Antigenotoxicity of artepillin C <i>in vivo</i> evaluated by the micronucleus and comet assays

Neto, Moacir de Azevedo Bentes Monteiro; Lima, Ildercílio Mota de Souza; Furtado, Ricardo Andrade; Bastos, Jairo Kenupp; Filho, Ademar A. Da Silva; Tavares, Denise Crispim

doi:10.1002/jat.1614

Cited by 18 publications

(12 citation statements)

References 39 publications

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“…Positive control compounds in micronucleus tests, other than comet assays, have also been used (de Azevedo Bentes Monteiro Neto et al , 2011; Malini et al , 2010). DXR was selected through being an effective genotoxic and mutagenic agent in in vivo and in vitro studies (Antunes and Takahashi, 1998; Takeuchi et al , 2008; Dutra et al , 2009; Tan and Porter, 2009; Ribeiro et al , 2010).…”

Section: Discussionmentioning

confidence: 99%

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Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice

Almeida¹,

Darin²,

Hernandes³

et al. 2012

Genet. Mol. Biol.

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Copaiba oil-resin, extracted from the trunk of Copaifera, and traditionally used in folk medicine in the treatment of various disorders, has been shown to be an effective antiinflamatory, antitumor, antitetanus, antiseptic and anti-blenorrhagea agent. As, there are few studies evaluating its genotoxicity, this aspect of the commercial oil-resin, and its volatile and resinous fractions, were evaluated in mice by comet assay and micronucleus (MN) test. A single dose of oil resin, volatile or resin fractions (500; 1,000 or 2,000 mg/kg b.w.) was administered by gavage. The chemical compositions of Copaiba oil resin and its fractions was analyzed by gas chromatography. According to comet assaying, treatment with either one did not increase DNA damage, and as to MN testing, there was no alteration in the incidence of micronucleated polychromatic erythrocytes. Chromatographic analysis of the oil-resin itself revealed sesquiterpenes, diterpenic carboxylic acid methyl esters and high levels of β-caryophyllene. Thus, it can be assumed that the oil resin and volatile and resinous fractions from the commercial product are not genotoxic or mutagenic.

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Section: Discussionmentioning

confidence: 99%

“…MMS causes predominantly methylation in nitrogens of purine rings, which can lead to the formation of apurinic sites (de Azevedo Bentes Monteiro Neto et al , 2011). Our results demonstrated that a single administration of MMS (50 mg/kg i.p.)…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice

Almeida¹,

Darin²,

Hernandes³

et al. 2012

Genet. Mol. Biol.

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“…Considering that baccharin is not the only phytochemical present in propolis, the same group of Oliveira (2013) [201] and the scientific group of de Azevedo Bentes Monteiro (2011) [204] explored the protective activity of artepillin C (3, 5-diprenyl p-coumaric acid-), one of the major phenolic compounds found in Brazilian green propolis. De Azevedo Bentes Monteiro Neto and colleagues analyzed the antigenotoxicity of artepillin C against the damage produced by DXR and MMS in male Swiss mice using the micronucleus and comet assays.…”

Section: Natural Resinmentioning

confidence: 99%

Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin

et al. 2018

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Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.

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“…The results showed that artepillin C itself was not genotoxic in the mouse comet extent assays. Artepillin C at the tested doses significantly reduced DNA damage extent in liver cells induced by MMS [62]. León-Mejía et al, evaluated genotoxic effects in a population exposed to coal residues from the open-cast mine "El Cerrejón".…”

Section: Recents Studies Using Comest Assaymentioning

confidence: 99%

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

Gharsalli¹

2016

J Environ Anal Toxicol

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Antigenotoxicity of artepillin C in vivo evaluated by the micronucleus and comet assays

Cited by 18 publications

References 39 publications

Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice

Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice

Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin

Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents

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