Antigenic Similarities within Circulating Immune Complexes in Patients Suffering from Cutaneous Vasculitis

Dambuyant, C.; Thivolet, J

doi:10.1159/000250313

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The pathophysiology is likely to be related to circulating immune complex deposition and such complexes have been detected in serum of affected human patients. 28 A triggering antigen, either endogenous or exogenous, becomes inappropriately immunogenic, for reasons that are unknown. This results in formation of antibodies, which subsequently complex with antigen in the circulation.…”

Section: Clinicalmentioning

confidence: 99%

Acute febrile neutrophilic vasculitis of the skin of young Shar‐Pei dogs

Malík¹,

Foster²,

Martin

et al. 2002

Aust Veterinary J

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Three young Shar-Pei dogs were presented for signs of an acute widespread dermatopathy associated with fever and malaise. Cutaneous lesions initially consisted of multifocal areas of skin discolouration (haemorrhagic papules, macules or plaques) or oedema, preferentially affecting the head and limbs. In some locations, pus-filled bullae were evident also. Cutaneous lesions exuded seropurulent liquid and, in time, usually progressed to full thickness necrosis and ulceration. Lesions were so widespread and severe that one of the dogs was euthanased because its owners could not afford the reconstructive surgery required to close the skin deficits left at the completion of otherwise successful therapy. Histological examination of representative biopsies showed neutrophilic dermatitis and vasculitis, which ultimately resulted in ischaemic necrosis of skin. Therapy with immunosuppressive doses of corticosteroids, and in one case cyclophosphamide, resulted in prompt amelioration of the underlying inflammatory process, although regions of skin deprived of their blood supply eventually became necrotic and sloughed. Healing occurred through granulation, contraction and epithelialisation. The physical findings in these three dogs were so similar that it is likely all suffered from the same breed-related syndrome, an immune-mediated vasculitis precipitated by some event, such as vaccination or an undetected infection. Whatever the inciting cause, it was most likely a one-off event, as the two surviving dogs were readily weaned off immunosuppressive medication without relapse.

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Section: Clinicalmentioning

confidence: 99%

Acute febrile neutrophilic vasculitis of the skin of young Shar‐Pei dogs

Malík¹,

Foster²,

Martin

et al. 2002

Aust Veterinary J

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“…For instance, there is no correlation between the serum immune complex and the biochemical nature of the tissue deposits [23,24]. Furthermore, evidence for precipitation of complement compo nents of the classical pathway sequence (Cl and C4) is not yet well estab lished [25,26]. Although this kind of nonnecrotic reaction to the drug appears to be rare, whenever unexplained fever and chills develop in a patient receiving coumadin it may be followed by skin eruption and the drug should be withdrawn in order to evaluate its possible causative role.…”

Section: Commentmentioning

confidence: 99%

Dermal Vasculitis due to Coumadin Hypersensitivity

et al. 1982

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A 65-year-old patient developed nonpruritic purpuric skin eruptions following 10 days of coumadin treatment. Skin biopsy revealed vasculitis and immunofluorescent studies demonstrated the presence of IgM and C3 deposits in the walls of the affected blood vessels. Rechallenge with coumadin was followed by reappearance of the skin eruptions. Indirect mast cell degranulation test and migration inhibiting factor test were positive in the presence of coumadin. These findings strongly suggest that the skin lesions were induced by an immunologic reaction to warfarin.

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