Antigen-induced selective recruitment of circulating lymphocytes

Sprent, Jonathan; Miller, J. F. A. P.; Gf, Mitchell

doi:10.1016/0008-8749(71)90036-0

Cited by 206 publications

(84 citation statements)

References 13 publications

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“…The migratory behaviour of resident CD4 þ T cells described herein differs from the well-known antigen-specific sequestration of activated T cells in LNs carrying that antigen 22,23 . In these cases, responding T cells have been reported to re-enter the circulation 3 days after antigen recognition.…”

Section: Articlementioning

confidence: 66%

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

et al. 2014

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Effector and memory CD4 þ T cells acquire distinct migratory properties depending on the type and location of the immune responses. Due to the highly dynamic nature of T cell circulation, the comprehensive analysis of these migratory routes requires dedicated experimental approaches. Here, we analyse the migration of effector/memory CD4 þ T cells by long-term in vivo cell tracking. We identify a resident population of antigen-experienced CD4 þ T cells that resides in lymph nodes and Peyer's patches without circulation or proliferation. Resident CD4 þ T cells constitute up to 50% of all effector/memory cells, including, but not limited to, follicular helper T cells. Furthermore, these non-circulating T cells possess a distinct T cell receptor repertoire and accumulate in Peyer's patches after continuous oral antigen exposure. Our results provide the first direct evidence for a resident population of effector/memory CD4 þ T cells that is retained in lymphoid tissues.

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Section: Articlementioning

confidence: 66%

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

et al. 2014

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“…Seminal studies showed that Ag-specific lymphocytes are selectively recruited from circulation to secondary lymphoid tissues as early as 24 h following immunization (11). Similarly, immunization with soluble protein results in the disappearance of all Ag-specific CD8 T cells from peripheral blood within 24 h (Ref.…”

Section: Antiviral Cd8 T Cells Are Not Simultaneously Recruited From mentioning

confidence: 99%

Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program

D’Souza

Hedrick

2006

The Journal of Immunology

115

104

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Factors that influence T cell responses, such as Ag load, APCs, costimulatory molecules, and cytokines, dramatically change during the course of an immune response. We observed that antiviral CD8 T cells were not recruited from circulation simultaneously, but over a period of 3–4 days. Consequently, locally resident T cells and those that entered secondary lymphoid tissue later were primed in very different environments. The cells recruited later in the response were imprinted with a unique differentiation program, such that their magnitude of proliferation was reduced and their kinetics of expansion was delayed. In addition, we found that the “latecomer” CD8 T cells displayed a unique surface phenotype indicative of reduced stimulation but were not preferentially recruited into the surviving pool of memory cells. This finding demonstrates that the timing of recruitment of individual T cell clones determines the population dynamics of the subsequent immune response.

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“…Using these criteria, it has been demonstrated that priming for a 2 ° response to sheep erythrocytes (SRBC) in mice occurs during a 4-5 day period after immunization (2,3). For other antigens, the development of memory may be a longer process (1,4) and the long-term persistence of antigen may be an important requirement, as it may also be for the maintenance of memory (5).…”

Section: (From the Department Of Zoology Edinburgh University Edinbmentioning

confidence: 99%

Characteristics of Immunological Memory in Mice

Black

Inchley

1974

The Journal of Experimental Medicine

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The kinetics of the generation of primed IgM and IgG antibody-forming cell precursors, and of helper T-cell populations, were analyzed in mice whose primary responses to high and low doses of SRBC were arrested at intervals by the immunosuppressive agents cyclophosphamide monohydrate and specific antibody. The extent to which immunological memory was established in these animals before blockade of the primary response was assessed by the hemolytic plaque assay following challenge 12 wk after priming. The presence of IgG B-memory cells and T-memory cells in suppressed mice was further investigated by the transfer into these animals of syngeneic SRBC-stimulated thymocytes or anti-θ-treated spleen cells. It was found that the progenitors of secondary IgM-synthesizing cells were primed almost immediately after injection of antigen, and that early blockade of the primary response resulted in a raised IgM response after challenge. On the other hand, priming for a secondary IgG response took at least 4 days, and was dose-dependent, although helper T populations for a secondary IgG response appeared 3 days after antigen injection. It appeared that both IgM and IgG memory cells may be considered as Y cells in terms of the X-Y-Z scheme of lymphocyte activation, but that the two populations are generated at different times after exposure to antigen. The size of either Y-cell population at any given time is dependent upon the amount of antigen available to provoke differentiation to antibody-forming Z cells, and the IgM Y-cell population in particular is likely to be depleted during the course of a normal 1° response. When IgM Y cells were maintained for long periods as a result of immunosuppression, their secondary antibody response was independent of the primed T cells necessary for a secondary IgG response.

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Antigen-induced selective recruitment of circulating lymphocytes

Cited by 206 publications

References 13 publications

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program

Characteristics of Immunological Memory in Mice

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