Antifungal drugs in the aquatic environment: A review on sources, occurrence, toxicity, health effects, removal strategies and future challenges

Wroński, Michał; Trawiński, Jakub; Skibiński, Robert

doi:10.1016/j.jhazmat.2023.133167

Cited by 8 publications

(1 citation statement)

References 175 publications

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“…However, despite its efficacy in combating fungal infections, concern arises regarding the widespread use of miconazole and its potential impact on both human health and nontarget organisms. This is particularly pertinent as miconazole has been detected in various environmental samples, raising concerns about its presence and potential impacts [2]. The dissemination of antifungal medications into the environment may potentially contribute to the spread of antimicrobial resistance [3].…”

Section: Introductionmentioning

confidence: 99%

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Wroński,

Trawiński,

Skibiński

2024

Molecules

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The main objective of this study was to investigate the metabolism of miconazole, an azole antifungal drug. Miconazole was subjected to incubation with human liver microsomes (HLM) to mimic phase I metabolism reactions for the first time. Employing a combination of an HLM assay and UHPLC-HRMS analysis enabled the identification of seven metabolites of miconazole, undescribed so far. Throughout the incubation with HLM, miconazole underwent biotransformation reactions including hydroxylation of the benzene ring and oxidation of the imidazole moiety, along with its subsequent degradation. Additionally, based on the obtained results, screen-printed electrodes (SPEs) were optimized to simulate the same biotransformation reactions, by the use of a simple, fast, and cheap electrochemical method. The potential toxicity of the identified metabolites was assessed using various in silico models.

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Section: Introductionmentioning

confidence: 99%

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Wroński,

Trawiński,

Skibiński

2024

Molecules

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Synthesis of Nanocomposite Based Polysaccharide and Performance Evaluation for the Removal of Various Drug from Pharmaceuticals Wastewater

Moradi,

Mhdavi,

Sedaghat

2024

ChemistrySelect

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The present study performed synthesis and characterization nanocomposite based polysaccharide Chitosan/Agar and Chitosan/Agar/SiO2 nanoparticles as adsorbents for remove amoxicillin and naproxen as the pharmaceuticals from an aqueous solution. The structure and morphology of nanocomposite were investigated using X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX), Fourier‐transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), Field Emission Scanning Electron Microscopes (FE‐SEM) and Dynamic light scattering (DLS). The removal performance of the Chitosan/Agar and Chitosan/Agar/SiO2 nanoparticles nanocomposite as adsorbent for removing amoxicillin and naproxen as sample of pharmaceutical industry effluents in aqueous solutions was investigated under different influence factors, including contact time, initial concentration, pH conditions and temperature. The maximum adsorption removal for amoxicillin with Agar/Chitosan and Agar/Chitosan/SiO2 nanocomposite at initial concentrations of 20 mg/l was 97.85 % and 87.9 %, respectively. With increasing temperature from 10 to 30°C, the removal efficiency for naproxen for both adsorbents is 99 %. The prepared nanocomposites showed good performance in adsorbing naproxen and amoxicillin. The maximum adsorption efficiency of nanocomposite was 99 % and 91 % for naproxen and amoxicillin, respectively. The optimum condition for pharmaceuticals removal by the nanocomposite was initial concentration: 20 mg/l, adsorbent dose: 0.05 g, contact time: 10 min, and pH=6.

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Demethylation Inhibitor Fungicides Have a Significantly Detrimental Impact on Population Growth and Composition of Nectar Microbial Communities

Quevedo-Caraballo,

Roldán,

Álvarez-Pérez

2024

Microb Ecol

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Antifungal drugs in the aquatic environment: A review on sources, occurrence, toxicity, health effects, removal strategies and future challenges

Cited by 8 publications

References 175 publications

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Synthesis of Nanocomposite Based Polysaccharide and Performance Evaluation for the Removal of Various Drug from Pharmaceuticals Wastewater

Demethylation Inhibitor Fungicides Have a Significantly Detrimental Impact on Population Growth and Composition of Nectar Microbial Communities

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