Antifungal effects of ZnO, TiO2 and ZnO-TiO2 nanostructures on Aspergillus flavus

Ilkhechi, Nasrollah Najibi; Mozammel, Mahdi; Khosroushahi, Ahmad Yari

doi:10.1016/j.pestbp.2021.104869

Cited by 40 publications

(23 citation statements)

References 34 publications

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“…Nanoparticles that pass through the cell wall are not fully understood. However, their transport, diffusion and endocytosis, and entry into the cell can lead to the production of reactive oxygen species (ROS) and thus interfere with the function of many intracellular organs [29,30]. Reactive oxygen species seem to play a major role in antifungal activity.…”

Section: Resultsmentioning

confidence: 99%

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Ghorbani

Gorji

Mobarakeh

et al. 2022

Journal of Nanomaterials

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Increased resistance of fungal pathogens to common antimicrobial agents is known as one of the most important human problems. Due to the limited variety of antifungal drugs available, the identification and use of new antifungal drugs are essential. This study aimed to determine the optimal conditions for synthesizing a novel nanocomposite of xanthan gum/ZnO/TiO2with the highest antifungal activity against Candida albicans (C. albicans). For this purpose, nine experiments were designed using the Taguchi method. In the designed experiments, three factors of xanthan gum, ZnO, and TiO2nanoparticles have been investigated at three different levels, and the best ratio with the highest antifungal activity was determined. The results showed that in the presence of the synthesized nanocomposite in experiment 3 (xanthan gum 0.01 M, ZnO 0.09 M, and TiO2 0.09 M), the inhibition of fungal growth reached 92.51%. The properties of the synthesized nanocomposite and its components were investigated using different characterization methods, which confirmed the formation of nanocomposites with desirable properties. The antifungal activity results showed that the synthesized nanocomposite as an antifungal agent has an effective performance and can be used well in various fields.

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Section: Resultsmentioning

confidence: 99%

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Ghorbani

Gorji

Mobarakeh

et al. 2022

Journal of Nanomaterials

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“…For example, Xie et al reported that C. albicans cells were mechanically ruptured when interacting with ZnO nanostructured substrates (a polygonal column structure with a height of 3–5 μm and a width of 100–200 nm) [ 54 ]. Upon interaction with ZnO-TiO 2 -nanostructured surfaces, it was discovered that the A. flavus conidia lost their typical round morphology [ 55 ]. In addition to the intrinsic mechanism of the ROS-mediated antimicrobial effects, the physical orientation (an extended tubular shape) of MoS 2 has also been shown to play a substantial role in imparting the fungicidal effects of these surfaces toward Alternaria alternata cells [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Nanopillar Silicon Surfaces Rupture Fungal Spores

Linklater

Aburto‐Medina

et al. 2023

IJMS

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The mechano-bactericidal action of nanostructured surfaces is well-documented; however, synthetic nanostructured surfaces have not yet been explored for their antifungal properties toward filamentous fungal species. In this study, we developed a biomimetic nanostructured surface inspired by dragonfly wings. A high-aspect-ratio nanopillar topography was created on silicon (nano-Si) surfaces using inductively coupled plasma reactive ion etching (ICP RIE). To mimic the superhydrophobic nature of insect wings, the nano-Si was further functionalised with trichloro(1H,1H,2H,2H-perfluorooctyl)silane (PFTS). The viability of Aspergillus brasiliensis spores, in contact with either hydrophobic or hydrophilic nano-Si surfaces, was determined using a combination of standard microbiological assays, confocal laser scanning microscopy (CLSM), and focused ion beam scanning electron microscopy (FIB-SEM). Results indicated the breakdown of the fungal spore membrane upon contact with the hydrophilic nano-Si surfaces. By contrast, hydrophobised nano-Si surfaces prevented the initial attachment of the fungal conidia. Hydrophilic nano-Si surfaces exhibited both antifungal and fungicidal properties toward attached A. brasisiensis spores via a 4-fold reduction of attached spores and approximately 9-fold reduction of viable conidia from initial solution after 24 h compared to their planar Si counterparts. Thus, we reveal, for the first time, the physical rupturing of attaching fungal spores by biomimetic hydrophilic nanostructured surfaces.

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“…In the frame of this review, we will focus on this last one. Many studies indicated that intracellular ROS production occurs in the presence of metallic NPs and that this production is influenced by the type and specific surface of nanoparticles [ 79 ]. NPs can generate ROS due to transition metals on their surface through Fenton or Haber–Weiss reactions [ 80 ].…”

Section: Targeting Fungi Through Ros Productionmentioning

confidence: 99%

Redox-Based Strategies against Infections by Eukaryotic Pathogens

Vallières

Golinelli-Cohen

Guittet

et al. 2023

Genes

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Redox homeostasis is an equilibrium between reducing and oxidizing reactions within cells. It is an essential, dynamic process, which allows proper cellular reactions and regulates biological responses. Unbalanced redox homeostasis is the hallmark of many diseases, including cancer or inflammatory responses, and can eventually lead to cell death. Specifically, disrupting redox balance, essentially by increasing pro-oxidative molecules and favouring hyperoxidation, is a smart strategy to eliminate cells and has been used for cancer treatment, for example. Selectivity between cancer and normal cells thus appears crucial to avoid toxicity as much as possible. Redox-based approaches are also employed in the case of infectious diseases to tackle the pathogens specifically, with limited impacts on host cells. In this review, we focus on recent advances in redox-based strategies to fight eukaryotic pathogens, especially fungi and eukaryotic parasites. We report molecules recently described for causing or being associated with compromising redox homeostasis in pathogens and discuss therapeutic possibilities.

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Antifungal effects of ZnO, TiO2 and ZnO-TiO2 nanostructures on Aspergillus flavus

Cited by 40 publications

References 34 publications

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Biomimetic Nanopillar Silicon Surfaces Rupture Fungal Spores

Redox-Based Strategies against Infections by Eukaryotic Pathogens

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Antifungal effects of ZnO, TiO2 and ZnO-TiO2 nanostructures on Aspergillus flavus

Cited by 40 publications

References 34 publications

Optimized Synthesis of Xanthan gum/ZnO/TiO2Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Optimized Synthesis of Xanthan gum/ZnO/TiO2Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Biomimetic Nanopillar Silicon Surfaces Rupture Fungal Spores

Redox-Based Strategies against Infections by Eukaryotic Pathogens

Contact Info

Product

Resources

About

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans

Optimized Synthesis of Xanthan gum/ZnO/TiO₂Nanocomposite with High Antifungal Activity against Pathogenic Candida albicans