Antigens of the Thymus (Part 1 of 3)

Schlesinger, M

doi:10.1159/000313173

Cited by 47 publications

(17 citation statements)

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“…It was previously demonstrated that some thymic antigens are found also in other tissues and that thymic components crossreact with other antigens in the body (32). For example, an antigenic correlation has been demonstrated between human brain and thymus (33), and it is possible that this correlation may have some bearing on the cellular response to neural antigens which has been observed in some cases of MG (11,34).…”

Section: Discussionmentioning

confidence: 99%

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

Aharonov¹,

Tarrab‐Hazdai²,

Abramsky³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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A defined immunological cross-reaction was observed between acetylcholine receptor fraction from the electric eel, Electrophorus electricus, and two calf thymus fractions. The cross-reaction was demonstrated on the cellular level by means of the lymphocyte transformation technique, and on the humoral level, by means of the microcomplement fixation assay.In the human disease myasthenia gravis both acetylcholine receptor at the neuromuscular junction and the thymus are affected, probably by an autoimmune mechanism. The immunological cross-reaction between acetylcholine receptor and thymic components may explain the association between endplate and thymus disorders in myasthenia gravis.

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Section: Discussionmentioning

confidence: 99%

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

Aharonov¹,

Tarrab‐Hazdai²,

Abramsky³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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“…A minor population of medium to large sized, rapidly cycling cells are known to generate the bulk of small, nondividing thymocytes [3,7,[13][14][15]. A dif ferent and more recent subdivision is into a minor, medullary, cortisoneresistant population with many peripheral T-cell surface characteristics [low 0 (Thy 1); high H2; TL -ve] and a major, cortical, cortisone-sensi tive population with thymus-unique surface characteristics [high 0 (Thy 1); low H2; TL +ve] [19]. Most immunological activities of mouse thy mus are associated with the minor, low 0 subset.…”

Section: Introductionmentioning

confidence: 99%

“…Originally these were considered to have direct precursor-product relationships and represent 'immature' and 'mature' T cells [2,11], a view that some still hold [29,30]. More recently, Shortman et al [21,22,24,25] and Schlesinger [19,20] have proposed that the two populations represent largely separate lines of development. A combination of cell separation and ki netic studies on thymocyte development in intact mice has provided direct evidence against the precursor-product model, and suggested the two sub populations are either independent streams [25], or branched streams derived from a common dividing precursor [8].…”

Section: Introductionmentioning

confidence: 99%

The Differentiation of T Lymphocytes

Hopper¹,

Rydén²,

Shortman³

1978

Pathobiology

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Dissociated mouse thymocytes were cultured under optimized conditions in Marbrook vessels in order to follow some aspects of T-cell differentiation. Under particular conditions it was possible to obtain a 50% net increase in the total number of the peripheral T-cell like, minor low Θ thymocyte subpopulation over the first day of culture, although this increase was lost with further incubation. The increase arose from proliferation of preexistent low Θ cells, and not from transformation of the major, high Θ population. Under all conditions the high Θ cells died rapidly in culture. These results are in accordance with the view that the high Θ and low Θ thymocytes represent separate streams of T-cell development. There was a striking increase in responsiveness to phytohemagglutinin and con-canavalin A after culture of thymocytes under these conditions. However, this was ascribed, not to the development of new immunocompetent T cells, but to selective cell death in the cultures eliminating some inhibitory elements. No increase in progenitors of cytotoxic lymphocytes was obtained. The results demonstrate some potential artifacts in assessing the immunocompetence of cultured thymocytes.

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“…Besides differing in their antigenic characteristics [20], these two pop ulations of thymocytes, sensitive and resistant to corticosteroids, were shown to markedly differ in their electrophoretic mobility (EPM) [19,26,27], a physical parameter which reflects the net electronegative cell sur face charge [1]. Recently, evidence was furthermore obtained that both of these populations are themselves heterogeneous and composed of several electrophoretically distinct subpopulations which might represent stages in the maturation and differentiation of thymocytes [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Dose-Related Effect of Hydrocortisone Treatment on the Electrokinetic Properties and Mitogen Responsiveness of Mouse Thymocytes

Dumont¹,

Robert²

1976

Int Arch Allergy Immunol

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The electrophoretic mobility (EPM) and the ability to synthesize DNA in vitro either spontaneously or in response to concanavalin A (Con A) and phytohemagglutinin (PHA) were investigated on thymocytes from adult female Swiss/B mice which had received intraperitoneally, 2 days previously, various doses (10–750 mg/kg body weight) of hydrocortisone acetate (OHC). A first group of thymocytes, highly sensitive to OHC, rapidly decreased in proportion following administration of increasing doses of OHC (10–125 mg/kg body weight) and included the totality of low-EPM thymocytes (EPM < 1.0 μm sec^––¹ V^––1 cm) together with about 70% of the high-EPM thymocytes encountered in the normal thymus. The second group of thymocytes (4% of the initial cellularity), which resisted to OHC at 125 mg/ kg body weight and was only reduced by half with doses of OHC 6-fold larger, was composed essentially of high-EPM cells. The mean EPM of both groups tended to increase with increasing doses of OHC which suggests that among these two groups thymocytes are all the more OHC-sensitive as they possess a low surface charge. Spontaneous DNA synthesis, measurable on the first 24 h of in vitro cultivation, markedly dropped after treatment with OHC at doses higher than or equal to 62 mg/kg body weight. This loss of early spontaneous proliferation coincided with the disappearance of medium-EPM thymocytes. By contrast, proliferative response of thymocytes to mitogens was enhanced by OHC pretreatment of donors and roughly paralleled the enrichment in high-EPM cells. However, administration of the largest amounts of OHC diminished this mitogen responsiveness, although PHA reactivity was less affected than Con A reactivity.

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Antigens of the Thymus (Part 1 of 3)

Cited by 47 publications

References 0 publications

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

The Differentiation of T Lymphocytes

Dose-Related Effect of Hydrocortisone Treatment on the Electrokinetic Properties and Mitogen Responsiveness of Mouse Thymocytes

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