ANTIFUNGAL EFFECT OF ETHANOL PLANT EXTRACT ON &lt;i&gt;CANDIDA&lt;/i&gt; SP

Al-Judaibi,

doi:10.3844/ajabssp.2014.277.283

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…Many works associated with selected parts of the herb or plant aimed to determine the content of specific compounds responsible for required biological activity [ 18 , 19 , 20 ]. Studies on natural extracts from many plants have proven their antioxidant, antimicrobial, antifungal, antibacterial, anti-inflammatory, antipyretic and analgesic activity and, as a consequence, wide potential application [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Among many plants with various biological effects, Mentha piperita L. and Urtica dioica L. are species with intensive antioxidant and anti-aging properties associated with the presence of various phytochemicals, such as terpenoids, carotenoids, tannins, vitamins, acids and many derivatives [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti–Aging Activity of Freeze–Dried Alcohol–Water Extracts from Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.) in Elastomer Vulcanizates

et al. 2022

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The research article aimed to examine the antioxidant nature of freeze–dried extracts from Urtica dioica L. and Mentha piperita L. and to present a deep characterization of their influence on the properties of natural rubber–based vulcanizates before and after simulated aging processes. Natural extracts were prepared in three solvent systems at selected volume ratios: water (100), methanol–water (50/50), ethanol–water (50/50), which were further lyophilized and used as additive to natural rubber mixtures. Freeze–dried materials were investigated by UV–VIS diffuse reflectance spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), thermal stability by thermogravimetric analysis (TGA). Antioxidant activity and total phenolic content (TPC) were also examined. Prepared samples were subjected to accelerated simulated degradation processes by using ultraviolet and thermo-oxidative aging. Vulcanizates resistance to degradation effects was determined by the study of cross-linking density (equilibrium swelling method), mechanical properties (tensile strength, elongation at break) and color change in comparison with the results of the reference samples. The research showed that analyzed extracts are characterized by a high content of polyphenols and antioxidant activity, thus have a protective influence on elastomer vulcanizates against damaging effects of aging processes, which consequently extends the lifetime of materials.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti–Aging Activity of Freeze–Dried Alcohol–Water Extracts from Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.) in Elastomer Vulcanizates

et al. 2022

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“…In México, it is mainly used to treat diabetes through leaf infusion intake [1,2]. As a result of its broad usage in traditional medicine, the bark, flower, and leaves of the plant have been subject to in vivo and in vitro analysis, showing pharmacological properties that include antidiabetic and hypoglycemic [3][4][5], antioxidant [6][7][8], antimicrobial and antifungal [9][10][11][12], anti-inflammatory [13,14], cardioprotective [15], hepatoprotective [16], antiulcer [17], and anticancer [18].…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Tecoma stans Extracts: Bioactive Properties Preservation and Physical Characterization Analysis

García-Jiménez,

Luna-Guevara,

Luna-Guevara

et al. 2024

Foods

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Bioactive compounds from medicinal plants have applications in the development of functional foods. However, since they are unstable, encapsulation is used as a conservation alternative. This work aimed to assess the bioactive properties (antioxidant and hypoglycemic) of different extracts, including the infusion, as well as their spray-dried microencapsulates from Tecoma stans leaves. A factorial design was proposed to determine the best extraction conditions, based on ABTS and DPPH inhibition. Maltodextrin (MD), arabic gum (AG), and a 1:1 blend (MD:AG) were used as encapsulating agents. Moreover, characterization through physicochemical properties, gas chromatography/mass spectrometry (GC-MS) and scanning electron microscopy (SEM) of the best two powders based on the bioactive properties were analyzed. The results showed that the combination of stirring, water, and 5 min provided the highest inhibition to ABTS and DPPH (35.64 ± 1.25 mg Trolox/g d.s. and 2.77 ± 0.01 g Trolox/g d.s., respectively). Spray drying decreased the antioxidant activity of the extract while preserving it in the infusion. The encapsulated infusion with MD:AG had the highest hypoglycemic activity as it presented the lowest glycemic index (GI = 47). According to the results, the microencapsulates could potentially be added in foods to enhance nutritional quality and prevent/treat ailments.

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“…Extracts and compounds (tannins, flavonoids, alkaloids, quinones, and saponins) from this plant have shown antibacterial, antifungal, antitumoral, and hypoglycemic activities ( Binutu and Lajubutu, 1994 ; Aguilar-Santamaría et al, 2009 ; Ramesh et al, 2009 ; Kameshwaran et al, 2012 ). For example, an ethanolic extract from T. stans leaves showed inhibitory and fungicidal effect on Candida tropicalis and C. albicans ( Al-Judaibi and Al-Yousef, 2014 ). Additionally, T. stans is considered a plant resistant to pests and pathogens ( Gilman and Watson, 1994 ) and thus is attractive for research purposes involving defense proteins.…”

Section: Introductionmentioning

confidence: 99%

A Trypsin Inhibitor from Tecoma stans Leaves Inhibits Growth and Promotes ATP Depletion and Lipid Peroxidation in Candida albicans and Candida krusei

et al. 2016

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Tecoma stans (yellow elder) has shown medicinal properties and antimicrobial activity. Previous reports on antifungal activity of T. stans preparations and presence of trypsin inhibitor activity from T. stans leaves stimulated the investigation reported here. In this work, we proceeded to the purification and characterization of a trypsin inhibitor (TesTI), which was investigated for anti-Candida activity. Finally, in order to determine the potential of TesTI as a new natural chemotherapeutic product, its cytotoxicity to human peripheral blood mononuclear cells (PBMCs) was evaluated. TesTI was isolated from saline extract by ammonium sulfate fractionation followed by ion exchange and gel filtration chromatographies. Antifungal activity was evaluated by determining the minimal inhibitory (MIC) and fungicide (MFC) concentrations using fungal cultures containing only yeast form or both yeast and hyphal forms. Candida cells treated with TesTI were evaluated for intracellular ATP levels and lipid peroxidation. Cytotoxicity of TesTI to PBMCs was evaluated by MTT assay. TesTI (39.8 kDa, pI 3.41, Ki 43 nM) inhibited similarly the growth of both C. albicans and C. krusei culture types at MIC of 100 μg/mL. The MFCs were 200 μg/mL for C. albicans and C. krusei. Time-response curves revealed that TesTI (at MIC) was more effective at inhibiting the replication of C. albicans cells. At MIC, TesTI promoted reduction of ATP levels and lipid peroxidation in the Candida cells, being not cytotoxic to PBMCs. In conclusion, TesTI is an antifungal agent against C. albicans and C. krusei, without toxicity to human cells.

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ANTIFUNGAL EFFECT OF ETHANOL PLANT EXTRACT ON <i>CANDIDA</i> SP

Cited by 8 publications

References 22 publications

Antioxidant and Anti–Aging Activity of Freeze–Dried Alcohol–Water Extracts from Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.) in Elastomer Vulcanizates

Antioxidant and Anti–Aging Activity of Freeze–Dried Alcohol–Water Extracts from Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.) in Elastomer Vulcanizates

Microencapsulation of Tecoma stans Extracts: Bioactive Properties Preservation and Physical Characterization Analysis

A Trypsin Inhibitor from Tecoma stans Leaves Inhibits Growth and Promotes ATP Depletion and Lipid Peroxidation in Candida albicans and Candida krusei

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