Antigen‐Reactive Cell Opsonization (ARCO) and its Role in Antibody‐Mediated Immune Suppression

Effects of the interferon-inducer ABPP on colon cancer in rats; importance of tumor load and tumor site

“…Kupffer cells may play an important role since they may have rapidly degraded tumor-associated antigens as seen with allogeneic organ transplants [18] or have opsonized antigen reactive cells [7]. Enhancement of Kupffer cell activity in rats, caused by tumor challenge, has been reported by Antikatzides and Sabe [1], reaching a peak level after 6 days.…”

Isolation of Patient‐Related Antigens from Allergen Extracts by Means of Protein A‐Sepharose‐Patient IgG1,2,4 Bio‐Affinity Chromatography

“…A possible mechanism on the cellular level whereby the immune complexes could elicit a tolerogenic signal could be through antigenreactive cell opsonization (ARGO) (10). According to this mechanism for antibody-mediated immune response the antigen reactive cells (B and/or T cells) are opsonized by antigen-antibody complexes (or by anti-idiotype antibody) and are subsequently destroyed by macrophages.…”

Cellular mechanisms: Induction of heart allograft survival in rats by 15-deoxyspergualin

“…The results show that the MLR in LEW spleen cells to donor party (ACI) and third party (Wistar) stimulator spleen cells were inhibited in a cell-dose-dependent manner. As various mechanisms of graft survival, such as the modulation of graft antigen expression [6,14], depletion of clonally active cells following immunosuppression and exposure to the graft [7,8], antigen/antibody blockade of effector cells [15,16], activation of suppressor cells [3,13],and production of suppressor humoral factor(s), have been postulated. Our results strongly suggest that DSG may fail to affect suppressor cells, and these cells may progressively develop and play a partial role in continuing allograft survival states.…”