Antigen Levels of Dermatophagoides Mites (Acari: Pyroglyphidae) in Dust Samples Collected in Homes of Allergic Patients

Pediatric Allergy Immunology

et al. 2010

Saito K, Yokoyama T, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y. Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3–4 months: The Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 2010: 21: 38–46. © 2009 John Wiley & Sons A/S Interest has increased in the possibility that maternal dietary intake during pregnancy might influence the development of allergic disorders in children. The present prospective study examined the association of maternal intake of selected foods high in fatty acids and specific types of fatty acids during pregnancy with the risk of suspected atopic eczema among Japanese infants aged 3–4 months. Subjects were 771 mother–child pairs. Information on maternal dietary intake during pregnancy was assessed with a validated self‐administered diet history questionnaire. The term ‘suspected atopic eczema’ was used to define an outcome based on results of our questionnaire completed by mothers 3–4 months postpartum. The risk of suspected atopic eczema was 8.4% (n = 65). Higher maternal intake of meat during pregnancy was significantly associated with an increased risk of suspected atopic eczema in the offspring: the multivariate odds ratio (OR) for the highest vs. lowest quartile was 2.59 [95% confidence interval (CI): 1.15–6.17, p for trend = 0.01]. The positive association was strengthened when the definition of the outcome was confined to a definite physician’s diagnosis of atopic eczema (n = 35): the multivariate OR between extreme quartiles was 3.53 (95% CI: 1.19–12.23, p for trend = 0.02). No material exposure–response relationships were observed between maternal intake of eggs, dairy products, fish, total fat, saturated fatty acids, monounsaturated fatty acids, n‐3 polyunsaturated fatty acids, α‐linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n‐6 polyunsaturated fatty acids, linoleic acid, arachidonic acid and cholesterol and the ratio of n‐3 to n‐6 polyunsaturated fatty acid consumption and the risk of suspected atopic eczema. Higher maternal meat intake may increase the risk of infantile atopic eczema, whereas we found no evidence that maternal intake of fish and n‐3 polyunsaturated fatty acids are preventive against infantile atopic eczema.

Section: Methodsmentioning

confidence: 99%

Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3–4 months: The Osaka Maternal and Child Health Study

Saito

Yokoyama²,

Pediatric Allergy Immunology

et al. 2010

“…Antigen levels from extracts of fine dust fractions were measured by a double‐antibody sandwich enzyme‐linked immunosorbent assay using a soluble antigen prepared from whole Dermatophagoides farinae mite bodies as a reference standard and were expressed as antigen equivalent in μ g/m 2 of surface area (Mitey checker®, Shinto Fine Co., Ltd, Osaka, Japan; 9, 10). Antigen levels were semiquantitatively classified with scores of − (<2 μ g/m 2 ), ± (5 μ g/m 2 ), + (10–15 μ g/m 2 ), and ++ (>35 μ g/m 2 ).…”

Section: Methodsmentioning

confidence: 99%

Home environment and suspected atopic eczema in Japanese infants: The Osaka Maternal and Child Health Study

Pediatric Allergy Immunology

Ohya

Tanaka

et al. 2007

Atopic eczema is most commonly diagnosed in children under the age of 5 yr. Environmental factors during pregnancy or in early life may confer risk for childhood atopic eczema. The present prospective study examined the relationship of the perinatal home environment and the risk of suspected atopic eczema among Japanese infants under the age of 1. Study subjects were 865 parent-child pairs. The term 'suspected atopic eczema' was used to define an outcome based on our questionnaire at 2-9 months postpartum. Adjustment was made for maternal age, gestation, family income, maternal and paternal education, maternal and paternal history of asthma, atopic eczema, and allergic rhinitis, time of delivery before the second survey, baby's older siblings, baby's sex, and baby's birth weight. A high mite allergen level from maternal bedclothes and mold in the kitchen during pregnancy were significantly associated with an increased risk of suspected atopic eczema. Frequent vacuuming practices during pregnancy and giving the infant a bath or shower at least once a day were significantly inversely related to the risk of suspected atopic eczema. Maternal smoking, maternal use of a synthetic duvet and pillow, carpet use in the living room and maternal bedroom, indoor domestic pets, no ducted heating appliance, and gas use for cooking during pregnancy and household smoking in the same room as the infant, infant's synthetic duvet, carpet use in the infant's room, or vacuuming the infant's room were not related to the risk of suspected atopic eczema. High house dust mite allergen levels and mold in the kitchen during pregnancy may increase the risk of infantile atopic eczema, whereas frequent vacuuming practices during pregnancy and giving the infant a bath or shower at least once a day may protect against infantile atopic eczema.

“…Antigen levels from extracts of fine dust fractions were measured by a double-antibody sandwich enzyme-linked immunosorbent assay using a soluble antigen prepared from whole Dermatophagoides farinae mite bodies as a reference standard and were expressed as antigen equivalent in µg/m 2 of surface area (Mitey checker ® , Shinto Fine Co., Ltd., Osaka, Japan) [17, 18]. Antigen levels were semiquantitatively classified with scores of – (<2 µg/m 2 ), ± (5 µg/m 2 ), + (10– 15 µg/m 2 ) and ++ (>35 µg/m 2 ).…”

Section: Methodsmentioning

confidence: 99%

Relationship between Active and Passive Smoking and Total Serum IgE Levels in Japanese Women: Baseline Data from the Osaka Maternal and Child Health Study

Int Arch Allergy Immunol

Miyamoto²,

Ohya³

et al. 2004

Background: Many studies have shown that cigarette smoking is associated with elevated concentrations of total serum IgE. Few studies, however, have examined total IgE in relation to passive smoking exposure, especially in adults. This cross-sectional study investigated the association of active and passive smoking exposure with levels of total serum IgE in Japan. Methods: Study subjects were 981 pregnant women in Osaka. Total IgE levels were measured using UniCAP 1000 and were defined as elevated if they exceeded 170 ml/UI. Age, gestation, parity, family history of asthma, atopic eczema and allergic rhinitis, indoor domestic pets, family income, education and the mite allergen level in house dust were selected as potential confounding factors. Results: Current smoking of at least 15 cigarettes a day and 8.0 or more pack-years of smoking were independently related to an increased prevalence of elevated total serum IgE (adjusted odds ratios 3.40 and 2.51, 95% confidence intervals 2.12–5.47 and 1.55–4.06, respectively), and both cigarette smoking status and pack-years of smoking were significantly positively associated with total serum IgE levels, especially in subjects with a positive familial allergic history. There was no measurable association of exposure to environmental tobacco smoke (ETS) at home or at work with total serum IgE concentrations among those who had never smoked. Conclusions: Our results corroborate a positive relationship between active smoking and total serum IgE levels; however, this study failed to substantiate a positive association of ETS exposure with total IgE. Investigations with more precise and detailed exposure measurements are warranted.