1990
DOI: 10.1016/0168-1702(90)90006-w
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Antigenic cross-reaction between a varicella-zoster virus nucleocapsid protein encoded by gene 40 and a herpes simplex virus nucleocapsid protein

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Cited by 11 publications
(8 citation statements)
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“…Instead, their demonstration that a large proportion of seronegative donors could mount a strong pp65-specific CD4 + (and to a lesser extent CD8 + ) response upon in vitro stimulation, led the authors to suggest that these individuals were previously exposed to CMV but failed to mount a humoral immune response [63]. We cannot exclude at this point this possibility nor that TCR cross-reactivity with closely related herpes viruses [66, 67] or with environmental antigens [68, 69] is responsible for the detection of CMV-reactive cells in CMV-seronegative hemodialysis patients. On the other hand, we can reasonably exclude the possibility that signals detected by IFN-γ ELISpot following 19 h of antigen stimulation originate from CMV-specific naïve T cells present in the PBMC population [7072].…”
Section: Discussionmentioning
confidence: 99%
“…Instead, their demonstration that a large proportion of seronegative donors could mount a strong pp65-specific CD4 + (and to a lesser extent CD8 + ) response upon in vitro stimulation, led the authors to suggest that these individuals were previously exposed to CMV but failed to mount a humoral immune response [63]. We cannot exclude at this point this possibility nor that TCR cross-reactivity with closely related herpes viruses [66, 67] or with environmental antigens [68, 69] is responsible for the detection of CMV-reactive cells in CMV-seronegative hemodialysis patients. On the other hand, we can reasonably exclude the possibility that signals detected by IFN-γ ELISpot following 19 h of antigen stimulation originate from CMV-specific naïve T cells present in the PBMC population [7072].…”
Section: Discussionmentioning
confidence: 99%
“…It has been shown that sera from humans infected with HSV-1 or VZV are reactive with each MCP. However, the antibody titers are variable and much lower than those of antibodies to envelope glycoproteins [7,27]. Antibodies specific to MCPs are barely detected in HCMVor EBV-infected human serum or PRV-infected pig serum [10,30].…”
Section: Discussionmentioning
confidence: 97%
“…Of these, MCP is the structural subunit of the hexons and pentons, and is the principal structural element making up the matrix of the icosahedral capsid [16]. In addition, in some herpesviruses such as HSV-1 and varicella-zoster virus (VZV), MCPs serve as an antigen for the humoral immune response during the course of infection, being highly reactive with human antisera as well as being responsible for cell-mediated immunity [7,20,27].…”
mentioning
confidence: 99%
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“…In the case of VZV-seronegative subject P21, it is possible that reconstitution of the VZV-specific T cell repertoire was caused by recently acquired or occult VZV infection or resulted from discordant serologic and cellmediated immune responses (71)(72)(73). Another possibility is that the observed responses are due to antigenic cross-reactivity with another herpes virus (74)(75)(76)(77). Alternatively, three of these four subjects were younger than 2 y of age, again suggesting that thymopoiesis might have played an important part in the spontaneous reconstitution of the VZV-specific T cell compartment.…”
Section: Discussionmentioning
confidence: 99%