1975
DOI: 10.2337/diab.24.7.625
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Antigenicity of “Monocomponent” Pork Insulin in Diabetic Subjects

Abstract: "Single-peak," "single-component," and "monocomponent" insulins have been produced in an attempt to eliminate insulin antigenicity. Recently "single-peak insulin" has been shown to be antigenic. From animal experiments and preliminary human studies it has been claimed that monocomponent (MC) insulin is nonantigenic or only negligibly so. In this study the antigenicity of MC insulin was determined in two groups of diabetic patients. In group 1, seven patients treated with insulin for the first time were given M… Show more

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Cited by 27 publications
(9 citation statements)
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“…These findings support the view that highly purified porcine insulin is of low immunogenicity [16,17,18]. In contrast, Yue and Turtle [19] found clear evidence for the immunogenicity of highly purified porcine insulin when used either de novo or on insulin changeover.…”
Section: Discussionsupporting
confidence: 71%
“…These findings support the view that highly purified porcine insulin is of low immunogenicity [16,17,18]. In contrast, Yue and Turtle [19] found clear evidence for the immunogenicity of highly purified porcine insulin when used either de novo or on insulin changeover.…”
Section: Discussionsupporting
confidence: 71%
“…Over the last 10 years highly purified insu lins have been available and attention has been focussed on their reduced antigenicity [28], Of particular clinical interest has been the possible interrelationship between circu lating insulin antibodies on the one hand and insulin dose, balance of diabetes and devel opment of diabetic microangiopathy, on the other hand [10,26]. Therefore, the new highly purified porcine insulins have become the insulins of choice in many countries in the long-term treatment of newly diagnosed diabetic children.…”
Section: Discussionmentioning
confidence: 99%
“…Thus immunisation of rabbits with a-and b-component is known to produce specific antibodies against these components, in addition to insulin antibodies [3]. Residual amounts of impurities may account for the occurrence of specific proinsulin and insulin antibodies during treatment with Single Peak (SP) (chromatographed) insulin [4] and, to a lesser and generally transient extent, with the monocomponent (MC) (twice chromatographed) insulin preparations used hitherto [5,6,7,8,9].…”
mentioning
confidence: 99%