Antigenotoxic and antimutagenic effects of Myrciaria dubia juice in mice submitted to ethanol 28-day treatment

Silva, Francisco Carlos da; Picada, Jaqueline Nascimento; Romão, Natália Faria; Sobral, Fabiana de Oliveira Solla; Lemos, Daniela Lucas da Silva; Schons, Sandro de Vargas; Mello, Taciane Letícia de; Silva, Waldiene Melo; Oliveira, Rafaela da Silva; Lucas, Cláudia Perboni; Pereira, Patrı́cia; Chaves, Vítor Clasen; Reginatto, Flávio Henrique; Ferraz, Alexandre de Barros Falcão

doi:10.1080/15287394.2019.1671279

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…O etanol promove danos ao DNA devido ao acetaldeído, um dos metabólitos da substância alcoólica que estimula danos oxidativos, ligações cruzadas e outros erros, o que consequentemente torna o etanol uma substância com alto grau de genotoxicidade, podendo proporcionar mutagênese e carcinogênese. O camu-camu possui ação antígenotóxicas e antimutagênicas promovendo proteção ao DNA de mutações induzidas pelo excesso de etanol, podendo estar associada aos componentes fitoquímicos antioxidantes como por exemplo o ácido ascórbico e antocianinas (Silva et al, 2019).…”

Section: Camu-camu -Propriedade Antitumoralunclassified

Ação de compostos bioativos do camu-camu (Myrciaria dubia) em células tumorais

Quadros,

Chagas,

Nogueira-de-Almeida

et al. 2023

Cuad. Ed. Desar.

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O fruto de origem amazônica camu-camu (Myrciaria dubia) é rico em compostos fenólicos e outros bioativos que contribuem para a saúde de seres humanos. O camu-camu, apesar de ainda pouco explorado no tratamento de doenças, apresenta grande potencialidade de utilização na prevenção e combate a diversas condições crônico-degenerativas, como obesidade, dislipidemia, diabetes e, inclusive, diferentes tipos de cânceres. Alguns trabalhos com análises químicas e bioquímicas e outros estudos in vitro com a Myrciaria dubia têm apontado atividade citotóxica contra neoplasias malignas de diversas linhagens, bem como ações de proteção e reparação de dano de DNA celular. Substâncias encontradas em quantidades significativas no fruto, tais como quercetina, cianidina-3-glicose, resveratrol, ácido ferúlico e epicatequina podem estar envolvidas nesses benefícios. Essa revisão tem como objetivo fazer uma exposição das ações citotóxica e reparadora de DNA do extrato de camu-camu relatados na literatura com diferentes células tumorais.

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Section: Camu-camu -Propriedade Antitumoralunclassified

Ação de compostos bioativos do camu-camu (Myrciaria dubia) em células tumorais

Quadros,

Chagas,

Nogueira-de-Almeida

et al. 2023

Cuad. Ed. Desar.

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“…It was observed that the extract reduced up to 37 % of the chromosomal breaks, suggesting its antimutagenic potential [15] . These antimutagenic and antigenotoxic effects observed in the species may be related to the presence of compounds such as phenols and anthocyanins, which stimulate DNA repair pathways and have an antioxidant nature [14,16] …”

Section: Introductionmentioning

confidence: 98%

“…The seeds of M. dubia are rich in phenolic compounds such as rosmarinic acid, ellagic acid, quercetin, trans‐ resveratrol, [15] gallic acid, cyanidin‐3‐ O ‐glucoside, malvidin‐3,5‐diglucoside, [25] chlorogenic acid, p‐ coumaric acid, ferulic acid, rutin, [26] syringic acid and caffeic acid [27] . Thus, in samples of its fruits, several compounds such as quercetin, myricetin, ellagic acid, caffeic acid, gallic acid, ferulic acid, p‐ coumaric acid, [21] ascorbic and dehydroascorbic acid [24] and anthocyanins such as cyanidin‐3‐ O ‐glucoside and delphinidin‐3‐ O ‐glucoside [16] have already been identified. Extracts from the fruits of Myrciaria vexator have flavonoids, tannins, and ascorbic acid in their composition, in addition to an important content of iron, calcium, and phosphorus [45] ( Figure 2).…”

Section: Introductionmentioning

confidence: 99%

Myrciaria Genus: Bioactive Compounds and Biological Activities

Pereira

Charret

Machado

et al. 2022

Chemistry & Biodiversity

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The Myrtaceae family is of angiosperms, imposing its size and economic, cultural, and scientific importance. The genus Myrciaria, belonging to this family, has 33 species currently accepted, many of which are research targets aimed at elucidating their bioactive compounds and biological activities. Most species of the Myrciaria genus have terpenes in their composition, mainly mono and sesquiterpenes, and phenolic compounds such as tannins, phenolic acids, and flavonoids. Other secondary metabolites are also observed, such as alkaloids, steroids, coumarins, saponins, and naphthoquinones. These bioactive compounds are closely related to these species′ most diverse biological activities: antioxidant, anti‐inflammatory, analgesic, antiproliferative, antimicrobial, antiparasitic, insecticide, metabolic, protective, and nutraceutical. This work aims to provide a review of secondary metabolites and medicinal properties related to the genus Myrciaria, thus stimulating further studies on the species of this genus.

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“…13,14 A recent work links the presence of ascorbic acid and anthocyanins to the antigenotoxic and antimutagenic effects of M. dubia fruits, which protect DNA against damage induced by ethanol. 15 These features point to a great promise in the research for new medical drugs based on synthetic or natural molecules with antioxidant, antinociceptive, and antiedematogenic effect. 16,17 Based on these evidences, the aim of the present study is to evaluate the antinociceptive and anti-inflammatory potential of M. dubia fruits.…”

Section: Introductionmentioning

confidence: 99%

Myrciaria dubia Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice

Silva

Souza

Bassoli

et al. 2021

Journal of Medicinal Food

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The Myrciaria dubia (Myrtaceae) fruit is traditionally used to treat malnutrition due to its high levels of vitamin C and phenolic compounds. Because of its composition, this plant is very promising in the research of novel natural treatment for pain disorders. This study analyzed the phytochemical profile of M. dubia juice and assessed its antinociceptive and antiedematogenic potential. The phytochemical profile was determined through high-performance liquid chromatography (HPLC), the oral antinociceptive effect of M. dubia 50% juice (Md50) was evaluated by formalin, hot plate and Complete Freund's Adjuvant tests and the antiedematogenic activity by paw edema. HPLC revealed the presence of ascorbic acid, rutin, and ellagic acid as major compounds. Md50 showed an antinociceptive effect in the acute and chronic phases of the formalin test. In the hot plate test, Md50 also induced an antinociceptive effect of 0.5 up to 6 h, showing antinociceptive and antiedematogenic potential without changing the spontaneous locomotion of animals. All protocols were submitted and approved by the Ethics Committee for use of Animals of the Lutheran University of Brazil (protocol No. 2013-30P).

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Antigenotoxic and antimutagenic effects of Myrciaria dubia juice in mice submitted to ethanol 28-day treatment

Cited by 12 publications

References 53 publications

Ação de compostos bioativos do camu-camu (Myrciaria dubia) em células tumorais

Ação de compostos bioativos do camu-camu (Myrciaria dubia) em células tumorais

Myrciaria Genus: Bioactive Compounds and Biological Activities

Myrciaria dubia Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice

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