

Hamycin treatment of candidiasis in normal and diabetic rats

Dhuley¹

1999

FEMS Immunology and Medical Microbiology

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“…The phagocytosis protocol was based on that previously described by Dhuley (25). Primary BMM or RAW264.7 cells were grown on sterile coverslips in a 24-well plate.…”

Section: Phagocytosis Assaymentioning

confidence: 99%

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Wells

Salvage-Jones

et al. 2008

The Journal of Immunology

408

369

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The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-α by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.

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“…However, its a¤nity toward cholesterol in mammalian membranes may be responsible for its toxic e¡ects [5]. Recently, hamycin has been shown to increase the susceptibility of C. albicans to phagocytosis by murine macrophages [6].…”

Section: Introductionmentioning

confidence: 99%

Aerosolised liposomal hamycin for treatment of systemic Candida infections in mice

Dhuley¹

1999

FEMS Immunology and Medical Microbiology

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Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing hamycin liposomes. The drug, when administered twice daily for 2 h (0.68 mg kg(-1) body weight per day) on days 1, 2 and 3 post inoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given two 2-h treatments once a week for 4 weeks. A twice weekly 2-h small particle aerosol administration of hamycin for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.

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Antifungal antibiotic hamycin increases susceptibility of Candida albicans to phagocytosis by murine macrophages

Cited by 6 publications

References 7 publications

Hamycin treatment of candidiasis in normal and diabetic rats

Hamycin treatment of candidiasis in normal and diabetic rats

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

Aerosolised liposomal hamycin for treatment of systemic Candida infections in mice

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