Antigenic and genetic characterization of rabies virus isolates from Uruguay

Guarino, H.; Castilho, Juliana Galera; Souto, Juanita; Oliveira, Rafael de Novaes; Carrieri, Maria Luíza; Kotait, Ivanete

doi:10.1016/j.virusres.2012.12.013

Cited by 23 publications

(24 citation statements)

References 22 publications

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“…has already been well documented (Albas et al, 2011;Guarino et al, 2013;Kobayashi et al, 2007Kobayashi et al, , 2005Menozzi, Oliveira, Paiz, Richini-Pereira, & Langoni, 2017;Oliveira et al, 2010). Crossing of the interspecific bat-marmoset barrier has been reported previously and in this report.…”

Section: Spillover Of Different Several Rabv Lineages Between Bat Spesupporting

confidence: 82%

“…Although interspecific contacts of this type (marmosets and bats) have not been reported to date in the natural environment, this type of interaction must have occurred at some point in the past. Spillover of different several RABV lineages between bat species has already been well documented (Albas et al, ; Guarino et al, ; Kobayashi et al, ; Menozzi, Oliveira, Paiz, Richini‐Pereira, & Langoni, ; Oliveira et al, ). Crossing of the interspecific bat–marmoset barrier has been reported previously and in this report.…”

Section: Discussionmentioning

confidence: 89%

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Non‐human primates as a reservoir for rabies virus in Brazil

Kotait

Oliveira²,

Carrieri

et al. 2018

Zoonoses and Public Health

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Rabies virus (RABV) does not persist in the environment as it is a very fragile agent. The primary hosts are mammalian species in the orders Carnivora and Chiroptera. Since the late 1980s, RABV has been isolated from non‐human primates, Callithrix jacchus (the white‐tufted marmoset), in four coastal states (Rio Grande do Norte, Ceará, Piauí and Pernambuco) in north‐eastern Brazil, where this species is indigenous. The original habitat of C. jacchus consisted of two Brazilian biomes, the Atlantic Forest and the Caatinga. However, these marmosets have since adapted to other ecosystems as a result of human activities. Between 1988 and 1989, RABV isolates were obtained from white‐tufted marmosets in the state of Rio Grande do Norte, but antigenic and genetic identification studies were not conducted at that time. In the following years, three additional states reported cases (Ceará, Piauí and Pernambuco). In two of these states (Ceará and Piauí), human cases of rabies transmitted by marmosets were reported. According to Brazilian Health Ministry data, at least 19 human cases in which this species was the source of infection were registered in between 1990 and 2016. Recent findings in laboratory tests of 12 rabid samples from humans and marmosets and the regional transmission among these animals for over 20 years, together with the gradual increase in the affected geographic area, support the concept of the emergence of a new RABV reservoir. Regional tourism, the wild animal trade and the cultural practice of maintaining these animals as pets, particularly in coastal regions, appear to be major risk factors for the increase in human cases. Additional epidemiological and ecological studies are required to better understand local disease dynamics and to identify ideal opportunities for prevention and control of this fatal infection.

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Section: Spillover Of Different Several Rabv Lineages Between Bat Spesupporting

confidence: 82%

Section: Discussionmentioning

confidence: 89%

Non‐human primates as a reservoir for rabies virus in Brazil

Kotait

Oliveira²,

Carrieri

et al. 2018

Zoonoses and Public Health

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“…In northern Uruguay, there have been recent outbreaks of rabies in cattle in locations proximate to the border with RGS (Guarino et al, 2013). Although neighboring bat populations in RGS are the most likely source, other populations farther north could also be potentially contributing migrants to Uruguay based on the widespread distribution of the D2 haplotype.…”

Section: Palabras Clave: Murciélago Vampiro Rabia Filogeografíamentioning

confidence: 99%

“…Although neighboring bat populations in RGS are the most likely source, other populations farther north could also be potentially contributing migrants to Uruguay based on the widespread distribution of the D2 haplotype. In this respect, it is interesting to consider that genetic studies of the rabies virus in the region have shown that the strains from Uruguay (from the 2007 outbreak, Guarino et al, 2013) were related to strains from the mountainous area of São Paulo and Minas Gerais States (lineages R2/R3, see Itou et al, 2016). Therefore, further sampling of vampire bat populations and nuclear markers are needed to ascertain if local populations in Uruguay consist of unique or multiple lineages originated from multiple populations in RGS.…”

Section: Palabras Clave: Murciélago Vampiro Rabia Filogeografíamentioning

confidence: 99%

GENETIC RELATEDNESS OF Desmodus rotundus FROM NORTHERN URUGUAY WITH POPULATIONS FROM THE REMAINDER OF ITS DISTRIBUTION RANGE

2018

BolSZU

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“…Después de 25 años, sin relatos de casos de rabia en Uruguay, Guarino et al (2013) documentaron una epizootia de rabia en herbívoros identificando las variantes AgV3, de D. rotundus, como causante del brote, además de dos variantes adicionales: AgV4 y otra no tipificada, procedente de murciélago no hematófago.…”

Section: Caracterización Genética De Aislamientos Del Rabv En Otros Punclassified

Rabia Transmitida Por Murciélagos en Brasil

Fahl¹,

Garcia²,

Achkar³

et al. 2015

Acta Biol. Colomb.

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RESUMENFrente al desafío que la rabia representa para la industria pecuaria y la salud pública en América Latina, el presente artículo tiene como objetivo hacer una revisión de literatura amplia y crítica sobre la epidemiología de la rabia transmitida por murciélagos en Brasil. El tema es abordado inicialmente desde una perspectiva histórica hasta la caracterización molecular de aislamientos del virus, para finalmente contrastar con la situación de otros países de las Américas. La información referente a Brasil es presentada de manera separada debido a la gran abundancia de especies de murciélagos de diversos hábitos alimenticios, implicadas en la transmisión del virus de la rabia y las complejas relaciones entre los ciclos epidemiológicos revelados por estudios de tipificación antigénica y análisis filogenético, lo cual ha permitido reconocer con más nitidez, la importancia de los quirópteros como reservorios y transmisores de esta enfermedad. Este nuevo escenario epidemiológico exige reexaminar las medidas de control aplicadas hasta el momento, desde un abordaje multidisciplinar, así como cooperación intersectorial y participación por parte de la comunidad.Palabras clave: epidemiología, murciélagos, rabia. ABSTRACTConsidering that rabies represents a challenge for the livestock industry and public health in Latin America, this article is intended to do a comprehensive and critical literature review on the epidemiology of rabies transmitted by bats in Brazil. The subject is addressed from a historical perspective to molecular characterization of rabies virus isolates and finally making a contrast with other countries of the Americas. Information concerning Brazil is presented separately because of the abundance of bats species with different feeding habits, involved in the transmission of rabies virus and the complex relationships between epidemiological cycles in this country, which have been disclosed by antigenic typing and phylogenetic analysis. This has allowed to recognize more clearly the importance of bats as reservoirs and transmitters of this disease. This new epidemiological scenario requires reappraising current control measures, using a multidisciplinary approach, intersectoral cooperation and community participation.

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Antigenic and genetic characterization of rabies virus isolates from Uruguay

Cited by 23 publications

References 22 publications

Non‐human primates as a reservoir for rabies virus in Brazil

Non‐human primates as a reservoir for rabies virus in Brazil

GENETIC RELATEDNESS OF Desmodus rotundus FROM NORTHERN URUGUAY WITH POPULATIONS FROM THE REMAINDER OF ITS DISTRIBUTION RANGE

Rabia Transmitida Por Murciélagos en Brasil

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