Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Anti‐anaphylactic Effects of Sodium Cromoglycate and Aminophylline

Andersson, Paul

doi:10.1111/j.1476-5381.1980.tb07036.x

Cited by 55 publications

(30 citation statements)

References 24 publications

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“…IgE and allergic hyperreactivity The method used for generation of antiserum in this study has been reported to evoke IgE formation in this species (12). To ascertain whether IgE-mediated responses contributed to acute allergic bronchospasm or allergic hyperreactivity, serum was heated for 4 hr at 56'C, prior to intravenous injection.…”

Section: Airway Obstruction and Airway Hyperreactivitymentioning

confidence: 99%

Allergic Bronchospasm and Airway Hyperreactivity in the Guinea Pig

Hoshiko

Morley

1993

Japanese Journal of Pharmacology

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ABSTRACT-In passively sensitized guinea pigs, slow infusion of an amount of ovalbumin insufficient to evoke airway obstruction induces hyperreactivity of the airways. A wide range of changed responsivity was observed for different test spasmogens, with leukotriene C4 > histamine > prostaglandin Fl, > bradykinin > leukotriene E4> serotonin > acetylcholine. Injection of ovalbumin as a bolus produced pronounced airway obstruction without hyperreactivity. Airway obstruction due to vascular engorgement (dextran infusion) or edema (histamine infusion) did not result in hyperreactivity. Infusion of PAF induced pronounced airway obstruction together with hyperreactivity, but with a rank order of histamine>leukotriene C4> serotonin > bradykinin > leukotriene E4 > acetylcholine. It can be concluded that allergic airway hyper reactivity in the guinea pig is spasmogen-selective and largely independent of airway obstruction. These observations question the presumption of non-selective hyperreactivity in allergic asthma and cast doubt upon the proposal that airway hyperreactivity is secondary to airway obstruction.

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Section: Airway Obstruction and Airway Hyperreactivitymentioning

confidence: 99%

Allergic Bronchospasm and Airway Hyperreactivity in the Guinea Pig

Hoshiko

Morley

1993

Japanese Journal of Pharmacology

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“…Thus higher provocation doses are needed to obtain an effect and much more histamine is released after anaphylactic challenge in guinea-pigs sensitized to produce a mixture of IgG and IgE antibodies compared with those sensitized to produce only IgG antibodies (Andersson, 1980a; 0007-1188/82/100301-07 $01.00 Andersson & Bergstrand, 1981). Furthermore, disodium cromoglycate (SCG) and glucocorticoids do not prevent IgG-mediated bronchial anaphylaxis (Andersson, 1980b; Andersson & Bergstrand, 1981; Andersson & Brattsand, 1982).…”

Section: Introductionmentioning

confidence: 99%

Effects of Inhibitors of Anaphylactic Mediators in Two Models of Bronchial Anaphylaxis in Anaesthetized Guinea‐pigs

Andersson

1982

British J Pharmacology

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“…In an earlier investigation it was observed that a bronchial anaphylactic reaction which, at least partly, is mediated by IgE-like antibodies, is greatly inhibited by acute treatment with SCG, whereas an IgG-mediated reaction is not. Theophylline inhibits both IgG-and IgE-mediated reactions (Andersson, 1980b). However, long-term treatment with the investigated compounds would possibly be more relevant to the clinical situation.…”

Section: Introductionmentioning

confidence: 99%

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

Andersson

Bergstrand

1981

British J Pharmacology

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The effects of long‐term treatment with sodium cromoglycate (SCG) and aminophylline on antigen‐induced bronchoconstriction have been studied in guinea‐pigs actively sensitized according to two different regimens (one producing IgE‐ and IgG‐like antibodies and the other producing exclusively IgG‐like antibodies). Treatment for three weeks with SCG (10 mg/kg) and aminophylline (10,30 or 60 mg/kg) led to a decreased bronchial response capacity which persisted even three days after treatment ceased. In this respect SCG was effective only in guinea‐pigs sensitized to produce at least partly IgE‐like antibodies; aminophylline was effective in guinea‐pigs sensitized to produce both IgE and/or IgG antibodies. The results in vivo with SCG were reflected in vitro by a reduced capacity of chopped lung tissue to release histamine at antigen challenge; lungs from animals treated with aminophylline did not show reduced histamine releasing capacity. Acute treatment with atropine was shown to reduce significantly the antigen‐induced bronchial contraction in guinea‐pigs sensitized to produce both IgE‐ and IgG‐antibodies. No effect of atropine was seen on an IgG‐mediated anaphylaxis. Increased reactivity to methacholine but not to histamine was seen in guinea‐pigs sensitized to produce both IgG‐ and IgE‐antibodies. Long‐term treatment with SCG did not affect this hyperreactivity to methacholine. Decreased reactivity to isoprenaline was found in isolated tracheae taken from guinea‐pigs sensitized to produce both IgE‐ and IgG‐like antibodies compared to unsensitized guinea‐pigs. Long‐term treatment with SCG, but not with aminophylline, reversed this decreased reactivity.

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Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Anti‐anaphylactic Effects of Sodium Cromoglycate and Aminophylline

Cited by 55 publications

References 24 publications

Allergic Bronchospasm and Airway Hyperreactivity in the Guinea Pig

Allergic Bronchospasm and Airway Hyperreactivity in the Guinea Pig

Effects of Inhibitors of Anaphylactic Mediators in Two Models of Bronchial Anaphylaxis in Anaesthetized Guinea‐pigs

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

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