Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii

Hwang, Bomi; Lee, Jun-Young; Liu, Qing-He; Woo, Eun‐Rhan; Lee, Dong Gun

doi:10.3390/molecules15053507

Cited by 61 publications

(32 citation statements)

References 26 publications

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“…Hwang et al . () showed that pinoresinol inhibits the growth of Candida albicans by causing damage to the fungal plasma membrane. Other limited studies revealed the growth inhibitory effect of lignans against different fungi, including mycotoxin producers such as Aspergillus flavus , A. niger and F. verticillioides (Céspedes et al .…”

Section: Introductionmentioning

confidence: 99%

Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum

Kulik

Buśko

Pszczółkowska

et al. 2014

Lett Appl Microbiol

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Significance and Impact of the Study: Knowledge of the regulation of trichothecene production in Fusarium graminearum by environmental cues is key to the design of novel strategies to reduce mycotoxin levels in grains. Here, we show that the lignans pinoresinol and secoisolariciresinol, which occur in wheat grains, inhibit radial growth and decrease trichothecene levels in five F. graminearum strains. RT-qPCR analysis reveals that the reduction in trichothecene level in lignan-treated fungal cultures is associated with decreased mRNA transcript levels for the tri4, tri5 and tri11 genes that are involved in the trichothecene biosynthesis pathway. AbstractLignans are a group of diphenolic compounds with anticancer and antioxidant properties which are present in various grains, although their effect on toxigenic fungi has been poorly examined to date. In this study, the impact of the plant lignans pinoresinol and secoisolariciresinol on growth and trichothecene biosynthesis by five Fusarium graminearum strains of different chemotypes was examined in vitro. Both tested lignans exhibited radial growth inhibition against the fungal strains. RT-qPCR analyses of tri4, tri5 and tri11 genes encoding the first steps of the trichothecene biosynthesis pathway revealed a decrease in tri mRNA levels in lignan-treated fungal cultures. Correspondingly, decreased accumulation of toxins in lignan-treated cultures was confirmed by GC-MS analysis. This is the first study to demonstrate the inhibitory effect of both pinoresinol and secoisolariciresinol on growth and trichothecene biosynthesis in F. graminearum.

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Section: Introductionmentioning

confidence: 99%

Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum

Kulik

Buśko

Pszczółkowska

et al. 2014

Lett Appl Microbiol

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“…Furthermore, 2 attenuates inflammatory responses of microglia and could be useful in modulation of inflammatory status in brain disorders (Jung et al, 2010). Lignan 2 was shown to possess fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans (Hwang et al, 2010). It exhibited inhibitory activity against rat intestinal maltase with an IC 50 value of 34.3 μM (Wikul et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Cycas aenigma

Ng¹,

Agoo²,

Shen³

et al. 2015

J App Pharm Sci

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Chemical investigation of Cycas aenigma, a plant endemic to the Philippines, led to the isolation of a rare neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol (1), pinoresinol (2), and fatty alcohols (3) from the leaflets; and triglycerols (4), and a mixture of β-sitosterol (5a) and stigmasterol (5b) from the petiole and rachis. The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy, while those of 2-5b were identified by comparison of their 1 H and/or 13 C NMR data with literature data.

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“…The risk of certain types of breast cancer in premenopausal women is lowered by pinoresinol ingestion (Brown 2012). Pinoresinol presents activity against both human pathogenic fungi (Hwang et al 2010) and Gram-positive bacteria (Céspedes et al 2006). Secoisolariciresinol exhibited a significant antifungal activity on fungi of white rooting and wood staining (Céspedes et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Components of Pinus pinaster Wood

Conde¹,

Fang²,

Hemming³

et al. 2013

BioResources

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Aqueous fractionation of wood has been proposed as a suitable processing method for biorefineries. When treatments are performed under low severity conditions, water-soluble components (which could be detrimental in further processing stages) are removed, whereas polysaccharides, lignin, and other water-insoluble constituents remain in solid phase with little alteration. In order to explore the presence of added-value products in aqueous extracts from Pinus pinaster wood, different samples (heartwood and sapwood with and without knots) were extracted with water at 130 to 140 ºC, and the resulting solutions were assayed for yield and composition (by GC-FID, GC-MS, and HPLC). The major extract components, such as polysaccharide-derived products, simple phenolics, stilbenes, lignans, flavonoids, organic acids, jubaviones, steryl esters, and triglycerides, were identified and quantified. In order to assess a possible application of the extracts, their antioxidant activity was measured using the Trolox Equivalent Antioxidant Capacity assay.

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Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii

Cited by 61 publications

References 26 publications

Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum

Plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum

Chemical Constituents of Cycas aenigma

Water-Soluble Components of Pinus pinaster Wood

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