Antigen-Presenting Cells in Human Endometrium During the Menstrual Cycle Compared to Early Pregnancy

Rieger, Lorenz; Hönig, Arnd; Sütterlin, Marc; Kapp, Michaela; Dietl, Johannes; Ruck, Peter; Kämmerer, Ulrike

doi:10.1016/j.jsgi.2004.05.007

Cited by 105 publications

(83 citation statements)

References 23 publications

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“…We can also hypothesize that the increase in the expression of NKp30 may be one of the pathways that results in the significant increase of mature DC seen in the late-secretory stage of the menstrual cycle [26][27][28][29]. These data also suggest a mechanism for how the epithelium may initiate the process of establishing immune tolerance in the decidua, at the time of trophoblast invasion.…”

Section: Discussionmentioning

confidence: 90%

“…Endometrial epithelium has been shown to have antigen-presenting ability, a capability that is under hormonal control [22][23][24]. Recent studies have shown that the numbers of mature and immature DC significantly increase in endometrium during the latesecretory phase and early pregnancy [25][26][27][28][29]. These observations raise the possibility that NKp30 may have a role in promoting immune tolerance while maintaining immune surveillance in the endometrium during embryo implantation.…”

Section: Discussionmentioning

confidence: 99%

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Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium

Ponnampalam¹,

Gargett²,

Rogers³

2007

Eur J Immunol

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This study reports the discovery and steroid hormonal regulation of a novel glycosylated form of NKp30 in human endometrial epithelium. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. The aims of the present study were to fully characterize NKp30 mRNA and protein in human endometrium during the menstrual cycle, and to investigate the hormonal regulation of NKp30. NKp30 mRNA was significantly up-regulated in fresh tissues during late secretory phase of the menstrual cycle. Interestingly, NKp30 mRNA was also present in clonally derived endometrial epithelial cells (CEE) in comparable amounts to fresh tissue. NKp30 protein was predominantly found in the endometrial glands and luminal epithelia of the secretory phase endometrium. Western blotting and de-glycosylation studies show that a novel glycosylated form of NKp30 is present in endometrial epithelium and that it can dimerize. Further phenotyping of CEE by flow cytometry revealed that they are CK8 + CD49f + NKp30 + CD45 -CD56 -. The data also show that transcription and translation of the novel form of NKp30 can be induced by progesterone treatment after 48 h in endometrial explants in vitro. This is the first report to show the presence of both NKp30 mRNA and a novel glycosylated form of NKp30 protein in endometrial epithelial cells.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium

Ponnampalam¹,

Gargett²,

Rogers³

2007

Eur J Immunol

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“…20,64 mDCs are further subdivided into a predominant population of immature DC-SIGN 1 cells, which increase during pregnancy development, 18 and a smaller population of mature CD83-expressing cells. 5,17 These observations suggest that full decidualization in response to the implantation and placentation processes is associated with a decline in CD83 1 cells and an increase in DC-SIGN 1 DCs. After fetal antigen uptake, DC-SIGN 1 cells differentiate into mature CD83 1 cells, migrate to the secondary lymphoid organs and stimulate the resident T-cell population.…”

Section: Human Dcsmentioning

confidence: 93%

“…4 iDCs existing in the human non-pregnant endometrium are characterized by DC-SIGN (DC-specific intercellular adhesion molecule 3-grabbing nonintegrin) expression, and represent approximately 5%-10% of all hematopoietic cells. 5,17 The presence of these immature DC-SIGN 1 cells in the endometrium, and their maturation to mDC CD83 1 cells upon exposure to antigens or inflammatory cytokines during the menstrual cycle, suggest that these are likely involved in the uterine defense against pathogens. 17 Following conception, first trimester human decidual tissue contains mainly DCs of myeloid origin, but not plasmacytoid DCs.…”

Section: Human Dcsmentioning

confidence: 99%

“…5,17 The presence of these immature DC-SIGN 1 cells in the endometrium, and their maturation to mDC CD83 1 cells upon exposure to antigens or inflammatory cytokines during the menstrual cycle, suggest that these are likely involved in the uterine defense against pathogens. 17 Following conception, first trimester human decidual tissue contains mainly DCs of myeloid origin, but not plasmacytoid DCs. 20,64 mDCs are further subdivided into a predominant population of immature DC-SIGN 1 cells, which increase during pregnancy development, 18 and a smaller population of mature CD83-expressing cells.…”

Section: Human Dcsmentioning

confidence: 99%

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Liaison between natural killer cells and dendritic cells in human gestation

et al. 2014

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A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN 1 dendritic cells (DCs) and CD56 1 natural killer (NK) cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.

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The roles of the immune system in Women's reproduction: Evolutionary constraints and life history trade‐offs

Abrams

Miller

2011

American J Phys Anthropol

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Life history theory posits that, as long as survival is assured, finite resources are available for reproduction, maintenance, and growth/storage. To maximize lifetime reproductive success, resources are subject to trade-offs both within individuals and between current and future investment. For women, reproducing is costly and time-consuming; the bulk of available resources must be allocated to reproduction at the expense of more flexible systems like immune function. When reproducing women contract infectious diseases, the resources required for immune activation can fundamentally shift the patterns of resource allocation. Adding to the complexity of the reproductive-immune trade-offs in women are the pleiotropic effects of many immune factors, which were modified to serve key roles in mammalian reproduction. In this review, we explore the complex intersections between immune function and female reproduction to situate proximate immunological processes within a life history framework. After a brief overview of the immune system, we discuss some important physiological roles of immune factors in women's reproduction and the conflicts that may arise when these factors must play dual roles. We then discuss the influence of reproductive-immune trade-offs on the patterning of lifetime reproductive success: (1) the effect of immune activation/infectious disease on the timing of life history events; (2) the role of the immune system, immune activation, and infectious disease on resource allocation within individual reproductive events, particularly pregnancy; and (3) the role of the immune system in shaping the offspring's patterns of future life history trade-offs. We close with a discussion of future directions in reproductive immunology for anthropologists.

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Antigen-Presenting Cells in Human Endometrium During the Menstrual Cycle Compared to Early Pregnancy

Cited by 105 publications

References 23 publications

Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium

Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium

Liaison between natural killer cells and dendritic cells in human gestation

The roles of the immune system in Women's reproduction: Evolutionary constraints and life history trade‐offs

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