Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach

Filho, Abrahão Alves de Oliveira; Oliveira, Heloísa Mara Batista Fernandes de; Medeiros, Cássio Ilan Soares; Pessôa, Hilzeth de Luna Freire; Júnior, José Pinto de Siqueira; Lima, Edeltrudes de Oliveira

doi:10.14393/bj-v33n1a2017-33851

Cited by 2 publications

(2 citation statements)

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“…The literature reports both insecticide and bacteriostatic activity for citronellol (Oliveira-Filho et al, 2017;Robledo et al, 2005;Alviano et al, 2005;Park et al, 2012). Haida et al (2007) suggest that the essential oil obtained from the plant Cymbopogon citratus has citronellol as one of its chemical components, having antibacterial activity against some 20 bacterial species.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of cariogenic microorganisms to phytoconstituents

et al. 2018

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This study aimed to evaluate the in vitro antibacterial activity of the phytochemicals thymol, linalool, and citronellol against Streptococcus mutans, Streptococcus salivarius and Streptococcus oralis. Disk diffusion screening on solid medium and measurement of the diameter of the bacterial growth inhibition halos was the technique utilized. The Minimum Inhibitory Concentration (MIC) of the substances was determined using serial substance dilutions and microdilution technique in Brain Heart Infusion culture medium. After incubation for 24 hours in an oven at 37 °C, plate reading was completed and confirmed by visual method using 2,3,5 triphenyl tetrazolium chloride dye. The Minimum Bactericidal Concentration (MBC) was determined from MIC subcultures. Assays were performed in triplicate, and chlorhexidine was used as a positive control. The diameters in mm of the growth inhibition halos ranged between 7.3 and 10.7 for S. mutans, 7.3 and 10.0 for S. oralis, and 8.2 and 9.8 for S. salivarius. The MIC and MBC values obtained converged , ranging from maximum values in the presence of Linalool (1,250.0 mg/mL, 2,500.0 mg/mL and 2,500.0 mg/mL, respectively, for S. mutans, S. oralis, and S. salivarius); and minimum values with Thymol (312.5 μg/ml, 156.2 μg/mL and 156.2 μg/ml, respectively for S. mutans, S. oralis, and S. salivarius). All the tested phytochemicals displayed antibacterial activity, thus representing substances with potential applications in preventing tooth decay.Keywords: preventive dentistry, dental caries, citronellol, linalool, thymol. Susceptibilidade de microrganismos cariogênicos a fitoconstituintes ResumoEste estudo objetivou avaliar a atividade antibacteriana in vitro dos fitoquímicos timol, linalol e citronelol sobre Streptococcus mutans, Streptococcus salivaris e Streptococcus oralis. Utilizou-se a técnica de discos de difusão em meio sólido e medição do diâmetro dos halos de inibição. A concentração inibitória mínima (CIM) das substâncias foi determinada utilizando diluições em série das substâncias e técnica de microdiluição em meio de cultura de Brain Heart Infusion. Após incubação durante 24 horas em estufa a 37 °C, a leitura da placa foi confirmada pelo método visual usando o corante 2,3,5 trifenil cloreto de tetrazólio. A concentração bactericida mínima (CBM) foi determinada a partir de subculturas de MIC. Os ensaios foram realizados em triplicata, e clorexidina foi usada como um controle positivo. Os diâmetros dos halos de inibição do crescimento variaram entre 7,3 e 10,7 por S. mutans, 7,3 e 10,0 por S. oralis, e 8,2 e 9,8 para S. salivaris. Os valores de CIM e CBM obtidos variaram de valores máximos na presença de linalol (1.250,0 mg/mL, 2.500.0 mg/mL e 2.500.0 mg/mL, respectivamente, para o S. mutans, S oralis e S. salivaris); a valores mínimos com timol (312,5 μg/ml, 156,2 μg/mL e 156,2 μg

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Section: Discussionmentioning

confidence: 99%

Susceptibility of cariogenic microorganisms to phytoconstituents

et al. 2018

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“…Essential oil molecules that have been known to have activity as anticancer agents include citronellal (Oliveira Filho et al, 2017) (Crespo-Ortiz & Wei, 2012) (Ho et al, 2020), limonene (Jia et al, 2013) (Araújo-Filho et al, 2021, eugenol (Zari et al, 2021), and methyl salicylate (Yeasmin & Choi, 2020) (Karalis et al, 2020) as major components that have the potential to be combined into hybrid molecules. One method of synthesis that involves combining two essential molecules through an esterification reaction.…”

Section: Introductionmentioning

confidence: 99%

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

Azhar,

Warsito,

Srihardyastutie

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Design of new compounds as active ingredients of drugs must be selective and efficient to achieve therapeutic efficacy and minimize resulting side effects. Hybridization synthesis approaches using major components of essential oils can reliably generate new molecules that are superior as active ingredients of anti-cancer drugs due to their cytotoxic properties. This study synthesized a hybrid molecule of citronellyl salicylate by an esterification reaction using Steglich and Fisher method under ultrasonic assistance. The Steglich esterification is more efficient in producing citronellyl salicylate during 30 minutes reaction, yield 12.45%. Analysis of the synthesized product by FTIR is characterized by the presence of typical absorptions of the ester group at ῡ 1650 cm-1 and 1270 cm-1, while LC ESI-MS shows m/z 294 is indicated [M+NH4]+. Anticancer activity was tested in-silico for protein receptors MMP-9, MMP-2, Cyclin-A, p53, and BAK using Molecular Docking Pyrx 9.0 and the highest activity was shown binding affinity value -8.4 kcal/mol for the MMP-9 protein receptor. Similarly, the results of the in vitro activity assay of citronellyl salicylate to 4T1 breast cancer cells showed that the morphology of cancer cells was damaged and the viability of cancer cells was lower than that of normal cells

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Antifungal effect of 7-hydroxycitronellal against C. Tropicalis strains: an in vitro approach

Cited by 2 publications

References 14 publications

Susceptibility of cariogenic microorganisms to phytoconstituents

Susceptibility of cariogenic microorganisms to phytoconstituents

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

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