Antifungal properties of chitosan salts in laboratory media

Abstract

Some aliphatic carboxylic acids were used to produce chitosan (CS) salts by reaction with CS, and their antifungal activity against three kinds of phytopathogens was estimated by hypha measurement in vitro. The fungicidal assessment showed that all of the CS salts had excellent activity against the tested fungi. Their inhibitory indices were 41. 15-64.15, 56.25-76.56, and 35.94-68.75% for Cladosporium cucumerinum (Ell.) et Arthur, Monilinia fructicola (Wint.) Honey, and Fusarium oxysporum sp. Cucumis sativus L., respectively, at 1000 lg/mL; these indices were higher than that of CS. It was confirmed that the amino groups' protonation was important for the antifungal activity of CS derivatives. The substituted groups with stronger electronegativity drew more electrons from the nitrogen atoms in the derivative molecules, which relatively strengthened the polycationic character of the CS derivatives. Therefore, the antifungal activity of the CS salts was improved.

Enhanced antifungal activities of four Zn(II) complexes based on uniconazole

“…The reason may be that the electronegativity of Cl ‐ in complex 3 is higher than that of Br ‐ in complex 4 . In addition, the electronegative group is beneficial to the biological activity . To thoroughly explore the reasons behind the increased biological activities of complexes 1 ‐ 4 , a computational investigation was conducted using DFT.…”

“…In addition, the electronegative group is beneficial to the biological activity. [40,43,44] To thoroughly explore the reasons behind the increased biological activities of complexes 1-4, a computational investigation was conducted using DFT.…”

The Molecular Structure and Conformational Dynamics of Chitosan Polymers: An Integrated Perspective from Experiments and Computational Simulations

“…Such progress has been more noticeable in the structural characterization of proteins and nucleic acids. Notwithstanding, carbohydrates are not too far behind despite difficulties in proton assignment of each atom due to the structural similarity of the monosaccharide units [19][20][21][22][23][24][25][26][27][28][29].…”

“…Besides being an abundant renewable resource, chitosan stands out due to some unique properties such as exceptional biocompatibility, biodegradability, non-toxicity and the easiness of production of chemically modified forms [14,25,26]. Furthermore, chitosan exhibits antimicrobial and antifungal activity [27][28][29][30]. These singular properties makes chitosan welll-suited for a wide range of biomedical applications such as drug delivery, platform for neural stem cell growth, tissue engineering (bone, cartilage, nerve, skin), immunoprophylaxis, gene therapy, wound healing and treatment of infections [31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

Chitosan Coating of Red Table Grapes and Fresh-Cut Honey Melons to Inhibit F usarium oxysporum Growth

“…; Ren et al . ). Many researchers have studied the antimicrobial action of chitosan on fungal or bacterial strains (Sebastien et al .…”