Antiglomerular basement membrane antibody mediated disease in the British Isles 1980-4.

Savage, Caroline O. S.; Pusey, Charles D.; Bowman, Christine; Rees, Andrew J.; Lockwood, C. M.

doi:10.1136/bmj.292.6516.301

Cited by 240 publications

(132 citation statements)

References 9 publications

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“…Other recent series tend to show a more even sex distribution 2,19 . In our 1991 study on anti-GBM subclasses we had no patients with predominance of IgG4, but we found that high IgG4 was more common in women 7 .…”

Section: Discussionmentioning

confidence: 99%

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Circulating Anti–Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti–Glomerular Basement Membrane Disease

Ohlsson

Herlitz

Lundberg

et al. 2014

American Journal of Kidney Diseases

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Section: Discussionmentioning

confidence: 99%

“…This finding was, however, not confirmed by Cui et al 8 . Anti-GBM disease has been shown to have a bimodal age distribution, with one peak around 20 and a second peak between 60 and 70 19 . In our study the median age at diagnosis was 60 years, considerably higher than the age of the present cases 2 .…”

Section: Discussionmentioning

confidence: 99%

Circulating Anti–Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti–Glomerular Basement Membrane Disease

Ohlsson

Herlitz

Lundberg

et al. 2014

American Journal of Kidney Diseases

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“…Previous studies indi- cated that the age distribution of patients with GP seems to be bimodal, with one peak among young adults and another peak between 60 and 70, and that a significant proportion of patients with GP also have ANCA (10,12,13,16,17,20,21). This study confirms both of these observations and brings them together; as shown in Figure 1, the bimodality seems to stem from two distinct subgroups, one ANCA negative with a peak incidence age between 20 and 30 and one double-positive group with an incidence peak between 60 and 70.…”

Section: Discussionmentioning

confidence: 99%

Antigen and Epitope Specificity of Anti–Glomerular Basement Membrane Antibodies in Patients with Goodpasture Disease with or without Anti-Neutrophil Cytoplasmic Antibodies

Yang¹,

Hellmark²,

Zhao³

et al. 2007

Journal of the American Society of Nephrology

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Goodpasture disease (GP) is defined by the presence of anti-glomerular basement membrane (anti-GBM) antibodies and rapidly progressive glomerulonephritis. Besides anti-GBM, many patients with GP produce anti-neutrophil cytoplasmic antibodies (ANCA). For elucidation of the pathophysiologic significance of ANCA in this setting, epitope and antigen specificity of the anti-GBM antibodies and antigen specificity of ANCA were studied. Bovine testis ␣(IV)NC1 (tNC1); recombinant human ␣1, ␣3, ␣4, and ␣5(IV)NC1 (r␣1 through r␣5); and three chimeric proteins that contain previously defined epitope regions designated E A , E B , and S2 were used to examine the anti-GBM antibodies by ELISA in 205 Chinese patients with GP with or without ANCA. In the 205 anti-GBM antibody-positive sera, 63 (30.7%) were also ANCA positive (61 myeloperoxidase-ANCA and six proteinase 3-ANCA, four being triple positive). All 205 sera recognized tNC1 and r␣3(IV)NC1. In the double-positive group, 54.0, 66.7, 71.4% of the sera could recognize r␣1, r␣4, and r␣5, respectively, compared with 49.3, 60.6, and 55.6% for patients with anti-GBM antibodies alone. The levels of the antibodies to r␣3, tNC1, and the ␣3/␣1 ratio were lower in the double-positive group than that in patients with anti-GBM antibody alone (P < 0.05). Most of the sera could recognize the epitope regions E A , E B , and S2, but the absorbance values to E A , E B , and S2 were lower in double-positive group (P < 0.05). Double-positive patients had a broader spectrum of anti-GBM antibodies and lower levels of antibodies against ␣3(IV)NC1 compared with that of patients with anti-GBM antibodies alone.

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“…Some of the early series reported a seasonal variation in disease incidence, with peaks in spring and early summer, which in the absence of any reported association with atopy, suggest an infectious trigger (9). It is of historical interest that Ernest Goodpasture's original description of GN associated with alveolar hemorrhage was in the context of the influenza outbreak of 1919, although it is not clear whether his patient had genuine anti-GBM disease (19).…”

mentioning

confidence: 99%

Clustering of Anti-GBM Disease: Clues to an Environmental Trigger?

McAdoo

Pusey

2016

CJASN

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Antiglomerular basement membrane antibody mediated disease in the British Isles 1980-4.

Cited by 240 publications

References 9 publications

Circulating Anti–Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti–Glomerular Basement Membrane Disease

Circulating Anti–Glomerular Basement Membrane Antibodies With Predominance of Subclass IgG4 and False-Negative Immunoassay Test Results in Anti–Glomerular Basement Membrane Disease

Antigen and Epitope Specificity of Anti–Glomerular Basement Membrane Antibodies in Patients with Goodpasture Disease with or without Anti-Neutrophil Cytoplasmic Antibodies

Clustering of Anti-GBM Disease: Clues to an Environmental Trigger?

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