Antigenic Specificity of Inclusion Bodies in Epidemic Keratoconjunctivitis

Corneal Infiltrates in Epidemic Keratoconjunctivitis

“…Although vision was about 20/25 to 20/30 in these cases, they still com¬ plained of glare at night especially from the headlights of oncoming automobiles. It was felt advisable again to treat these patients, also in a double-blind fashion to determine if topically applied corticosteroid would have any effect on subepithelial corneal infiltrates present for up to one year in the corneas of patients known to have had adenovirus type 8 The criteria for evaluation of drug efficacy differed in these cases as the infiltrates were already present when the drug therapy was begun. Therefore, the following sliding evalua¬ tion scale was established, with 0 to +3 changes in the appearance of infiltrates recorded.…”

Adenovirus keratoconjunctivitis.

“…The eye infection is characterised by a moderate to severe KC, causing in a proportion of the patients hazy vision lasting several years. In the United Kingdom the eye infection is a major economic problem and is probably responsible for the loss of tens of thousands of working days each year. Epidemic keratoconjunctivitis (EKC) caused by adeno 8 is a well described entity (Bietti and Bruna, 1957;Jawetz et al, 1957;Leopold, 1957;Thygeson, 1957;Davidson, 1964;Imre et al, 1964;Liabson et al, 1968;Grist et al, 1970;Dawson et al, 1972;Hart et al, 1972). Severe outbreaks of EKC are especially common in hospitals and factories (Leopold, 1957;Thygeson, 1957;Davidson, 1964;Liabson et al, 1968).…”

“…Fluorescent antibody (FA) staining of conjunctival smears provides a rapid and sensitive method for the detection of adenovirus in conjunctival cells (Imre et al, 1964;Schwartz et al, 1976). Cultural tests for isolation of adenovirus are rather slow and may require between 1 and 8 weeks for detection and identification of the virus.…”