1984
DOI: 10.1002/jps.2600731250
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Antifungal properties of 2-n-Alkyn-1-ols

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Cited by 9 publications
(2 citation statements)
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“…The ease of drug penetration across biological membranes generally depends on the relative lipophilicity of the drug and the membrane. A parabolic relationship between the drug penetration rate and its lipophilicity has been observed for the cornea and other biological membranes (Mosher & Mikkelson 1979;Schoenwald & Huang 1983;Gershon et al 1984). Hence, the drug penetration usually increases with drug lipophilicity until a maximum is reached and then it ceases to increase or decreases with a further increase in drug lipophilicity.…”
mentioning
confidence: 94%
“…The ease of drug penetration across biological membranes generally depends on the relative lipophilicity of the drug and the membrane. A parabolic relationship between the drug penetration rate and its lipophilicity has been observed for the cornea and other biological membranes (Mosher & Mikkelson 1979;Schoenwald & Huang 1983;Gershon et al 1984). Hence, the drug penetration usually increases with drug lipophilicity until a maximum is reached and then it ceases to increase or decreases with a further increase in drug lipophilicity.…”
mentioning
confidence: 94%
“…A parabolic relationship between the drug penetration rate and its lipophilicity has been observed for the cornea and other biological membranes (Mosher & Mikkelson, 1979;Schoenwald & Huang, 1983;Gershon et al, 1984). Hence, although multiple pathways for drug transport across biological membranes have been proposed, the design of drugs with a suitable lipophilicity is of great importance to optimize drug penetration via the non-polar pathways.…”
Section: Introductionmentioning
confidence: 99%