Antígeno prostático-específico, citoquinas pro-inflamatorias y patología prostática (Hiperplasia benigna y Cáncer): Relación con la malignidad

Alcaide, José Ramón Cansino; Martín, Raúl Vera San; Codes, Fermín Rodríguez de Bethencourt; Bouraoui, Yosra; Berriguete, Gonzalo Rodríguez; Oueslati, Ridha; Pérez-Utrilla, M.; Barthel, Jesús Javier de la Peña; Gómez-Álvarez, Ricardo Paniagua; García, Mar Royuela

doi:10.4321/s0004-06142009000500005

Cited by 7 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An association has been shown to exist between the cytokines IL-4 and TNF-α and circulating levels of KLK3 [56,57]. KLK3 can also induce proliferation and expression of cytokines from peripheral blood lymphocytes [58,59]. High levels of KLK3 can induce expression of IL-6 and TNF-α and activate an immune response involving both IL-4 and IL-5 in ASD patients [60].…”

Section: Discussionmentioning

confidence: 99%

Newborn Screening for Autism: in Search of Candidate Biomarkers

Mizejewski

Lindau-Shepard

Pass³

2013

Biomarkers Med.

View full text Add to dashboard Cite

Background Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3–5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment. Aim This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay. Materials & methods The present study utilized stored frozen specimens from ASD children already diagnosed at 15–36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis. Results Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD. Conclusion This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Newborn Screening for Autism: in Search of Candidate Biomarkers

Mizejewski

Lindau-Shepard

Pass³

2013

Biomarkers Med.

View full text Add to dashboard Cite

show abstract

“…The relationship between the concentrations of SCFAs isolated from patients’ faeces and the tissue expression of pro-inflammatory interleukins (IL-6 and IL-18) was not analysed either. The studies conducted so far, where the expression of IL-6 was confirmed in the immunohistochemical reaction, mainly concerned the differences between BPH and prostate cancer [ 33 ]. These studies have shown that in the case of benign prostatic hyperplasia, high tissue IL-6 expression depends on a high concentration of secreted PSA [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…The studies conducted so far, where the expression of IL-6 was confirmed in the immunohistochemical reaction, mainly concerned the differences between BPH and prostate cancer [ 33 ]. These studies have shown that in the case of benign prostatic hyperplasia, high tissue IL-6 expression depends on a high concentration of secreted PSA [ 33 ]. The studies comparing the factors proving the presence of inflammation analysed, among others, IL-6 concentration [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Tissue immunoexpression of IL-6 and IL-18 in aging men with BPH and MetS and their relationship with lipid parameters and gut microbiota - derived short chain fatty acids

Ratajczak,

Laszczyńska,

Rył

et al. 2023

Aging

View full text Add to dashboard Cite

Recent studies indicate that inflammation is one of the causes of the development of benign prostatic hyperplasia (BPH). Inflammation may result from past infections, metabolic disorders, but also from the state of functioning of the intestinal microbiota. The aim of the study was to assess whether the diagnostic lipid parameters for metabolic syndrome and short-chain fatty acids (SCFAs) are related to the immunoexpression of interleukins in prostate tissue with benign hyperplasia. The study involved 103 men with BPH, who were divided into two groups depending on the presence of MetS. We analysed tissue immunoexpression of two proinflammatory interleukins: IL-6, which is known to be involved in the development of BPH, and IL-18, which has not been analysed so far. The results of our study indicate that men with BPH + MetS in the stroma of the prostate have a significantly higher overall percentage of IL-6+ cells compared to men without MetS ( p = 0.034). The analysis of IL-18 immunoexpression in prostate tissue indicated that in men with BPH + MetS, the glandular part of the prostate had a significantly higher percentage of cells with strong IL-18 expression ( p = 0.040). We also noticed a relationship between tissue expression of IL-6 and IL-18 and lipid parameters (TG and HDL). We conclude that lipid disorders occurring in men with BPH increase inflammation in the prostate gland. Moreover, it has also been demonstrated for the first time that, indirectly, through SCFAs, the gut microbiota can act to prevent or create an inflammatory microenvironment in the prostate gland.

show abstract

Accumulation of Palmitoylcarnitine and Its Effect on Pro‐Inflammatory Pathways and Calcium Influx in Prostate Cancer

Al-Bakheit¹,

Τράκα

Saha

et al. 2016

The Prostate

View full text Add to dashboard Cite

BACKGROUNDAcylcarnitines are intermediates of fatty acid oxidation and accumulate as a consequence of the metabolic dysfunction resulting from the insufficient integration between β‐oxidation and the tricarboxylic acid (TCA) cycle. The aim of this study was to investigate whether acylcarnitines accumulate in prostate cancer tissue, and whether their biological actions could be similar to those of dihydrotestosterone (DHT), a structurally related compound associated with cancer development.METHODSLevels of palmitoylcarnitine (palcar), a C16:00 acylcarnitine, were measured in prostate tissue using LC‐MS/MS. The effect of palcar on inflammatory cytokines and calcium (Ca2+) influx was investigated in in vitro models of prostate cancer.RESULTSWe observed a significantly higher level of palcar in prostate cancerous tissue compared to benign tissue. High levels of palcar have been associated with increased gene expression and secretion of the pro‐inflammatory cytokine IL‐6 in cancerous PC3 cells, compared to normal PNT1A cells. Furthermore, we found that high levels of palcar induced a rapid Ca2+ influx in PC3 cells, but not in DU145, BPH‐1, or PNT1A cells. This pattern of Ca2+ influx was also observed in response to DHT. Through the use of whole genome arrays we demonstrated that PNT1A cells exposed to palcar or DHT have a similar biological response.CONCLUSIONSThis study suggests that palcar might act as a potential mediator for prostate cancer progression through its effect on (i) pro‐inflammatory pathways, (ii) Ca2+ influx, and (iii) DHT‐like effects. Further studies need to be undertaken to explore whether this class of compounds has different biological functions at physiological and pathological levels. Prostate 76:1326–1337, 2016. © 2016 The Authors. The Prostate published by Wiley Periodicals, Inc.

show abstract

Antígeno prostático-específico, citoquinas pro-inflamatorias y patología prostática (Hiperplasia benigna y Cáncer): Relación con la malignidad

Abstract: Summary.-OBJECTIVES: Cancer is a complex process in which cytokines play an important role. Cytokines are low-molecular weight soluble proteins involved in cellular transmission signals and several disorders. Pro-inflammatory cytokines

Cited by 7 publications

References 31 publications

Newborn Screening for Autism: in Search of Candidate Biomarkers

Newborn Screening for Autism: in Search of Candidate Biomarkers

Tissue immunoexpression of IL-6 and IL-18 in aging men with BPH and MetS and their relationship with lipid parameters and gut microbiota - derived short chain fatty acids

Accumulation of Palmitoylcarnitine and Its Effect on Pro‐Inflammatory Pathways and Calcium Influx in Prostate Cancer

Contact Info

Product

Resources

About