“Antifungal Susceptibility Pattern of Oropharyngeal Candidiasis in Cancer Patients”

Abstract

Introduction: Fungal infections like oral candidiasis is prevalent in cancer patients as their immune systems were compromised.Material and Methods: 377 cancer patients who were clinically diagnosed with oropharyngeal candidiasis were included in the study. Isolation and identification of Candida species was based on standard microbiological procedures. CLSI (2021) recommendations were followed when determining antifungal susceptibility.Results: Among the total 377 cases included, the highest number of instances was reported in those aged 41 to 50 years (30.23%). Candida albicans (21.98%) was the most frequent followed by Candida tropicalis (18.84%), Candida prapsilosis (17.80%). Monomicrobial growth was observed in 77.63% patients whereas polymicrobial growth was observed in 22.36% patients. Candida albicans (24.59%) and Candida tropicalis (20.49%) were the most frequent isolates among patients who underwent chemotherapy while Candida albicans (40%) and Candida Parapsilosis (26.66%) were the most frequent isolates among patients undergoing radiotherapy. Miconazole was found to be more susceptible than Fluconazole, Itraconazole, Clotriconazole among the antifungals.Conclusion: Due to the risk of a systemic infection, it is important to recognise candidiasis as soon as possible for the clinical management of seriously unwell cancer patients. It may also aid the clinician in selecting antifungals for empirical treatment.

Association of MT1A rs11640851, rs8052394 and rs11076161 polymorphisms with the risk of developing breast cancer: a haplotype-based case-control study and in silico analysis

“…According to the latest data from the American Cancer Society (ACS), in 2023, an estimated 297,790 new cases of BC will be diagnosed (31% of all new cases) and 43,170 women will die from the disease (15% of all cancer-related deaths) in the United States (Siegel, Miller, Wagle, & Jemal, 2023). Breast cancer is a heterogeneous condition resulting from the complex interplay of multiple genetic, environmental, and lifestyle factors (Singh & kumar Sain, 2023;Swaminathan, Saravanamurali, & Yadav, 2023). Despite considerable progress towards understanding breast carcinogenesis in recent decades, there are still so many unanswered questions regarding BC etiopathogenesis (Feng et al, 2018;Park et al, 2022).…”