Antigenicity assessment of the Theileria equi merozoite antigen (EMA-2) expressed in Pichia pastoris in mice and horses

Passive immunity in foals born from mares vaccinated against Theileira equi and Streptococcus equi subspecies equi

“…However, at 30 days post parturition (which is about 65 days after the first vaccination), no statistical difference between vaccinated and control groups was found. These results corroborate with those described by VIANNA et al (2019), which demonstrated maintenance of anti-rEMA-2 vaccine antibodies until approximately 60 days after the first vaccination in adult horses. Mares vaccinated with the S. equi antigen showed statistically higher total specific IgG levels than those from the control group even at 30 days postpartum.…”

“…This observation corroborates with those found by KUMAR et al (2008), where they reported that total specific IgG levels did not differ statistically from control values in foals at the age of two months. Further, a study performed by our group (VIANNA et al, 2019), suggests the administration of a third dose around 60 days after the first vaccination in horses using rEMA-2. Specific IgG ELISA results demonstrated that foals born from mares vaccinated against S. equi had an increase of 34.3 times de initial optical density after colostrum absorption, whereas foals born from control mares had an increase of only 5.9 times the initial optical density.…”