Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

Pfaller, Michael A.

doi:10.1016/j.amjmed.2011.11.001

Cited by 807 publications

(655 citation statements)

References 73 publications

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“…Also, patient outcome is poorer with isolates that are resistant. 6 To counter these problems, new antifungals should be developed against targets other than those of current antifungal therapeutics.…”

Section: -6 Whilementioning

confidence: 99%

Exploiting mitochondria as targets for the development of new antifungals

Calderone

2016

Virulence

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Section: -6 Whilementioning

confidence: 99%

Exploiting mitochondria as targets for the development of new antifungals

Calderone

2016

Virulence

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“…Simultaneously, during this period the rate of antibiotic resistance has significantly increased. [1][2][3] There are 2 main efforts underway to delay this public health disaster: major advocacy campaigns largely driven by the Infectious Diseases Society of America's 10 x '20 initiative (10 new antibiotics by 2020, endorsed by 36 medical societies) 4 and antimicrobial stewardship programs. 5 Antimicrobial stewardship programs are an effort to improve and promote the appropriate use of antibiotics through selection of optimal regimens including agent selection, dosing, duration of administration, and route of administration.…”

Section: Introductionmentioning

confidence: 99%

An Introductory Review Module For an Anti-Infectives Therapeutics Course

Leonard

Murphy

Zaeem

et al. 2012

American Journal of Pharmaceutical Education

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Objective. To determine whether an introductory review module using a hybrid-learning approach helped students learn infectious disease management in an anti-infectives therapeutics course.Design. An introductory module consisting of an online pharmacology review, pre-class assignment, 2 classroom lectures, and 1 case-based lecture was developed and implemented. Assessment. Among the 110 students who completed pre-and post-tests on the material covered, average scores increased from 71% to 83% ( p,0.0001). Performance on knowledge-based question improved for 8 out of 10 questions ( p,0.05) and student confidence increased from the first lecture to completion of the module ( p,0.001 for all comparisons). Of the 129 students who completed an evaluation of the introductory module, 98% strongly agreed or agreed that the content was essential for course success. Conclusion. The addition of an introductory module using a hybrid-learning approach to review and solidify concepts of medical microbiology and pharmacology provided the foundation necessary for success in an infectious diseases module.

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“…[1][2][3] Presently, fungi have become the fourth main cause of hospitalacquired infections. 4,5 Among the fungal pathogens, Candida spp is prominent, and Candida albicans is a major pathogen. 1,6 C. albicans is a commensal fungus that colonize on gastrointestinal/genital mucosa of mammalians without causing disease in most healthy individuals, but in case the host defense is weakened under certain circumstances can C. albicans become pathogenic.…”

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confidence: 99%