Antifungal Bromophenols from Marine Red Alga <i>Symphyocladia latiuscula</i>

Xu, Xiuli; Yin, Liyuan; Gao, Junhai; Gao, Lijie; Song, Fuhang

doi:10.1002/cbdv.201300239

Cited by 32 publications

(20 citation statements)

References 11 publications

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“…The red alga Symphyocladia latiuscula from the coast of Qingdao, China, is a rich source of brominated phenols, and several new examples have been discovered ( 235 – 245 ) ( Figure 41 ) [ 90 , 91 , 92 ]. Bromocatechols 235 , 242 , and 244 display moderate activity against Candida albicans (MIC 37.5, 10, and 25 µg/mL, respectively) [ 90 , 91 , 92 ].…”

Section: Antifungal Activitymentioning

confidence: 99%

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Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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Section: Antifungal Activitymentioning

confidence: 99%

“… Structures of symphyocladins A–G ( 236 – 242 ) and other bromophenols from the red alga Symphyocladia latiuscula [ 90 , 91 , 92 ]. …”

Section: Antifungal Activitymentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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“…In addition, novel structurally-characterized marine molecules with antifungal MICs or IC 50 's greater than 10 µg/mL, 10 µM, or 10 µg/disk, which have been excluded from Table 1 and Figure 1 because of their weaker bioactivity: a new bromopyrrole alkaloid mukanadine G (IC 50 = 8-16 µg/mL) isolated from the Okinawan marine sponge Agelas sp. [53]; a new C24-acetylenic acid, biemnic acid (MIC = 100 µg/disk) isolated from the Red sea sponge Biemna ehrenbergi [148]; two sulfated steroid-aminoacid conjugates isolated from the Irish marine sponge Polymastia boletiformis (MIC = 100 µg/disk) against C. albicans [149]; two novel lysophospholids from the Guanxi sponge S. purpurea (IC 50 = 16 and 32 µg/mL) [84]; two new bromotyrosine alkaloids, tyrokeradine G and H, isolated from an Okinawan Verongid marine sponge (MIC = 16 and 32 µg/mL) [150]; two highly brominated polyphenols isolated from the Qingdao red alga S. latiuscula (MIC = 12.5, 25 µg/mL) [151]; one novel anhydride metabolite, tubingenoic anhydride A (MIC = 330 µM), from the Mediterranean fungus A. tubingensis (Strain OY907) [152]; and a novel compound terretrione D (MIC = 32 µg/mL) from a tunicate-derived fungus Penicillium sp. CYE-97 [153].…”

Section: Antifungal Activitymentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…[6] Sponges In addition to ten known compounds, the Australian sponge Callyspongia sp. was found to contain the novel callyspongic acid (22) and 23, 24 (Scheme 6).…”

Section: Algaementioning

confidence: 99%

A recent survey of naturally occurring organohalogen compounds

2015

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Environmental context. The general perception that nature does not produce compounds containing halogens -chlorine, bromine, iodine and fluorine -is now known to be erroneous. Modern isolation and identification techniques have led to the discovery of more than 5000 halogen-containing compounds from myriad marine and terrestrial plant and animal sources. Many of these compounds possess extraordinary biological activity, including anticancer, antiviral and antibacterial activity of potential human benefit.Abstract. This short review presents the naturally occurring organohalogen compounds discovered and characterised in 2014. They include compounds from both marine and terrestrial organisms, such as algae, sponges, corals, tunicates, bryozoans, fungi, bacteria, cyanobacteria and plants. Several novel structural types have been characterised. From only ,24 in 1968, naturally occurring organohalogens currently number more than 5000, and they continue to be discovered in all regions of the world. This review presents the 114 discovered organohalogens from natural sources in the year 2014.The enormous upsurge in the total number of natural organohalogens discovered since 1968 arises from several factors: (1) a worldwide revitalisation of natural products research in the search for new medicinal compounds from all aspects of our environment, (2) improved isolation, separation and identification techniques, (3) selective bioassays to identify biologically active extracts, (4) an awareness of folk medicine and ethnobotany for guidance to potentially important organisms.

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Antifungal Bromophenols from Marine Red Alga Symphyocladia latiuscula

Cited by 32 publications

References 11 publications

Biological Activity of Recently Discovered Halogenated Marine Natural Products

Biological Activity of Recently Discovered Halogenated Marine Natural Products

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

A recent survey of naturally occurring organohalogen compounds

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