1984
DOI: 10.4049/jimmunol.133.3.1202
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Antigen presentation by the BCL1 murine B cell line: in vitro stimulation by LPS.

Abstract: We examined the antigen-presenting capacity of BCL1 tumor cells, which are capable of differentiating in vitro with respect to immunoglobulin synthesis/secretion under the influence of LPS. In vivo passaged BCL1 cells depleted of host cell contamination either by positive selection employing panning with anti-lambda reagents, or by elimination of latex-ingesting adherent cells, are capable of MHC-restricted antigen presentation to a GAT-immune T cell line. The BCL1 cells act as antigen-presenting cells when fr… Show more

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Cited by 7 publications
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“…Cell lines expressing I-A d (e.g., A20, K46R, 2PK3, BCL 1 B cell line, or PU5, WEHI-265 monocytic cell line) can be employed as antigen-presenting cells (APC) for activating the CDC35 or D1.6 T H cells (Walker et al, 1982;Harris et al, 1984;Zuckerman et al, 1988;Spencer et al, 1993). Use of cell lines for the APC source provides two advantages: first, mice do not have to be sacrificed, and, second, homogeneous preparations of B cells versus monocytic lines can be compared.…”
Section: Supplement 24mentioning
confidence: 99%
“…Cell lines expressing I-A d (e.g., A20, K46R, 2PK3, BCL 1 B cell line, or PU5, WEHI-265 monocytic cell line) can be employed as antigen-presenting cells (APC) for activating the CDC35 or D1.6 T H cells (Walker et al, 1982;Harris et al, 1984;Zuckerman et al, 1988;Spencer et al, 1993). Use of cell lines for the APC source provides two advantages: first, mice do not have to be sacrificed, and, second, homogeneous preparations of B cells versus monocytic lines can be compared.…”
Section: Supplement 24mentioning
confidence: 99%