Antifungal Principles from Piper fulvescens

Abstract

Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans against five fungi strains were determined. Conocarpan showed the widest activity, whereas eupomatenoid 6 was the most active against dermatophytes.

Neolignanas e análise do óleo essencial das folhas de Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck

“…A presença destas substâncias em espécies da família Piperaceae já havia sido relatada anteriormente (Chauret et. al.,1996Freixa et. al., 2001.…”

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

“…The compounds (1), 21,29) (2) 7,21,23,29) and (3) 7,21,23,29,36) have been found in other Piper spp. In contrast, the flavonoid (4), was found only in P. solmsianum.…”

“…In a previous work Freixa and co-workers 23) showed that eupomatenoid-6 and conocarpan exerted considerable activity against some dermatophytes and yeasts. They suggested that the absence of the methoxyl group at position 3 on the phenyl-propenyl-benzofuran structure and the saturation of the carbons 7 and 8 could play important roles in antimicrobial activity.…”

“…10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others. 10) Among the different species of Piper growing in Brazil, Piper solmsianum (syn.…”

Antinociceptive properties of conocarpan and orientin obtained from Piper solmsianum C. DC. var. solmsianum (Piperaceae)

“…Conocarpan has been found in other species of Piper [22][23][24][25][26], but the flavonoid orientin is present only in P. solmsianum [14]. For the former compound, antibacterial [14,26], antifungal [13,27] and trypanocidal [28] activities have been described, whereas orientin has exhibited anxiolytic [29], vasorelaxant [30] and antioxidant [31] properties.…”