Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus<i>Malassezia restricta</i>

Do, Eunsoo; Lee, Hyun Gee; Park, Minji; Cho, Yong‐Joon; Kim, Donghyeun; Park, Se-Ho; Eun, Dae-Kyung; Park, Taehun; An, Shi; Jung, Woo-Hwan

doi:10.1080/12298093.2019.1625175

Cited by 10 publications

(3 citation statements)

References 41 publications

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“…In this article, novel quaternized carbon dots (QCD) were prepared through a simple carboxylamine reaction between lauryl betaine (LB) and amine‐functionalized carbon dots (AFCD) [28]. LB is a natural product commonly found in human diets, extracted from Beta vulgaris [31]. Previous research had shown that LB exhibited antibacterial activity against Escherichia coli , Salmonella typhimurium , and Staphylococcus aureus [32, 33].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023

Zhong,

Cheng,

Liu

et al. 2023

Electrophoresis

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To gain a deeper understanding of the current status of research on Traditional Chinese Medicine (TCM) and nanoparticles, we conducted a bibliometric study. We conducted a literature search in the Web of Science (WOS) for publications related to TCM and nanoparticles from 1992 to 2023. The data, including countries of publication, research institutions, journals, citations, and keywords, were analyzed using the Bibliometrix R‐4.0 software package. We performed an analysis to identify the co‐occurrence of keywords in the documents including their titles and abstracts. From 2005 to 2023, a total of 309 publications were included, with an average annual growth rate of 4.25%. The majority of these publications were published in Q1 journals (72, 47.06%) and Q2 journals (45, 29.41%). Among the 309 publications, 22 articles (7.12%) had an impact factor greater than 10, while 78 articles (25.24%) had an impact factor greater than 5. The analysis of international collaboration networks revealed limited international cooperation, with most collaborations occurring between institutions in China, the United States, and Australia. These 309 publications involved a total of 438 research institutions, with Chinese research institutions being the most prolific contributors. In this study, a total of 309 publications were included, comprising 1142 author keywords and 1175 keywords plus. Factor analysis of the 1175 keywords plus revealed that they could be grouped into five categories: one category included terms such as “oxide” and “zinc,” another category included terms like “lipid” and “acid,” a third category included terms such as “improve” and “enhance,” a fourth category included terms like “silica” and “mesoporous,” and the fifth category included terms like “PLGA” and “immune.” Research on nanoparticles in TCM has been gradually gaining popularity. Currently, most of the research in this field is conducted in China, with limited international collaboration. The majority of TCM nanoparticle research focuses on individual herbal compounds, while research on nanoparticle formulations of traditional herbal prescriptions is relatively scarce.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023

Zhong,

Cheng,

Liu

et al. 2023

Electrophoresis

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“…Betaine is used as a source of carbon and energy source by fungi as reported by [ 57 ]. Furthermore, the antibacterial activity of betaine has been reported [ 58 ] as well as its activity against skin-associated fungus [ 59 ]. In addition, betaine has an important medicinal value in several human diseases, such as obesity, diabetes, cancer, Alzheimer’s and gastrointestinal diseases [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Isolation, Characterization, and Metabolic Profiling of Ceratorhiza hydrophila from the Aquatic Plant Myriophyllum spicatum

2022

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The goal of the present study was to investigate the antibacterial properties, enzyme production, and metabolic profiling of a new Ceratorhiza hydrophila strain isolated from the submerged aquatic plant Myriophyllum spicatum . Furthermore, the fungus' morphological characterization and DNA sequencing have been described. The fungus has been identified and submitted to the GenBank as Ceratorhiza hydrophila isolate EG19 and the fungus ID is MK387081. The enzyme analyses showed its ability to produce protease and cellulase enzymes. According to the CSLI standard, the ethyl acetate extract of C. hydrophila showed intermediate antibacterial activity against Streptococcus pneumonia , Micrococcus luteus , and Staphylococcus aureus . Metabolic profiling has been carried out using 700 MHz NMR spectroscopy. Based on the 1 H and 1 H- 13 C heteronuclear single quantum coherence (HSQC) NMR data and NMR databases, 23 compounds have been identified. The identified metabolites include 31% amino acids, 9% sugars, 9% amines, 4% sugar alcohols, and 4% alkaloids. This is the first report for the metabolic characterization of C. hydrophila , which gave preliminary information about the fungus. It is expected that our findings not only will pave the way to other perspectives in enormous applications using C. hydrophila as a new promising source of antimicrobial agents and essential metabolites, but also it will be valuable in the classification and chemotaxonomy of the species.

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“…Alkyl betaines 2, or alkylamidopropylbetaines 3 are often introduced in shampoos as antistatic and viscosity-increasing agents (Figure 2). Hee Jung et al tested the antifungal activity of alkyl betaines against M. restricta KCTC 27527 [57]. Among the six betaine derivatives, lauryl betaine 2a exhibited high activity with MIC = 1.5-3 mg/mL.…”

Section: Inhibition Of the Cell Wall And Membrane Biosynthesismentioning

confidence: 99%

Anti-Malassezia Drug Candidates Based on Virulence Factors of Malassezia-Associated Diseases

Billamboz,

Jawhara

2023

Microorganisms

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Malassezia is a lipophilic unicellular fungus that is able, under specific conditions, to cause severe cutaneous and systemic diseases in predisposed subjects. This review is divided into two complementary parts. The first one discusses how virulence factors contribute to Malassezia pathogenesis that triggers skin diseases. These virulence factors include Malassezia cell wall resistance, lipases, phospholipases, acid sphingomyelinases, melanin, reactive oxygen species (ROS), indoles, hyphae formation, hydrophobicity, and biofilm formation. The second section describes active compounds directed specifically against identified virulence factors. Among the strategies for controlling Malassezia spread, this review discusses the development of aryl hydrocarbon receptor (AhR) antagonists, inhibition of secreted lipase, and fighting biofilms. Overall, this review offers an updated compilation of Malassezia species, including their virulence factors, potential therapeutic targets, and strategies for controlling their spread. It also provides an update on the most active compounds used to control Malassezia species.

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Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated FungusMalassezia restricta

Cited by 10 publications

References 41 publications

Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023

Bibliometric analysis of Traditional Chinese Medicine nanoparticles research from 2005 to 2023

Isolation, Characterization, and Metabolic Profiling of Ceratorhiza hydrophila from the Aquatic Plant Myriophyllum spicatum

Anti-Malassezia Drug Candidates Based on Virulence Factors of Malassezia-Associated Diseases

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