Antiglomerular Basement Membrane Disease in a Pediatric Patient: A Case Report and Review of the Literature

Abstract

Goodpasture's syndrome (GPS) remains a very rare disease entity in the pediatric population characterized by the presence of pulmonary hemorrhage and rapidly evolving glomerulonephritis. We hereby describe the case of a 2-year-old girl who presented with renal failure and was diagnosed with GPS. A brief review of the literature in regard to data on demographics, pathogenesis, clinical features, diagnosis, treatment, and prognosis for renal recovery is also provided.

IgA Nephropathy and Atypical Anti-GBM Disease: A Rare Dual Pathology in a Pediatric Rapidly Progressive Glomerulonephritis

“…Pediatric anti-glomerular basement membrane (anti-GBM) disease is a rare occurrence accounting for 0.5% cases of end-stage renal disease in pediatric population [ 1 ]. Most cases in the pediatric age group tend to occur in teenagers with a male preponderance [ 2 , 3 , 4 , 5 , 6 ] with the youngest patient being 11 months of age [ 7 ]. It results from antibodies directed against NC1 domains of alpha 3 type IV collagen, and in its typical form presents with disruptive GBM necrotizing lesions/crescents in the kidney and pulmonary hemorrhage [ 8 ].…”

Anti-glomerular basement membrane disease in children: can Sars-Cov-2 be a trigger?

“…The etiology is often unknown, but upper and lower tract infections may trigger the disease. Clustering of cases has been observed in influenza A outbreaks in the past 2,5 . Early diagnosis is important in terms of renal function recovering.…”

Doença antimembrana basal glomerular em crianças: o Sars-Cov-2 pode ser um fator desencadeador?

“…As manifestações renais são caracterizadas por lesão renal aguda com urinálise mostrando proteinúria, desencadear a doença. Um agrupamento de casos foi observado em surtos de influenza A no passado 2,5 . O diagnóstico precoce é importante para a recuperação da função renal.…”