Antigen-specific IgE in Sinus Mucosa of Allergic Fungal Rhinosinusitis Patients

Wise, Sarah K.; Ahn, Chadwick N; Lathers, Deanne; Mulligan, R. M.; Schlosser, Rodney J.

doi:10.2500/ajr.2008.22.3227

Cited by 54 publications

(36 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the role of local IgE production plays against SEs and mites in the pathogenesis of CRSwNP has been described [7,8,9,10], our findings indicate that fungi are also important allergens that cause eosinophilic inflammation, not only in AFRS but also in CRSwNP. Fungi are environmentally ubiquitous and, except when invasive, are generally not looked upon as being harmful/pathological.…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

Total and Antigen- (Fungi, Mites and Staphylococcal Enterotoxins) Specific IgEs in Nasal Polyps Is Related to Local Eosinophilic Inflammation

Matsuwaki

Uno

Okushi

et al. 2013

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Total and specific immunoglobulin E (IgE) in nasal polyps (NP) is related to local eosinophilic inflammation. However, it remains unclear which antigens cause a stronger accumulation of eosinophils in NP. We investigated whether local IgEs to specific antigens correlated with local eosinophil accumulation. Methods: Total IgE, antigen-specific IgEs [5 species of fungi, staphylococcal enterotoxins A and B (SEA and SEB), cedar pollen, ragweed pollen and house-dust mites] and eosinophil cationic protein (ECP) were measured in sinus mucosa homogenates and serum from 29 patients with chronic rhinosinusitis with NP (CRSwNP), 8 patients with allergic fungal rhinosinusitis (AFRS) and 8 control subjects without CRS. The level of ECP in NP was analyzed for correlations with the total and specific IgE levels in the serum and NP. Results: In CRSwNP, antigen-specific IgEs [Alternaria > mite (Dp) > Aspergillus > SEB > Penicillium > mite (Df), but not the other fungi, SEA or pollens] in the sinus mucosa correlated significantly with the local ECP.In AFRS, antigen-specific IgEs [Penicillium > mite (Df) > Alternaria, but not the other fungi, SEs or pollens] in the sinus mucosa correlated significantly with the local ECP. Conclusions: Local total IgE and antigen (fungi, mites and SEs)-specific IgEs in NP are related to the local eosinophilic inflammation of AFRS and CRSwNP.

show abstract

Section: Discussionmentioning

confidence: 71%

“…AFRS is a representative systemic IgE/IgG-mediated disease, which is a specific allergy for fungi [6]. Local IgE-positive cells in AFRS are increased [9]. Not only antifungal, also antinonfungal IgE, was expressed in sinus tissues of AFRS, compared to the control [10].…”

Section: Introductionmentioning

confidence: 99%

Total and Antigen- (Fungi, Mites and Staphylococcal Enterotoxins) Specific IgEs in Nasal Polyps Is Related to Local Eosinophilic Inflammation

Matsuwaki

Uno

Okushi

et al. 2013

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…There is increasing evidence that local mucosal IgE production is more important in the pathogenesis of fungal sinus inflammation than systemic allergy, which could not be assessed in the current study. [13][14][15] Furthermore, the induced fungal sensitivity in this study is clearly an oversimplification of the immune mechanisms underlying hypersensitivity to fungus, which may be multifactorial, with potential genetic predisposition. These limitations prevent further speculation on the role of fungal allergy in sinonasal fungal biofilm formation with this model.…”

Section: Discussionmentioning

confidence: 96%

A sheep model to investigate the role of fungal biofilms in sinusitis: fungal and bacterial synergy

Boase

Valentine

Singhal

et al. 2011

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…1086 Various studies demonstrate elevation of fungal and nonfungal IgE within AFRS mucosa, and local IgE correlates with sinonasal eosinophilia. 917,1079,1080,1093,1099,1100 Most AFRS patients also have detectable fungal-specific IgE in their mucin. 1077 AFRS is a distinct, often more severe, subclass of CRSwNP.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

559

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

Antigen-specific IgE in Sinus Mucosa of Allergic Fungal Rhinosinusitis Patients

Cited by 54 publications

References 28 publications

Total and Antigen- (Fungi, Mites and Staphylococcal Enterotoxins) Specific IgEs in Nasal Polyps Is Related to Local Eosinophilic Inflammation

Total and Antigen- (Fungi, Mites and Staphylococcal Enterotoxins) Specific IgEs in Nasal Polyps Is Related to Local Eosinophilic Inflammation

A sheep model to investigate the role of fungal biofilms in sinusitis: fungal and bacterial synergy

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Contact Info

Product

Resources

About