Antifungal Susceptibility of Aspergillus Species Isolated from Patients Diagnosed with Invasive Aspergillosis

Atalay, Mustafa; Koç, Ayşe; SAV, Hafize; DEMİR, Gonca

doi:10.5222/ankem.2014.129

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…In a study conducted on patients with chronic obstructive pulmonary disease (COPD) diagnosed with IA in our hospital in 2013, researchers reported that VOR could be given as the initial treatment 12 . In a study conducted in our hospital in 2014, the MIC ranges of 26 Aspergillus isolates were found 0.004-2 μg/mL for AMB, 0.004-1 μg/mL for CAS, and 0.016-0.64 μg/mL for VOR 13 . These results are similar to our findings.…”

Section: Discussionmentioning

confidence: 89%

Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis

Sariguzel

Koç

Sağıroğlu

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to evaluate the demographic data, molecular epidemiology, and in vitro antifungal susceptibility results of patients with Aspergillus isolated from various clinical specimens. METHODS: A total of 44 Aspergillus strains were studied. The definition of invasive aspergillosis in patients was made according to European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) criteria. Strains were phenotypically and molecularly identified. Demographic characteristics of patients and genotypes of strains were evaluated. Phylogenetic analysis was done by the The Unweighted Pair-Group Method with Arithmetic Mean (UPGMA). Antifungal susceptibility of strains was determined according to The Clinical and Laboratory Standards Institute (CLSI)-M61-Ed2 and The European Committee on Antimicrobial Susceptibility Testing (EUCAST). RESULTS: A total of 11 patients were classified as proven and 33 as probable invasive aspergillosis. There was a statistically significant difference in age groups, subdisease, neutropenic, and receiving chemotherapy between groups. A total of 23 strains were identified as Aspergillus fumigatus, 12 as Aspergillus niger, 6 as Aspergillus flavus, and 3 as Aspergillus terreus. Phylogenetic analysis revealed five different genotypes. No statistical difference was found in the comparisons between patients groups and genotype groups. There was a statistically significant difference between genotype groups and voriconazole, posaconazole, and itraconazole Minimum Inhibition Concentration (MIC). CONCLUSION: Accurate identification of strains and antifungal susceptibility studies should be performed due to azole and amphotericin B resistance. Genotyping studies are important in infection control due to identifying sources of infection and transmission routes.

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Section: Discussionmentioning

confidence: 89%

Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis

Sariguzel

Koç

Sağıroğlu

et al. 2023

Rev. Assoc. Med. Bras.

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“…was detected in the sputum/bronchoscopy lavage/blood samples which could explain the infection was considered aspergillosis. [11][12][13] Diagnostic methods…”

Section: Definitionsmentioning

confidence: 99%

Which biomarkers help to distinguish between Candida and Aspergillus in patients with pulmonary infections?

Hazar¹

2018

South Clin Ist Euras

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This study was an evaluation of differences in the inflammatory markers of Creactive protein (CRP) level, the neutrophil-to-lymphocyte ratio (NLR), the platelet countto-mean platelet volume ratio (PLT/MPV), and the platelet-to-lymphocyte ratio (PLR) in patients with pulmonary candidiasis and pulmonary aspergillosis. Methods: A retrospective, cross-sectional study was performed with the data of patients who were diagnosed with pulmonary candidiasis and pulmonary aspergillosis between 2016 and 2017 according to the records of the hospital information system. The results and date of hemograms, the biochemistry values, and C-reactive protein (CRP) levels were recorded. The NLR, PLT/MPV, and PLR were calculated. The documented parameters of the study groups were compared and analyzed. Results: There were 44 patients (29 men) (candidiasis, n=19; aspergillosis, n=25), with a median age of 65 years. In both groups, the incidence of chronic obstructive pulmonary disease, level of CRP, and the NLR, PLR, MPV, and PLT/MPV were statistically similar. At discharge, the CRP, PLR, NLR, and PLT values were still similar in the 2 groups; however, the MPV was significantly lower in the pulmonary aspergillosis group when compared with the pulmonary candidiasis group (7.3 vs 8.4; p=0029). Conclusion: Most biomarkers were similar in the pulmonary aspergillosis and the candidiasis groups; however, a PLT elevation and an MPV decrease were significant in the diagnosis of aspergillus. Similar findings in prospective, multicenter studies performed with patients who are suspected of having a fungal lung infection will add to the ultimate determination of the value to be given to PLT and MPV biomarkers in the initiation of empirical treatment.

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“…In recent years, an increase in the incidence of Candida infections has been observed in parallel with the developments in the field of diagnosis and treatment, with the increase in the number of patients receiving immunosuppressive therapy, the use of large surgical interventions and broad-spectrum antibiotics, and the patients with poor general condition followed in intensive care units (ICUs) [5]. As the patient population at risk increases, especially in ICU, infections with Candida species are becoming increasingly important [6]. Although C. albicans is the most common cause of candidemia, it has been observed that the rate of Candida species other than albicans has increased according to recent studies.…”

Section: Introductionmentioning

confidence: 99%

Distribution of clinical Candida species and their susceptibility to antifungal agents

Tümer

Bayraktar

Öztürk

2021

Reviews in Medical Microbiology

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Background: The incidence of fungal infections, especially by Candida species, has increased in recent years. This study was designed to isolate and identify Candida species from various clinical samples, and to examine their susceptibility to antifungal agents.Methods: A total of 175 Candida species were isolated from different clinical samples, and were identified using germ tube test, Cornmeal agar, and API C 20 AUX and VITEK 2 Compact Systems. Antifungal susceptibility of these isolates was determined using ATB Fungus 3 strip and VITEK 2 antifungal susceptibility cards. The results of these two methods were comparatively assessed.Results: A total of 175 Candida strains were isolated from 114 (65.1%) urine, 42 (24%) blood, eight (4.6%) sputum, seven (4%) endotracheal, and four (2.3%) wound samples. Of isolated Candida species, 102 (58.2%) were Candida albicans, 31 (17.6%) Candida tropicalis, 17 (9.6%) Candida parapsilosis, 13 (7.4%) Candida glabrata, three (1.8%) Candida kefyr, three (1.8%) Candida krusei, two (1.2%) Candida lusitaniae, and one (0.6%) Candida famata. By VITEK 2 antifungal susceptibility cards, the overall resistance rates were 0.6% to each of amphotericin B and 5-flucytosine, and 1.8% to fluconazole. In ATB Fungus 3 strip, the resistance (1.8%) was observed only to fulconazole. All isolates were uniformly susceptible to voriconazole in both methods. Conclusion:Valuable information and data on distribution and susceptibility of Candida strains were obtained. These data may be valuable from epidemiological point of view as well as for proper and optimal therapy of Candida infections in our region (S ¸anlıurfa, Turkey).

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Antifungal Susceptibility of Aspergillus Species Isolated from Patients Diagnosed with Invasive Aspergillosis

Cited by 3 publications

References 16 publications

Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis

Molecular epidemiology and antifungal susceptibilities of Aspergillus species isolated from patients with invasive aspergillosis

Which biomarkers help to distinguish between Candida and Aspergillus in patients with pulmonary infections?

Distribution of clinical Candida species and their susceptibility to antifungal agents

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