Antifungal constituents from Nicotiana tabacum with the Wz locus infected by Phytophthora nicotianae

Yang, Yingli; Song, Biqing; Long, Jingyu; Fang, Duan-Huang; Hu, Dawei; Song, Na; Luo, Jifeng; Zeng, Jianmin; Wang, Yue‐Hu

doi:10.1016/j.rechem.2021.100196

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Alkaloid mixture, petroleum ether, and withanicandrin of N. physaloides Gaertn showed antifungal activities against S. cerevisiae and C. albicans [ 67 ]. Different compounds isolated from N. tabacum , such as alkaloids, nicotine, and capsidiol, have higher inhibitory activity against the fungus Phytophthora nicotianae [ 68 ]. C. longa has been reported to have toxic activity on fungi involved in the deterioration of crops by interfering with the development of mycelia [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Seedborne mycoflora of faba bean (Vicia fabae L.) and evaluation of plant extract and Trichoderma species against mycelium growth of selected fungi

Neme

Leta

Yones³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Seedborne mycoflora of faba bean (Vicia fabae L.) and evaluation of plant extract and Trichoderma species against mycelium growth of selected fungi

Neme

Leta

Yones³

et al. 2023

Heliyon

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“…Acid-induced neuronal damage in diabetes and cerebral ischemia is mediated by acid-sensitive ion channel 1a (ASIC1a), present on the plasma membrane as well as in mitochondria [41]. ASIC1a plays a certain role in regulating mitochondrial pore permeability by infl uencing the mechanisms that initiate mitochondrial cell death pathways [42,43].…”

mentioning

confidence: 99%

Pathogenetic Role of Disorders of Insulin Signaling Pathways and Diabetes-Associated Hyperglycemia in the Mechanisms of Diabetic Encephalopathy Formation and Hypersensitivity of the Brain to Ischemia-Reperfusion

Tkachuk¹,

Tkachuk²,

Nika³

et al. 2022

Arch. clin. med.

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The aim of the study was to analyze the literature data regarding the pathogenetic role of insulin signaling disorders and diabetes-associated hyperglycemia in the mechanisms of diabetic encephalopathy and hypersensitivity of the brain to ischemia-reperfusion. Conclusion. Analysis of the literature data shows a number of common links between the pathogenesis of diabetic encephalopathy and ischemic-reperfusion brain injury, which may, to some extent, explain the predisposition of diabetics to acute cerebral circulatory disorders and their adverse course. However, it is clear that the severity of such comorbid pathology cannot be explained only by the additive effect of individual links in the pathogenesis, which indicates the necessity for further in-depth study of its molecular-genetic aspects.

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Computational and experimental investigation of antibacterial and antifungal properties of Nicotiana tabacum extracts

et al. 2023

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The identification of novel anti-infective agents of synthetic and natural origin represents one of the main aims of contemporary drug discovery. In the current work, four different varieties of Nicotiana tabacum, namely, K399, SPG28, Swat No. 1, and Swat No. 2, were studied to assess the antibacterial and antifungal properties of their extracts. The extracts contain anthraquinones, alkaloids, saponins, terpenoids, tannins, resins, steroids, proteins, and carbohydrates, and the antibacterial and antifungal activities were evaluated toward four bacterial and four fungal strains. N. tabacum K399 showed the highest zone of inhibition against E. coli. Similarly, K399 showed the highest antifungal potential, as the highest zone of inhibition for the set was detected against C. albicans. Then, the underlying molecular mechanism was further investigated, and the extracts were tested for their inhibitory potential against urease, an enzyme which is conserved in bacteria and fungi. Additionally, computational tools were enrolled to assess the role of rutin and chlorogenic acid, which are among the main constituents of N. tabacum leaves, in interacting with urease through molecular docking. Combined together, the computational and experimental results support the antibacterial and antifungal potential of N. tabacum extracts, particularly, that obtained from K399 variety.

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Antifungal constituents from Nicotiana tabacum with the Wz locus infected by Phytophthora nicotianae

Cited by 4 publications

References 23 publications

Seedborne mycoflora of faba bean (Vicia fabae L.) and evaluation of plant extract and Trichoderma species against mycelium growth of selected fungi

Seedborne mycoflora of faba bean (Vicia fabae L.) and evaluation of plant extract and Trichoderma species against mycelium growth of selected fungi

Pathogenetic Role of Disorders of Insulin Signaling Pathways and Diabetes-Associated Hyperglycemia in the Mechanisms of Diabetic Encephalopathy Formation and Hypersensitivity of the Brain to Ischemia-Reperfusion

Computational and experimental investigation of antibacterial and antifungal properties of Nicotiana tabacum extracts

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