The present research work is based on two medicinal weeds: Alhagi maurorum and Tamarix aphylla (L.) mentioned in the 57 Ayat of Sura Al-Baqarah and 16 Ayat of Sura Saba in Holy Quran respectively. These plants were collected from Rajhanpur District, Punjab, Pakistan. The foremost purpose of this study is to document the knowledge of the ethnomedicinal significance of these plants in the light of Islam. An extensive and complete data was recorded. The comprehensive morphological character of these species was discussed. Botanical names, family, Quranic name, Arabic name, English name, Vernicular name, habit and habitat, distribution, parts used, medicinal uses are documented and references cited from Holy Quran, Ahadith.