Antifungal constituents of <i>Clytostoma ramentaceum</i> and <i>Mansoa hirsuta</i>

Rocha, Alessandra Duarte; Oliveira, Alaı́de Braga de; Filho, José Dias de Souza; Lombardi, Júlio Antônio; Braga, Fernão Castro

doi:10.1002/ptr.1452

Cited by 47 publications

(38 citation statements)

References 23 publications

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“…Silva, unpublished data). In traditional medicine, the leaves of this species have been used to control diabetes (Chaves andReinhard 2003, Agra et al 2008) while the ethanol extract has inhibited the growth of Aspergillus niger and Fusarium oxysporum cultures (Rocha et al 2004). The antioxidant activity of M. hirsuta was also demonstrated by Braga et al (2000) while isolated proanthocyanidins were capable of inhibiting angiotensin-converting enzyme (ACE) (Campana et al 2009).…”

Section: Introductionmentioning

confidence: 98%

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Pereira

Queiroz

Siqueira

et al. 2017

An. Acad. Bras. Ciênc.

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Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotective and hypoglycemiant effects of raw extract, fractions and compounds from leaves of M. hirsuta. The cytogenotoxic effects of ursolic and oleanolic acids, the main phytotherapic components of this plant, were assessed. The raw extract and fractions presented steroids, saponins, flavonols, flavanonols, flavanones, xanthones, phenols, tannins, anthocyanins, anthocyanidins and flavonoids. The ethyl acetate fraction inhibited efficiently the cascade of lipid peroxidation while the hydroalcoholic fraction was richer in total phenols and more efficient in capturing 2,2-diphenyl-1-picrylhydrazyl ( · DPPH) and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS ·+ ) radicals. The isolated fraction of M. hirsuta also inhibited the α-amylase activity. Cytotoxic effects were absent in both raw extract and fractions while ursolic+oleanolic acids were efficient in protecting cells after exposure to hydrogen peroxide. Moreover, this mixture of acid shad no significant interference on the mitotic index and frequency of nuclear and/ or chromosomal abnormalities in Allium cepa test. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and oxidative pathologies, including diabetes.

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Section: Introductionmentioning

confidence: 98%

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Pereira

Queiroz

Siqueira

et al. 2017

An. Acad. Bras. Ciênc.

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“…The MIC of the H. ovalifolia extract against T. rubrum strains was 0.25 mg/mL and the E. uniflora extract exhibited antifungal activity against 19 of the 30 isolates at a concentration of 0.5 mg/mL. Rocha et al (2004) demonstrated antifungal activity of Clytostoma ramentaceum and Mansoa hirsuta (Bignoniaceae) when testing the low and medium polar fractions at concentrations of 0.1 to 0.3 mg/mL. Pacciaroni et al (2008) isolated several flavonoids from the aerial parts of Heterothalamus alienus and tested these compounds against clinical isolates of dermatophytes.…”

Section: Resultsmentioning

confidence: 91%

Isolation of flavonoids from Anemopaegma arvense (Vell) Stellf. ex de Souza and their antifungal activity against Trichophyton rubrum

Costanzo

Fernandes

Zingaretti

et al. 2013

Braz. J. Pharm. Sci.

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Anemopaegma arvense (Vell) Stellf. ex de Souza belongs to the family Bignoniaceae, and is popularly known as catuaba. To evaluate the cytotoxic and antimicrobial activity of A. arvense, fraction F3 and flavonoids 1 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside) (rutin) and flavonoid 2 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) were isolated from the leaves of this plant. Fraction F3 and flavonoids 1 and 2 exhibited no antibacterial activity. Furthermore, no cytotoxic activity of fraction 3 or flavonoids 1 and 2 was observed against the tumor cells tested. However, analysis of the antifungal activity of flavonoids 1 and 2 revealed minimum inhibitory concentrations of 0.5 and 0.25 mg/mL, respectively, against the Trichophyton rubrum strains tested (wild type and mutant). This study demonstrates for the first time the antifungal activity of isolated flavonoids, validating the same activity for A. arvense. Uniterms:Bignoniaceae. Anemopaegma arvense/phytochemistry. Catuaba/phytochemistry. Flavonoids/ antifungal activity. Plant extract/evaluation.Anemopaegma arvense pertence à família Bignoniaceae, sendo conhecida popularmente como Catuaba. Para avaliação de sua atividade citotóxica e antimicrobiana, a fração cromatográfica F3 e os flavonoides 1 (quercetina 3-O-α-L-ramnopiranosil-(1→6)-β-D-glucopiranosídeo) (rutina) e flavonoide 2 (quercetina 3-O-α-L-ramnopiranosil-(1→6)-β-D-galactopiranosídeo) foram isolados das folhas de A. arvense. A fração 3 e os flavonoides não apresentaram atividade antibacteriana. Nenhuma atividade citotóxica foi observada para a fração F3 e para os flavonoides, quando avaliados contra as células tumorais em teste. Entretanto, e considerando a atividade antifúngica, o flavonóide 1 apresentou valor de concentração inibitória mínima (CIM) de 0,5 mg/mL, enquanto o flavonóide 2, CIM de 0,25 mg/mL contra as cepas selvagem e mutante de Trichophyton rubrum, demonstrando, pela primeira vez, que os flavonoides isolados possuem atividade antifúngica, o que valida a mesma atividade para A. arvense.Unitermos: Bignoniaceae/fitoquímica. Anemopaegma arvense/fitoquímica. Catuaba/fitoquímica. Flavonóides/atividade antifúngica. Extrato vegetal/avaliação. INTRODUCTIONThe family Bignoniaceae comprises about 800 plant species that are found mainly in the Neotropical region (Gentry, 1980). In Brazil, several plants of this family are used in folk medicine as astringent and against fever, rheumatism, diarrhea, cancer and microbial infections (Pio Côrrea, Penna, 1969;Fenner et al., 2006). Anemopaegma arvense (Vell) Stellf. ex de Souza is a species of the family Bignoniaceae, which is popularly known as "catuaba". Commercially available formulations of this plant are used as aphrodisiac (Manabe et al., 1992). The major components identified in A. arvense are flavonoids, catuabins, alkaloids, tannins, and resins (Charam, 1987;Zanolari et al., 2005;Tabanca et al., 2007). Flavonoids are becoming the subject of anti-infective research and many groups have isolated and identified the str...

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“…& K. Schum and Mansoa hirsute DC. inhibited the growth of the fungi Aspergillus niger and Fusarium oxysporum (Rocha et al, 2004); a mixture of ellagitannins isolated from Punica granatum L. and two naphthoquinones isolated from Tabebuia avellanedae Lorenz ex Grisebach demonstrated antibacterial activity against multiresistant Staphylococcus aureus strains (Machado et al, 2003); the alcoholic extracts of the pods and flowers of Tecoma sambucifolia H.B.K. displayed cytotoxicity against a human hepatoma cell line (Alguacil et al, 2000); the biological screening of some fractions derived from the leaves and liana of Macfadyena unguiscati (L.) revealed antitumoral and antitrypanosomal activities (Duarte et al, 2000); and an aqueous ethanol extract of Jacaranda caucana Pittier showed in vivo antitumoral and in vitro cytotoxic activity against the P-388 lymphocytic leukemia system (Ogura et al, 1977).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial, Antifungal, and Cytotoxic Activities ofDistictis buccinatoria.

Rojas

Navarro

Alonso

et al. 2007

Pharmaceutical Biology

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The current study was undertaken to evaluate the in vitro antimicrobial and cytotoxic activity of six crude extracts obtained from the leaves and flowers of Distictis buccinatoria (DC.) A.H. Gentry (Bignoniaceae). Antimicrobial activity was tested against the Gram-positive bacteria Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis; the Gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, and Salmonella typhi; and the fungi Candida albicans, Trichophyton mentagrophytes, Trichophyton rubrum, and Aspergillus niger. The cytotoxic activity of each extract was determined using two human tumor cell lines in culture, nasopharyngeal carcinoma (KB) and colon carcinoma (HCT-15). The results showed that extracts from D. buccinatoria possess antimicrobial activity against the Gram-positive bacteria and against both dermatophyte fungal species. The strongest antibacterial activity observed was that of the dichloromethane extract prepared from flowers, and the best antifungal activity was demonstrated by the dichloromethane extract from the leaves. The hexane and dichloromethane extracts from the flowers exhibited cytotoxicity against KB cells. These results support the traditional folk medicinal uses of this plant.

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Antifungal constituents of Clytostoma ramentaceum and Mansoa hirsuta

Cited by 47 publications

References 23 publications

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Isolation of flavonoids from Anemopaegma arvense (Vell) Stellf. ex de Souza and their antifungal activity against Trichophyton rubrum

Antibacterial, Antifungal, and Cytotoxic Activities ofDistictis buccinatoria.

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