Antigen Targeting of Porcine Skin DEC205+ Dendritic Cells

Melgoza-González, Edgar Alonso; Reséndiz-Sandoval, Mónica; Hinojosa-Trujillo, Diana; Hernández-Valenzuela, Sofía; García-Vega, Melissa; Mata-Haro, Verónica; Tepale-Segura, Araceli; Bonifaz, Laura C.; Pérez‐Torres, Armando; Hernández, Jesús

doi:10.3390/vaccines10050684

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Adjuvants are used to enhance and modulate vaccine-induced immunity. Over 60% of identified papers using skin-based vaccination in pigs included adjuvants; the majority mixed or co-inoculated with the vaccine [ 51 , 76 , 88 , 108 , 110 , 112 , 113 , 115 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 129 , 131 , 132 , 133 , 134 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 146 , 151 , 153 , 154 , 156 , 158 , 159 , 160 , 161 , 168 , 179 , 180 , 182 , 186 , 187 , 188 , 196 , 198 , 199 , 201 , 202 ,…”

Section: Resultsmentioning

confidence: 99%

Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs

2023

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The advantages of skin-based vaccination include induction of strong immunity, dose-sparing, and ease of administration. Several technologies for skin-based immunisation in humans are being developed to maximise these key advantages. This route is more conventionally used in veterinary medicine. Skin-based vaccination of pigs is of high relevance due to their anatomical, physiological, and immunological similarities to humans, as well as being a source of zoonotic diseases and their livestock value. We conducted a systematic mapping review, focusing on vaccine-induced immunity and safety after the skin immunisation of pigs. Veterinary vaccines, specifically anti-viral vaccines, predominated in the literature. The safe and potent skin administration to pigs of adjuvanted vaccines, particularly emulsions, are frequently documented. Multiple methods of skin immunisation exist; however, there is a lack of consistent terminology and accurate descriptions of the route and device. Antibody responses, compared to other immune correlates, are most frequently reported. There is a lack of research on the underlying mechanisms of action and breadth of responses. Nevertheless, encouraging results, both in safety and immunogenicity, were observed after skin vaccination that were often comparable to or superior the intramuscular route. Further research in this area will underlie the development of enhanced skin vaccine strategies for pigs, other animals and humans.

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Section: Resultsmentioning

confidence: 99%

Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs

2023

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Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Tang,

Liu,

Zhang

et al. 2024

Advanced Drug Delivery Reviews

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Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine

2023

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Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direct influence on the elicited response that will ensue after antigen uptake. Different approaches using antibodies, natural or synthetic ligands, fused proteins, and DNA vaccines have been explored in various veterinary species, with pigs, cattle, sheep, and poultry as the most frequent models. Antigen-presenting cells can be targeted using a generic approach, such as broadly expressed receptors such as MHC-II, CD80/86, CD40, CD83, etc., or focused on specific cell populations such as dendritic cells or macrophages (Langerin, DC-SIGN, XCR1, DC peptides, sialoadhesin, mannose receptors, etc.) with contrasting results. Interestingly, DC peptides show high specificity to DCs, boosting activation, stimulating cellular and humoral responses, and a higher rate of clinical protection. Likewise, MHC-II targeting shows consistent results in enhancing both immune responses; an example of this strategy of targeting is the approved vaccine against the bovine viral diarrhea virus in South America. This significant milestone opens the door to continuing efforts toward antigen-targeting vaccines to benefit animal health. This review discusses the recent advances in antigen targeting to antigen-presenting cells in veterinary medicine, with a special interest in pigs, sheep, cattle, poultry, and dogs.

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Antigen Targeting of Porcine Skin DEC205+ Dendritic Cells

Cited by 3 publications

References 35 publications

Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs

Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs

Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine

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