Antigens and immune responses in <i>Candida albicans</i> infection

Ashman, R. B.; Papadimitriou, J. M.; Ott, Alewijn; Warmington, John R.

doi:10.1038/icb.1990.1

Cited by 18 publications

(3 citation statements)

References 111 publications

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“…However, the pathogenic differentiating program of C. albicans also depends on the host response. Macrophages are, among others, major effectors involved in the resistance to C. albicans (Ashman et al, 1998, 1990Vazquez-Torres and Balish, 1997. Candida cells can survive inside the macrophage and prevent phagolysosome formation by forming hyphae (Vazquez-Torres and Balish, 1997).…”

Section: Introductionmentioning

confidence: 99%

Candida albicans CTN gene family is induced during macrophage infection: homology, disruption and phenotypic analysis of CTN3 gene

Prigneau

Porta

Maresca

2004

Fungal Genetics and Biology

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Section: Introductionmentioning

confidence: 99%

Candida albicans CTN gene family is induced during macrophage infection: homology, disruption and phenotypic analysis of CTN3 gene

Prigneau

Porta

Maresca

2004

Fungal Genetics and Biology

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“…Ashman y cols (30), desarrollaron una teoría en la que antígenos de la cándida albicans, a través de reacción cruzada, llevarían a la producción de auto-anticuerpos que actuarían secundariamente contra la mucosa vulvovaginal. Por otro lado, el antígeno que se ha aislado es de 48 kDa y muestra una homología con la enzima enolasa (31).…”

Section: Fisiopatologíaunclassified

Vulvodinia: Un Diagnóstico Olvidado Frente Al Dolor Vulvar

2010

Rev. chil. obstet. ginecol.

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RESUMENLa vulvodinia es una patología compleja y de difícil tratamiento. Se define como un dolor crónico de la vulva, que puede ser generalizado o localizado. La primera vez que se escribe sobre esta fue en 1889, por Skene. Sin embargo, es sólo hasta 1976, que los miembros de la International Society for Study of Vulvovaginal Diseases, reconocieron el dolor vulvar como una entidad patológica. Se estima una prevalencia de un 15%, con unas 14 millones de mujeres que lo padecen en EEUU. Generalmente consultan múltiples veces y a diferentes médicos, antes de llegar a un diagnóstico. No existen pruebas específicas, por lo que la clínica y el examen físico son las principales herramientas. Se deben excluir todas aquellas patologías que explican este dolor crónico vulvar. Su etiología es multifactorial, involucrando cambios a nivel de nociceptores, alteraciones de la inervación y la presencia de factores inflamatorios. Sin embargo, no podemos dejar de lado los aspectos psicosexuales, que pueden modular o desencadenar el dolor vulvar, al encontrar un sustrato alterado a nivel de estos tejidos. Basándose en estos aspectos, hoy existen diferentes tratamientos, que son efectivos si los utilizamos asociados y en forma gradual, ya que se potencian entre ellos. PALABRAS CLAVE: Dolor vulvar, vulvodinia, disestesia vulvar, dolor vulvar crónico, vestibulitis vulvar SUMMARYVulvodynia is a complex pathology and difficult to treat. In 1889 Skene was the first who write about this. However, only until 1976 the members of the International Society for Study of Vulvovaginal Diseases, recognized the vulvar pain as a disease entity. Prevalence estimated at 15% with an estimated 14 million women who suffer in the USA. A high number of gynaecologists do not know this diagnosis. For this reason women consult multiple times and to different doctors to reach a diagnosis. There are no specific tests for diagnosis. Finding in the clinical and physical examination are the main tools for this diagnosis. The different pathologies that could explain the presence of a chronic vulvar pain must be excluded. Undoubtedly its aetiology is multifactorial, involving changes in the number of nociceptors and alterations in the innervations, and the presence of inflammatory factors that may be the starting point of this pathology, as it seeks to explain the neuropathic theory. However we can not ignore the psychosomatic theory in explaining the psychosexual disorders as a trigger vulvar pain, in these altered tissues. Based on these aspects there are now treatments that are more or less effective when are gradually associated for better results.

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“…After injury, host immune response to Candida infection is complex and multilayered. Candida invasion generates humoral and cell-mediated immune responses; the relative importance of each has been debated (1). However, it is generally believed that phagocytic cells, particularly PMNL, play a primary role in the control of Candida growth (7).…”

mentioning

confidence: 99%

Elevated Candida antigen titers are associated with neutrophil dysfunction after injury

Sweeney

Rosemurgy

Wei

et al. 1994

Clin Diagn Lab Immunol

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This study was undertaken to determine if impaired neutrophil (polymorphonuclear leukocytes [PMNL]) function is associated with an elevated Candida antigen titer after injury. PMNL from eight severely injured adults with Candida antigen titers of > or = 1:4 (titer positive) were evaluated for the ability to inhibit growth of Candida albicans in vitro by using a [3H]glucose incorporation assay. PMNL from eight severely injured adults with titers of < 1:4 (titer negative) and from eight healthy volunteers were studied for comparison. PMNL from the titer-positive patients had suppressed ability to inhibit C. albicans growth compared with PMNL from titer-negative patients and healthy volunteers. In vitro, PMNL function against C. albicans could be augmented significantly by cytokines. Granulocyte macrophage-colony-stimulating factor was most potent at augmenting function, followed by interleukin-8 and gamma interferon. Injured patients with elevated candida antigen titers have impaired PMNL function against C. albicans, and this function can be restored by cytokines.

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Antigens and immune responses in Candida albicans infection

Cited by 18 publications

References 111 publications

Candida albicans CTN gene family is induced during macrophage infection: homology, disruption and phenotypic analysis of CTN3 gene

Candida albicans CTN gene family is induced during macrophage infection: homology, disruption and phenotypic analysis of CTN3 gene

Vulvodinia: Un Diagnóstico Olvidado Frente Al Dolor Vulvar

Elevated Candida antigen titers are associated with neutrophil dysfunction after injury

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