Antigen presentation by guinea pig alveolar macrophages.

Lipscomb, Mary F.; Toews, Galen B.; Lyons, C. Rick; Uhr, J W

doi:10.4049/jimmunol.126.1.286

Cited by 71 publications

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“…For instance, upon microbial invasion, AMs can produce a variety of inflammatory cytokines and chemo-attractive mediators to recruit other immune cells (such as neutrophils and monocytes), contributing to the development of pulmonary inflammatory responses [10]. AMs can also act as accessory cells by presenting antigens to T lymphocytes to facilitate adaptive immune responses [11,12]. Finally, upon pathogen clearance, AMs play a critical role in the repair and remodeling of connective tissue in the lung parenchyma [13].…”

Section: Introductionmentioning

confidence: 99%

Glutamine Metabolism Is Required for Alveolar Macrophage Proliferation

Wang,

Zhu,

Zhang

et al. 2024

Journal of Respiratory Biology and Translational Medicine

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Alveolar macrophages (AMs) are critical for normal lung homeostasis, surfactant metabolism, and host defense against various respiratory pathogens. Despite being terminally differentiated cells, AMs are able to proliferate and self-renew to maintain their compartment without the input of the hematopoietic system in the adulthood during homeostasis. However, the molecular and metabolic mechanisms modulating AM proliferative responses are still incompletely understood. Here we have investigated the metabolic regulation of AM proliferation and self-renewal. Inhibition of glucose uptake or fatty acid oxidation did not significantly impact AM proliferation. Rather, inhibition of the glutamine uptake and/or glutaminase activity impaired AM mitochondrial respiration and cellular proliferation in vitro and in vivo in response to growth factor stimulation. Furthermore, mice with a genetic deletion of glutaminase in macrophages showed decreased proliferation. Our data indicate that glutamine is a critical substrate for fueling mitochondrial metabolism that is required for AM proliferation. Overall, our study is expected to shed light on the AM maintenance and repopulation by glutamine during homeostasis and following acute respiratory viral infection.

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Section: Introductionmentioning

confidence: 99%

Glutamine Metabolism Is Required for Alveolar Macrophage Proliferation

Wang,

Zhu,

Zhang

et al. 2024

Journal of Respiratory Biology and Translational Medicine

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Gut‐ and bronchus‐associated lymphoid tissue

1984

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Bronchus-associated and gut-associated lymphoid tissues (BALT and GALT) have both functional and morphologic similarities and are involved in seeding lung, gut, and other mucosal sites with predominantly IgA-containing B cells. Both types of lymphoid tissue are engaged in the regulation and the controlled amplification of immune responses, which vary from positive mucosal responses in both mucosae and peripheral tissues to local mucosal responses and systemic tolerance. Their further involvement in provision of cells destined to reside in the epithelial compartment of the body appears likely but requires further investigation. Their role in the provision of precursors of mucosal mast cells must also be explored further, but some participation in this event appears likely. The mucosa-associated lymphoid tissue (MALT) system appears to be integrated with the systemic immune system but may be considered as separate from it in several functional ways.

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The role of macrophages and immunocytes in the pathogenesis of pulmonary diseases due to mineral dusts

Pernis

Vigliani

1982

American J Industrial Med

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There is considerable evidence of generalized stimulation of the immune system in pulmonary dust diseases. This stimulation involves both the T- and the B-arms of the immune system. A reasonable explanation of this immune stimulation resides in an effect of the mineral dusts on the macrophages. This effect is likely to be mediated by the production of interleukin-1. Since the same substance also stimulates fibroblasts, a unified view of the pathogenesis of pulmonary dust diseases is now possible.

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Antigen presentation by guinea pig alveolar macrophages.

Cited by 71 publications

References 0 publications

Glutamine Metabolism Is Required for Alveolar Macrophage Proliferation

Glutamine Metabolism Is Required for Alveolar Macrophage Proliferation

Gut‐ and bronchus‐associated lymphoid tissue

The role of macrophages and immunocytes in the pathogenesis of pulmonary diseases due to mineral dusts

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